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Identification of a novel FGF, FGF-21, preferentially expressed in the liver
Abstract
We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus ( approximately 30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19.
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“FGF21, unlike traditional FGFs, is an endocrine hormone produced and secreted predominantly by the liver [129,130].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [129]
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Cites
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
Nielsen, H., Engelbrecht, J., Brunak, S., & von HEIJNE, G. (1997) · Protein Engineering Design and Selection · doi:10.1093/protein/10.1.1 · Cited by 5,343
Frohman, M. A., Dush, M. K., & Martin, G. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8998 · Cited by 4,554
THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS
Burgess, W. H., & Maciag, T. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.003043 · Cited by 1,921
The roles of FGFs in the early development of vertebrate limbs.Preprint
Martin, G. (1998) · Genes & Development · doi:10.1101/gad.12.11.1571 · Cited by 676
Miyamoto, M., Naruo, K., Seko, C., Matsumoto‐Yoshitomi, S., Kondo, T., & Kurokawa, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4251-4259.1993 · Cited by 422
Tanaka, A., Miyamoto, K., Minamino, N., Takeda, M., Sato, B., Matsuo, H., & Matsumoto, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.8928 · Cited by 398
Smallwood, P. M., Muñoz-Sanjuán, I., Tong, P. Y., Macke, J. P., Hendry, S. H. C., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9850 · Cited by 395
The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function
McKeehan, W. L., Wang, F., & Kan, M. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)61031-4 · Cited by 392
The fibroblast growth factor family.
Baird, A., & Klagsbrun, M. (1991) · PubMed · Cited by 322
Yamasaki, M., Miyake, A., Tagashira, S., & Itoh, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.15918 · Cited by 288
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The Potential Roles of Myokines in Adipose Tissue Metabolism with Exercise and Cold Exposure
Jiang, S., Bae, J. H., Wang, Y., & Song, W. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911523 · Cited by 20
Fibroblast Growth Factor 21: A Fascinating Perspective on the Regulation of Muscle Metabolism
Li, S., Chen, J., Wei, P., Zou, T., & You, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316951 · Cited by 19
Sui, Y., Liu, Q., Xu, C., Ganesan, K., Ye, Z., Li, Y., Wu, J., Du, B., Gao, F., Song, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06386-8 · Cited by 19
Wang, J., Zhong, M.-Y., Liu, Y., Yu, J.-Y., Wang, Y., Zhang, X., & Sun, H. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01417-2 · Cited by 19
WANG, M., Zhao, S.-P., & TAN, M. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4749 · Cited by 18
FGF-21: promising biomarker for detecting ketosis in dairy cows
Xu, C., Xu, Q., Chen, Y., Yang, W., Xia, C., Yu, H., Zhu, K., Shen, T., & Zhang, Z. (2016) · Veterinary Research Communications · doi:10.1007/s11259-015-9650-5 · Cited by 19
Markers in Nonalcoholic Steatohepatitis
Armutçu, F., Akyol, S., Uçar, F., Erdoğan, S., & Akyol, Ö. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-407680-8.00004-x · Cited by 19
Liu, X., Wang, Y., Zhao, S., & Li, X. (2017) · BioMed Research International · doi:10.1155/2017/1648715 · Cited by 19
Diabetes Mellitus: New Challenges and Innovative Therapies
Sena, C. M., Bento, C. F., Pereira, P., Marquês, F., & Seiça, R. M. F. (2013) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-94-007-5971-8_3 · Cited by 20
Fibroblast growth factors in myocardial ischemia / reperfusion injury and ischemic preconditioning
Cuevas, P., Carceller, F., & Giménez-Gallego, G. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00146.x · Cited by 18
Zhou, D., Shi, Y., Zhang, D., Zuo, J., Zeng, C., Mamtawla, G., Huang, L., Gao, X., Zhang, L., & Wang, X. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103333 · Cited by 18
Fibroblast growth factor 21: update on genetics and molecular biology
Barros, D. R., & Hegele, R. A. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000960 · Cited by 18
Deng, X., Zhang, H., Chen, W., & Wang, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02520-5 · Cited by 18
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition
Reilly, S. M., Abu-Odeh, M., Ameka, M., DeLuca, J. H., Naber, M. C., Dadpey, B., Ebadat, N., Gomez, A. V., Peng, X., Poirier, B., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145546 · Cited by 18
Yang, N., Zhang, Y., Huang, Y., Yan, J., Qian, Z., Li, H., Luo, P., Yang, Z. L., Luo, M., Wei, X., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166558 · Cited by 18
Play down protein to play up metabolism?
