Cited by 847Fibroblast Growth Factor ResearchLiver physiology and pathologyConnective Tissue Growth Factor Research

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Nishimura, Tetsuya, Nakatake, Yuhki, Konishi, Morichika, Itoh, Nobuyuki·2000·Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

DOI 10.1016/s0167-4781(00)00067-1

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Abstract

We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus ( approximately 30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19.

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Background
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Authors: Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N.
Affiliations: Kyoto University (JP)
Corresponding author: Itoh, Nobuyuki
ORCID: Nakatake, Yuhki
Konishi, Morichika
Venue: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Publisher: Elsevier BV
Published: 2000-06
Volume: 1492
Issue: 1
Pages: 203-206
ISSN: 0167-4781 (ISSN-L)
DOI: 10.1016/s0167-4781(00)00067-1
OpenAlex: W1989584881
Cited by: 847
References: 21
Citations by year: 2026: 14 · 2025: 48 · 2024: 63 · 2023: 47 · 2022: 41 · 2021: 62 · 2020: 49 · 2019: 56 · 2018: 41 · 2017: 46 · 2016: 53 · 2015: 53 · 2014: 43 · 2013: 34 · 2012: 44
FWCI: 4.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Keywords: FGF21, fibroblast growth factor, liver-specific gene expression, thymus, signal peptide, secreted proteins, cDNA cloning, mouse embryo, FGF19, amino acid sequence identity, tissue distribution
MeSH terms: Amino Acid Sequence, Animals, Embryo, Mammalian, Fibroblast Growth Factors, Humans, Liver, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid, DNA, Complementary, Mice

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

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