Cited by 334Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Fifty years of a command neuron: the neurobiology of escape behavior in the crayfish

Edwards, Donald H., Heitler, William J., Krasne, Franklin B.·1999·Trends in Neurosciences

Abstract

Fifty years ago C.A.G. Wiersma established that the giant axons of the crayfish nerve cord drive tail-flip escape responses. The circuitry that includes these giant neurons has now become one of the best-understood neural circuits in the animal kingdom. Although it controls a specialized behavior of a relatively simple animal, this circuitry has provided insights that are of general neurobiological interest concerning matters as diverse as the identity of the neural substrates involved in making behavioral decisions, the cellular bases of learning, subcellular neuronal computation, voltage-gated electrical synaptic transmission and modification of neuromodulator actions that result from social experience. This work illustrates the value of studying a circuit of moderate, but tractable, complexity and known behavioral function.

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Registry

Crossref · 10.1016/s0166-2236(98)01340-x

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68 of 68 references verified0 citation errors · 0 not checkable

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  • The crayfish escape response is triggered by information entering through arrays of hair cells on its tail and abdomen.

    “This escape response is triggered by information that enters the system through arrays of hair cells located on its tail and abdomen12–14.”

    From Corollary discharge across the animal kingdom (2008) · cites this paper as [12]

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Authors
Edwards, D. H., Heitler, W. J., & Krasne, F. B.
Affiliations
  • Georgia State University (US)
  • University of St Andrews (GB)
  • University of California, Los Angeles (US)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1999-04
Volume
22
Issue
4
Pages
153-161
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2097756276
Cited by
334
References
68
Citations by year
2026: 5 · 2025: 7 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 5 · 2020: 15 · 2019: 14 · 2018: 19 · 2017: 19 · 2016: 5 · 2015: 17 · 2014: 16 · 2013: 7 · 2012: 16
FWCI
1.28
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Biotechnology and Biological Sciences Research Council
  • National Science Foundation
  • U.S. Public Health Service
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
crayfish, giant axons, command neurons, nerve cord, neural circuits, behavioral decision making, learning, neural computation, neuromodulation, social experience
MeSH terms
Abdomen, Afferent Pathways, Animals, Avoidance Learning, Axons, Astacoidea, Efferent Pathways, Escape Reaction, Biological Evolution, Locomotion, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Social Environment, Tail, Ion Channel Gating, Ganglia, Invertebrate

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