Müller, T. D., & Tschöp, M. H. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77508 · Cited by 17
Fibroblast growth factors 19 and 21 in acute liver damage
Shan, Z., Álvarez‐Sola, G., Uriarte, I., Arechederra, M., Fernández‐Barrena, M. G., Berasain, C., Ju, C., & Avila, M. A. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.26 · Cited by 19
Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21
Pol, C. J., Pollak, N. M., Jurczak, M. J., Zacharia, E. M., Karagiannides, I., Kyriazis, I. D., Ntziachristos, P., Scerbo, D. A., Brown, B. R., Aifantis, I., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.010 · Cited by 18
Lee, D., Tomita, Y., Miwa, Y., Jeong, H., Mori, K., Tsubota, K., & Kurihara, T. (2021) · Pharmaceuticals · doi:10.3390/ph14030223 · Cited by 18
Huang, W., Chen, C., Lin, T., Kuo, C., Huang, H., Huang, P., & Lin, S. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17273 · Cited by 18
Jung, Y. S., Lee, J.-M., Kim, D., Lee, Y. S., Kim, K.-S., Kim, Y., Kim, J., Lee, M., Lee, I., Kim, S. H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159425 · Cited by 18
Metabolic remodeling induced by mitokines in heart failure
Duan, J., Chen, Z., Wu, Y., Zhu, B., Yang, L., & Yang, C. (2019) · Aging · doi:10.18632/aging.102247 · Cited by 17
MiR‐21‐3p Inhibits Adipose Browning by Targeting FGFR1 and Aggravates Atrial Fibrosis in Diabetes
Pan, J., Lin, H., Yu, J., Zhang, H., Zhang, J.-F., Wang, C.-Q., & Gu, J. F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9987219 · Cited by 17
Influence of Adipokines on Metabolic Dysfunction and Aging
Park, S., & Shimokawa, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040873 · Cited by 20
Sandoval, V., Rodríguez‐Rodríguez, R., Martínez‐Garza, Ú., Rosell‐Cardona, C., Lamuela-Raventós, R. M., Marrero, P. F., Haro, D., & Relat, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700606 · Cited by 17
Moro, J., Chaumontet, C., Even, P. C., Blais, A., Piedcoq, J., Gaudichon, C., Tomé, D., & Azzout‐Marniche, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-91274-4 · Cited by 17
Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 18
Phelps, M., Stuelsatz, P., & Yablonka‐Reuveni, Z. (2016) · FEBS Journal · doi:10.1111/febs.13682 · Cited by 17
Hu, W., He, J., Fu, W., Wang, C., Yue, H., Gu, J., Zhang, H., & Zhang, Z. (2018) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2018.08.005 · Cited by 17
Seo, Y., Lee, K., Chei, S., Jeon, Y., & Lee, B.-Y. (2019) · Marine Drugs · doi:10.3390/md17070407 · Cited by 17
Antonellis, P. J., Kharitonenkov, A., & Adams, A. C. (2014) · Journal of Animal Science · doi:10.2527/jas.2013-7076 · Cited by 15
Bo, W., Ma, Y., Feng, L., Yu, M., Zhang, L., Cai, M., Song, W., Xi, Y., & Tian, Z. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2023 · Cited by 17
Ahmed, T. A., Ahmed, S. M., Elkhenany, H. A., El-Desouky, M. A., Magdeldin, S., Osama, A., Anwar, A. M., Mohamed, I. K., Abdelgawad, M. E., Hanna, D. H., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03643-1 · Cited by 18
The crosstalk between fibroblast growth factor 21 (FGF21) system and substance use
Wang, T., Tyler, R. E., Ilaka, O., Cooper, D., Farokhnia, M., & Leggio, L. (2024) · iScience · doi:10.1016/j.isci.2024.110389 · Cited by 18
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Umberger, T. S., Sloan, J. H., Chen, J., Cheng, C., Siegel, R. W., Qian, Y., Troutt, J. S., & Konrad, R. J. (2014) · Bioanalysis · doi:10.4155/bio.14.241 · Cited by 16
Xiao, F., Zeng, J., Huang, P., Yan, B., Zeng, X., Liu, C., Shi, X., Wang, L., Song, H., Lin, M., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00800 · Cited by 16
Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients
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Epperlein, S., Gebhardt, C., Rohde, K., Chakaroun, R., Patt, M., Schamarek, I., Kralisch, S., Heiker, J. T., Scholz, M. R., Stümvoll, M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9040345 · Cited by 16
Garcia‐Caraballo, S., Comhair, T. M., Dejong, C. H. C., Lamers, W. H., & Köhler, E. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.04.022 · Cited by 16
