Removal of the hippocampus and transection of the fornix produce comparable deficits on delayed non-matching to position by rats
Abstract
Rats with radiofrequency lesions of the fimbria/fornix or with extensive aspiration lesions of the hippocampal region (the hippocampus proper, dentate gyrus, and subicular complex) were tested on their performance of a delayed non-matching to position task which had been learnt before surgery. On a given trial, one of two sample levers was presented in a random manner. Following a response on this lever and a subsequent delay, both levers were presented and reward was now contingent on a response on the lever that was not used as the sample. Both lesions produced equivalent performance deficits on this test of spatial working memory, the pattern of these deficits being consistent with a mnemonic impairment. The lack of difference between these two groups on a variety of performance measures indicates that hippocampal connections passing through the fornix are not only necessary for this test, but that non-fornical hippocampal connections appear unable on their own to maintain accurate responding.
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Fornix and anterior thalamic lesions, as well as hippocampal and medial prefrontal lesions, persistently impair delayed nonmatching-to-position.
“In contrast, both fornix and anterior thalamic lesions, as well as hippocampal and medial prefrontal lesions (Aggleton et al., 1992, 1995), persistently impair this task.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Aggleton et al., 1992
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Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282 · see citing works
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Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
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Self-citationCENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348 · see citing works
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Self-citationBussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.011 · Cited by 299 · see citing works
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- Authors
- Aggleton, J. P., Keith, A. B., Rawlins, J. N. P., Hunt, P. R., & Sahgal, A.
- Affiliations
- Durham University (GB)
- Newcastle upon Tyne Hospital (GB)
- University of Oxford (GB)
- Corresponding author
- Aggleton, J.P.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 52
- Issue
- 1
- Pages
- 61-71
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2018650449
- Cited by
- 161
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, fornix, spatial working memory, radiofrequency lesions, aspiration lesions, dentate gyrus, subiculum, fimbria, rats
- MeSH terms
- Animals, Appetitive Behavior, Association Learning, Brain, Brain Mapping, Discrimination Learning, Hippocampus, Limbic System, Male, Neural Pathways, Orientation, Problem Solving, Rats, Inbred Strains, Reaction Time, Mental Recall, Retention, Psychology, Rats
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