Optimizing scale-up fermentation processes

High cell-density culture of Escherichia coli

Lee, S. Y. (1996) · Trends in biotechnology · doi:10.1016/0167-7799(96)80930-9 · Cited by 893 · see citing works

Physiological responses to mixing in large scale bioreactors

Enfors, S., Jahic, M., Rozkov, A., Xu, B., Hecker, M., Jürgen, B., Krüger, E., Schweder, T., Hamer, G., O'Beirne, D., et al. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00365-5 · Cited by 480 · see citing works

Strategies for optimal synthesis and secretion of heterologous proteins in the methylotrophic yeast Pichia pastoris

Sreekrishna, K. T., Brankamp, R. G., Kropp, K. E., Blankenship, D. T., Tsay, J. T., Smith, P. L., Wierschke, J. D., Subramaniam, A., & Birkenberger, L. A. (1997) · Gene · doi:10.1016/s0378-1119(96)00672-5 · Cited by 432 · see citing works

Incompatibility of Lactobacillus Vectors with Replicons Derived from Small Cryptic Lactobacillus Plasmids and Segregational Instability of the Introduced Vectors

Posno, M., Leer, R. J., van Luijk, N., van Giezen, M. J., Heuvelmans, P., Lokman, B. C., & Pouwels, P. H. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.6.1822-1828.1991 · Cited by 187 · see citing works

Copy number and the stability of 2-micron circle-based artificial plasmids of Saccharomyces cerevisiae

Futcher, A. B., & Cox, B. S. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.1.283-290.1984 · Cited by 182 · see citing works

Regulation of Carbon Metabolism in Saccharomyces cerevisiae and Related Yeasts

Käppeli, O. (1987) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60239-8 · Cited by 175 · see citing works

Integration and expression of alpha-amylase and endoglucanase genes in the Lactobacillus plantarum chromosome

Scheirlinck, T., Mahillon, J., Joos, H., D’Haese, P. C., & Michiels, F. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.9.2130-2137.1989 · Cited by 140 · see citing works

Large scale production of cyclohexanone monooxygenase from Escherichia coli TOP10 pQR239

O’Sullivan, L., Patel, S., Ward, J. M., Woodley, J. M., & Doig, S. D. (2001) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(00)00320-3 · Cited by 125 · see citing works

The parB (hok/sok) Locus of Plasmid R1: A General Purpose Plasmid Stabilization System

Gerdes, K. (1988) · Nature Biotechnology · doi:10.1038/nbt1288-1402 · Cited by 121 · see citing works

Strategies for improving plasmid stability in genetically modified bacteria in bioreactors

Kumar, P. (1991) · Trends in biotechnology · doi:10.1016/0167-7799(91)90090-5 · Cited by 100 · see citing works

Industrial production of heterologous proteins by fed-batch cultures of the yeast Saccharomyces cereuisiae

Mendoza-Vega, O., Sabatié, J., & Brown, S. (1994) · FEMS Microbiology Reviews · doi:10.1016/0168-6445(94)90070-1 · Cited by 84 · see citing works

Mixed-feed exponential feeding for fed-batch culture of recombinant methylotrophic yeast

d′Anjou, M., & Daugulis, A. J. (2000) · Biotechnology Letters · doi:10.1023/a:1005612415737 · Cited by 75 · see citing works

Expression of Recombinant Galactose Oxidase by Pichia pastoris

Whittaker, M. M., & Whittaker, J. W. (2000) · Protein Expression and Purification · doi:10.1006/prep.2000.1287 · Cited by 73 · see citing works

Structural and functional analysis of two cryptic plasmids from Lactobacillus pentosus MD353 and Lactobacillus plantarum ATCC 8014

Leer, R. J., van Luijk, N., Posno, M., & Pouwels, P. H. (1992) · Molecular and General Genetics MGG · doi:10.1007/bf00283847 · Cited by 69 · see citing works

Effects of temperature and dilution rate on the copy number of recombinant plasmid in continuous culture of Bacillus stearothermophilus (pLP11)

Koizumi, J., Monden, Y., & Aiba, S. (1985) · Biotechnology and Bioengineering · doi:10.1002/bit.260270522 · Cited by 59 · see citing works

Escherichia coli growth and plasmid copy numbers in continuous cultivations

Reinikainen, P., & Virkaj�rvi, I. (1989) · Biotechnology Letters · doi:10.1007/bf01031568 · Cited by 34 · see citing works

Growth, plasmid stability and ?-amylase production in batch fermentations using a recombinantBacillus subtilis strain

Pinches, A., Lonw, M. E., & Watson, T. G. (1985) · Biotechnology Letters · doi:10.1007/bf01040197 · Cited by 22 · see citing works

Validation of fermentation processes.

