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Identification of a novel FGF, FGF-21, preferentially expressed in the liver
Abstract
We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus ( approximately 30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19.
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“FGF21, unlike traditional FGFs, is an endocrine hormone produced and secreted predominantly by the liver [129,130].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [129]
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Metadata
- Authors
- Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Itoh, Nobuyuki
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 1492
- Issue
- 1
- Pages
- 203-206
- ISSN
- 0167-4781 (ISSN-L)
- OpenAlex
- W1989584881
- Cited by
- 847
- References
- 21
- Citations by year
- 2026: 14 · 2025: 48 · 2024: 63 · 2023: 47 · 2022: 41 · 2021: 62 · 2020: 49 · 2019: 56 · 2018: 41 · 2017: 46 · 2016: 53 · 2015: 53 · 2014: 43 · 2013: 34 · 2012: 44
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- FGF21, fibroblast growth factor, liver-specific gene expression, thymus, signal peptide, secreted proteins, cDNA cloning, mouse embryo, FGF19, amino acid sequence identity, tissue distribution
- MeSH terms
- Amino Acid Sequence, Animals, Embryo, Mammalian, Fibroblast Growth Factors, Humans, Liver, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid, DNA, Complementary, Mice
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