Ong, K. L., O'Connell, R. L., Januszewski, A. S., Jenkins, A. J., Xu, A., SULLIVAN, D. R., Barter, P. J., Scott, R. S., Taskinen, M., Waldman, B., et al. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.270876 · Cited by 16
Trusz, G. J. (2024) · Differentiation · doi:10.1016/j.diff.2024.100793 · Cited by 15
Shi, X., Zheng, Q., Wang, X., Guo, W., Lin, Z., Gao, Y., Shore, E. A., Martin, R. C. G., Lv, G., & Li, Y. (2024) · Science Advances · doi:10.1126/sciadv.ado9311 · Cited by 15
Lombardi, G., Sansoni, V., & Banfi, G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.07.11 · Cited by 17
Photoperiodic regulation of FGF21 production in the Siberian hamster
Samms, R. J., Fowler, M. J., Cooper, S., Emmerson, P. J., Coşkun, T., Adams, A. C., Kharitonenkov, A., Tsintzas, K., & Ebling, F. J. P. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.013 · Cited by 15
Fgf21 regulates T-cell development in the neonatal and juvenile thymus
Nakayama, Y., Masuda, Y., Ohta, H., Tanaka, T., Washida, M., Nabeshima, Y., Miyake, A., Itoh, N., & Konishi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00349-8 · Cited by 15
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Brucato, S., Bocquet, J., & Villers, C. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02672.x · Cited by 15
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Forst, T. M., Block, C. E. M. D., Prato, S. D., Frías, J. P., Lautenbach, A., Ludvik, B. H., Marinez, M., Mathieu, C., Müller, T. D., & Schnell, O. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16247 · Cited by 15
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Ye, X.-F., Qi, J., Wu, Y., Yu, D., Xu, P., Li, S., Zhu, S., Wu, Q., Ren, G., & Li, D. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.09.001 · Cited by 14
Yuan, X., Huang, H., Huang, Y., Wang, J., Yan, J., Ding, L., Zhang, C., & Zhang, L. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217694435 · Cited by 14
Kiluk, P., Baran, A. M., Kaminski, T. W., Maciaszek, M., & Flisiak, I. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122206 · Cited by 15
Xu, P., Zhang, Y., Jiang, X., Li, J., Song, L., Khoso, M. H., Liu, Y., Wu, Q., Ren, G., & Li, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155598 · Cited by 14
Anuwatmatee, S., Allison, M., Shlipak, M. G., McClelland, R. L., Kramer, H., Tang, S., Hou, L., Rye, K., & Ong, K. L. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy120 · Cited by 14
Hu, Q., Wang, C., Liu, F., He, J., Fen, W., Wang, W., & You, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.159 · Cited by 14
Pereira, R. O., & McFarlane, S. I. (2019) · International Journal of Clinical Research & Trials · doi:10.15344/2456-8007/2019/136 · Cited by 14
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Zhang, T., Jiang, D., Zhang, X., Chen, L., Jiang, J., Zhang, C., Li, S., & Li, Q. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01842-0 · Cited by 13
Wang, J., Meng, X., Jialun, Y., Tang, Y., Zeng, F., Wang, Y., Chen, Z., Chen, D., Zou, R., & Liu, W. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04350-w · Cited by 15
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Kim, S. Q., Spann, R. A., Khan, M. S. H., Berthoud, H., Münzberg, H., Albaugh, V. L., He, Y., McDougal, D. H., Soto, P. L., Yu, S., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110010 · Cited by 10
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Chen, S., Li, H., Zhang, J., Jiang, S., Zhang, M., Xu, Y., Dong, K., Yang, Y., Fang, Q., & Jia, W. (2017) · BioMed Research International · doi:10.1155/2017/8402035 · Cited by 12
Marchelek‐Myśliwiec, M., Dziedziejko, V., Dołęgowska, K., Pawlik, A., Safranow, K., Stępniewska, J., Wiśniewska, M., Małyszko, J., & Ciechanowski, K. (2020) · Journal of Applied Biomedicine · doi:10.32725/jab.2020.005 · Cited by 12
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Liu, Y., Chen, Q., Li, Y., Bi, L., He, Z., Shao, C., Jin, L., Peng, R., & Zhang, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121015 · Cited by 12