Lubiniecki, A. S., Gardner, A., Smith, T. M., Wang, W. K., McAllister, P., & Federici, M. M. (2003) · PubMed · Cited by 11 · see citing works

Expression of heterologous proteins inPichia pastoris: a useful experimental tool in protein engineering and production

Daly, R., & Hearn, M. T. W. (2004) · Journal of Molecular Recognition · doi:10.1002/jmr.687 · Cited by 742 · see citing works

Industrial production of amino acids by coryneform bacteria

Hermann, T. (2003) · Journal of Biotechnology · doi:10.1016/s0168-1656(03)00149-4 · Cited by 606 · see citing works

Guidelines and Cost Analysis for Catalyst Production in Biocatalytic Processes

Tufvesson, P., Ramos, J. L., Nordblad, M., & Woodley, J. M. (2010) · Organic Process Research & Development · doi:10.1021/op1002165 · Cited by 500 · see citing works

Optimization and scale up of industrial fermentation processes

Schmidt, F. R. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0003-0 · Cited by 362 · see citing works

Endophytes as in vitro production platforms of high value plant secondary metabolites

Venugopalan, A., & Srivastava, S. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.07.004 · Cited by 221 · see citing works

Manufacturing of recombinant therapeutic proteins in microbial systems

Graumann, K., & Premstaller, A. (2006) · Biotechnology Journal · doi:10.1002/biot.200500051 · Cited by 208 · see citing works

Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery

Tiwari, P., & Bae, H. (2022) · Microorganisms · doi:10.3390/microorganisms10020360 · Cited by 206 · see citing works

Bacterial cellulose production by Gluconacetobacter xylinus by employing alternative culture media

Jozala, Â. F., Pértile, R. A. N., dos Santos, C. A., Santos‐Ebinuma, V. C., Seckler, M. M., Gama, M., & Pessoa, A. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-6232-3 · Cited by 197 · see citing works

An Overview on Fungal Cellulases with an Industrial Perspective

SREEDHARAN, S. K. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000461 · Cited by 174 · see citing works

Process considerations for the scale-up and implementation of biocatalysis

Tufvesson, P., Fu, W., Jensen, J. S., & Woodley, J. M. (2010) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2010.01.003 · Cited by 165 · see citing works

Enzymes for pharmaceutical and therapeutic applications

Meghwanshi, G. K., Kaur, N., Verma, S., Dabi, N. K., Vashishtha, A., Charan, P. D., Purohit, P., Bhandari, H. S., Bhojak, N., & Kumar, R. (2020) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1919 · Cited by 149 · see citing works

Effect of aeration and agitation rates and scale-up on oxygen transfer coefficient, kLa in exopolysaccharide production from Enterobacter cloacae WD7

Bandaiphet, C., & Prasertsan, P. (2006) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.03.004 · Cited by 146 · see citing works

Load following with Small Modular Reactors (SMR): A real options analysis

Locatelli, G., Boarin, S., Pellegrino, F., & Ricotti, M. E. (2014) · Energy · doi:10.1016/j.energy.2014.11.040 · Cited by 123 · see citing works

Novel, Versatile, and Tightly Regulated Expression System for <i>E</i> <i>scherichia coli</i> Strains

Choi, Y. J., Morel, L., Le François, T., Bourque, D., Bourget, L., Groleau, D., Massie, B., & Míguez, C. B. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00413-10 · Cited by 94 · see citing works

Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review

Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works

Focused Review: Cytotoxic and Antioxidant Potentials of Mangrove-Derived Streptomyces

Ser, H., Tan, L. T., Law, J. W., Chan, K., Duangjai, A., Saokaew, S., Pusparajah, P., Mutalib, N. A., Khan, T. M., Goh, B. H., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02065 · Cited by 84 · see citing works

Improvement of a two-stage fermentation process for docosahexaenoic acid production by Aurantiochytrium limacinum SR21 applying statistical experimental designs and data analysis

Rosa, S. M., Soria, M. A., Vélez, C. G., & Galvagno, M. A. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2009.11.056 · Cited by 78 · see citing works

Scale-up Problems for the Large Scale Production of Algae

da Silva, T. L., & Reis, A. (2015) · Algal Biorefinery: An Integrated Approach · doi:10.1007/978-3-319-22813-6_6 · Cited by 76 · see citing works

Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems

Funke, M., Buchenauer, A., Mokwa, W., Kluge, S., Hein, L., Müller, C., Kensy, F., & Büchs, J. (2010) · Microbial Cell Factories · doi:10.1186/1475-2859-9-86 · Cited by 73 · see citing works

