Neurobehavioural defects in adult mice neonatally exposed to nicotine: changes in nicotine-induced behaviour and maze learning performance
Abstract
Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (3.3, 33, or 66 microg nicotine-base/kg body wt.) s.c. twice daily on 5 consecutive days to study dose-response effects of nicotine on adult spontaneous and nicotine-induced motor behaviour. The nicotine-induced behaviour test revealed a hypoactive response to nicotine in 4-month-old mice neonatally exposed to 33 or 66 microg nicotine-base, whereas the response to nicotine in control animals and mice exposed to 3.3 microg nicotine-base was an increased activity. Learning and memory functions were also investigated in adult animals neonatally exposed to 66 microg nicotine-base/kg body wt. in the same manner, in the Morris water maze and in the Radial arm maze. In the swim maze and the Radial arm maze tests, no significant differences were observed between nicotine-treated and control animals at the age of 4 months. At 7 months, however, a significant difference in performance was evident, indicating a time-response/time-dependent effect. Furthermore, it was shown that in mice exposed neonatally to a nicotine dose known to inhibit the development of the nicotinic low affinity-binding site (LA), the response to nicotine could not cause any increase in spontaneous motor activity as seen in controls.
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Animal studies of prenatal nicotine exposure and cognitive development are more consistent, suggesting global learning and memory impairments.
“there is greater consistency among animal studies examining the effects of prenatal nicotine exposure on cognitive development, suggestive of global impairments in learning and memory.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [188]
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- Authors
- Ankarberg, E., Fredriksson, A., & Eriksson, P.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Ankarberg, Emma
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 123
- Issue
- 2
- Pages
- 185-192
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2004267080
- Cited by
- 45
- References
- 25
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- spontaneous motor activity, learning and memory, Morris water maze, radial maze, dose-response relationship, time-dependent effects, neurobehavioral deficits, adult mice
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Arousal, Dose-Response Relationship, Drug, Escape Reaction, Male, Mice, Inbred Strains, Motor Activity, Nicotine, Problem Solving, Mental Recall, Receptors, Nicotinic, Maze Learning, Mice
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