New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats
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We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be used to study reward learning, memory, perceptual discrimination, object-place associative learning, attention, impulsivity, compulsivity, extinction, simple Pavlovian conditioning, and other constructs. The tests can be deployed using a 'flexible battery' approach to establish a cognitive profile for a particular mouse or rat model. We have found these tests to be capable of detecting not just impairments in function, but enhancements as well, which is essential for testing putative cognitive therapies. New tests are being continuously developed, many of which may prove particularly valuable for schizophrenia research.
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Available mouse operant touchscreen paradigms seem to have face validity relative to human cognitive touchscreen tasks, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome.
“available mouse operant touchscreen paradigms seem to have face validity63,89,101–104 relative to human cognitive touchscreen tasks97, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome63.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [103]
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“Touchscreen versions of this task are also available in which the nose poke holes and stimulus lights are replaced with an LCD screen (Romberg et al., 2011; Bussey et al., 2012).”
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
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Synaptic scaffold evolution generated components of vertebrate cognitive complexity
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Self-citationThe touchscreen operant platform for testing working memory and pattern separation in rats and mice.
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“…recent focus on measuring cognitive deficits in rodent models (Jentsch, 2003; Kellendonk et al., 2009; Young et al., 2009; Keeler and Robbins, 2011; Bussey et al., 2012) and the known influence of strain and housing conditions on cognitive measures (Chapillon et al., 2002; Harker and Whishaw,…”
Background
- Authors
- Bussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M.
- Affiliations
- University of Cambridge (GB)
- National Institutes of Health (US)
- Corresponding author
- Bussey, T.J.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 62
- Issue
- 3
- Pages
- 1191-1203
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC3168710
- OpenAlex
- W2099186316
- Cited by
- 299
- References
- 210
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 55 · 2020: 27 · 2019: 19 · 2018: 22 · 2017: 29 · 2016: 18 · 2015: 28 · 2014: 13 · 2013: 16 · 2012: 17
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Commonwealth Trust, Janssen Pharmaceutica
- National Institute on Alcohol Abuse and Alcoholism Intramural Research Program
- Innovative Medicines Initiative Joint Undertaking (IMI) (115008)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, cognitive assessment, rodent models, cognitive enhancement, reward learning, memory, perceptual discrimination, attention, impulsivity, compulsivity, extinction, classical conditioning, flexible batteries, cognitive profile, cognitive therapy
- MeSH terms
- Animals, Cognition Disorders, Computers, Discrimination, Psychological, Disease Models, Animal, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Touch, Mice, Rats, Translational Research, Biomedical
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