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Kondo, Y., Komaba, H., & Fukagawa, M. (2020) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1780918 · Cited by 12
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Translocation of fibroblast growth factor‐10 and its receptor into nuclei of human urothelial cells
Kosman, J., Carmean, N., Leaf, E. M., Dyamenahalli, K., & Bassuk, J. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21330 · Cited by 12
Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism
Patton, A., Khan, F. H., & Kohli, R. (2017) · Digestive Diseases · doi:10.1159/000450910 · Cited by 13
Mia, S., Siokatas, G., Sidiropoulou, R., Hoffman, M., Fragkiadakis, K., Markopoulou, E., Elesawy, M., Roy, R., Blair, S., Kuwabara, Y., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102125 · Cited by 11
Damanti, S., Sciorati, C., LORENZO, R. D., Avola, A., Ruggiero, M. P., Santoro, S., Senini, E., Messina, M., Farina, F., Festorazzi, C., et al. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112124 · Cited by 13
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Liu, X., Jing, M., Yang, Y., Jin, Q., Feng, B., Zhang, P., Niu, C., Hu, X., & Huang, Z. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00429-0 · Cited by 14
Ghanem, M., Archer, G., Crestani, B., & Mailleux, A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108669 · Cited by 12
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Jin, Z., Mao, Y., Guo, Q., Yin, Y., Kiram, A., Zhou, D., Yang, J., Zhou, Z., Xue, J., Feng, Z., et al. (2024) · Research · doi:10.34133/research.0465 · Cited by 13
Kikai, M., Yamada, H., Wakana, N., Terada, K., Yamamoto, K., Wada, N., Motoyama, S., Saburi, M., Sugimoto, T., Irie, D., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.185 · Cited by 11
Gómez-Sámano, M. Á., Vargas-Abonce, V. P., Martínez‐Sánchez, F. D., Palacios-Báez, L., Vera-Zertuche, J. M., Navarro-Flores, M. F., Morales-García, M., Fonseca-Correa, J. I., Zuarth-Vázquez, J. M., Vega‐Vega, O., et al. (2021) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188211001160 · Cited by 11
Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma
Vachher, M., Bansal, S., Kumar, B., Yadav, S., Arora, T. K., Wali, N. M., & Burman, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30252 · Cited by 11
Qian, Z., Zhang, Y., Yang, N., Nie, H., Yang, Z. L., Luo, P., Wei, X., Guan, Y., Huang, Y., Yan, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.984828 · Cited by 11
Corbee, R. J., van Everdingen, D. L., Kooistra, H. S., & Penning, L. C. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1086987 · Cited by 11
Endocrine FGFs and their signaling in the brain: Relevance for energy homeostasis
Zangerolamo, L., Carvalho, M. U. W. B. D., Velloso, L. A., & Barbosa, H. C. L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176248 · Cited by 11
Eissa, L. A., Abdel‐Rahman, N., & Eraky, S. M. (2015) · Egyptian Journal of Basic and Applied Sciences · doi:10.1016/j.ejbas.2015.01.002 · Cited by 11
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Metadata
- Authors
- Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Itoh, Nobuyuki
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 1492
- Issue
- 1
- Pages
- 203-206
- ISSN
- 0167-4781 (ISSN-L)
- OpenAlex
- W1989584881
- Cited by
- 847
- References
- 21
- Citations by year
- 2026: 14 · 2025: 48 · 2024: 63 · 2023: 47 · 2022: 41 · 2021: 62 · 2020: 49 · 2019: 56 · 2018: 41 · 2017: 46 · 2016: 53 · 2015: 53 · 2014: 43 · 2013: 34 · 2012: 44
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- FGF21, fibroblast growth factor, liver-specific gene expression, thymus, signal peptide, secreted proteins, cDNA cloning, mouse embryo, FGF19, amino acid sequence identity, tissue distribution
- MeSH terms
- Amino Acid Sequence, Animals, Embryo, Mammalian, Fibroblast Growth Factors, Humans, Liver, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid, DNA, Complementary, Mice
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