Process optimization for butanol production from developed rice straw hydrolysate using Clostridium acetobutylicum MTCC 481 strain

Ranjan, A., Mayank, R., & Moholkar, V. S. (2012) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-012-0062-2 · Cited by 55 · see citing works

Production of heterologous protein byMethylobacterium extorquensin high cell density fermentation

Bélanger, L., Figueira, M. M., Bourque, D., Morel, L., Béland, M., Laramée, L., Groleau, D., & Mı́guez, C. B. (2004) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00956-x · Cited by 54 · see citing works

Panorama of poly-ε-lysine

Bankar, S. B., & Singhal, R. S. (2013) · RSC Advances · doi:10.1039/c3ra22596h · Cited by 54 · see citing works

Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes – a review

Fernandes, P. C. D. B., & Cabral, J. M. S. (2006) · Biocatalysis and Biotransformation · doi:10.1080/10242420600667684 · Cited by 52 · see citing works

Investigation on the exopolysaccharide production from blueberry juice fermented with lactic acid bacteria: Optimization, fermentation characteristics and Vis-NIR spectral model

Yang, S., Tao, Y., Maimaiti, X., Su, W., Liu, X., Zhou, J., & Fan, L. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139589 · Cited by 46 · see citing works

The persistence potential of transferable plasmids

Wang, T., & You, L. (2020) · Nature Communications · doi:10.1038/s41467-020-19368-7 · Cited by 46 · see citing works

Scale-up for bulk production of vaccine against meningococcal disease

Baart, G. J. E., de Jong, G., Philippi, M. C., Riet, K. V., van der Pol, L. A., Beuvery, E. C., TRAMPER, J., & Martens, D. E. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.06.008 · Cited by 38 · see citing works

Optimization of Aeration and Agitation Rate for Lipid and Gamma Linolenic Acid Production byCunninghamella bainieri2A1 in Submerged Fermentation Using Response Surface Methodology

Saad, N., Abdeshahian, P., Kalil, M. S., Yusoff, W. M. W., & Hamid, A. A. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/280146 · Cited by 36 · see citing works

Statistical optimization for production of carboxymethylcellulase of Bacillus amyloliquefaciens DL-3 by a recombinant Escherichia coli JM109/DL-3 from rice bran using response surface method

Lee, Y.-J., Kim, H.-J., Gao, W., Chung, C., & Lee, J.-W. (2012) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-011-0258-5 · Cited by 34 · see citing works

Advancing precision fermentation: Minimizing power demand of industrial scale bioreactors through mechanistic modelling

Jahanian, A., Ramirez, J., & O’Hara, I. M. (2024) · Computers & Chemical Engineering · doi:10.1016/j.compchemeng.2024.108755 · Cited by 32 · see citing works

Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases

Hull, C. M., Warrilow, A. G. S., Rolley, N. J., Price, C. L., Donnison, I. S., Kelly, D. E., & Kelly, S. L. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0904-z · Cited by 32 · see citing works

Effect of mass transfer on biodesulfurization kinetics of alkylated forms of dibenzothiophene by Pseudomonas putida CECT5279

Boltes, K., del Águila, R. A., & García‐Calvo, E. (2012) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.3877 · Cited by 29 · see citing works

Development of an industrial medium and a novel fed-batch strategy for high-level expression of recombinant β-mananase by Pichia pastoris

Zheng, J. M., Zhao, W. L., Guo, N., Lin, F.-L., Tian, J., Wu, L., & Zhou, H. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.05.065 · Cited by 28 · see citing works

Effect of aeration and agitation rates on alkaline protease production by bacillus licheniformis UV-9 mutant

Nadeem, M. S., Qazi, J. I., & Baig, S. (2009) · Turkish Journal of Biochemistry · Cited by 28 · see citing works

High-throughput process development from gene cloning to protein production

Sun, M., Gao, X., Liu, X., Yang, Y., Ledesma‐Amaro, R., & Bai, Z. (2023) · Microbial Cell Factories · doi:10.1186/s12934-023-02184-1 · Cited by 27 · see citing works

Desolvation-induced formation of recombinant camel serum albumin-based nanocomposite for glutathione colorimetric determination

Zhang, J., Pei, W., Xu, Q., Jiang, H., & Chen, J. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131417 · Cited by 26 · see citing works

Glycerol as a substrate for actinobacteria of biotechnological interest: Advantages and perspectives in circular economy systems

Costa‐Gutierrez, S. B., Saez, J. M., Aparicio, J. D., Raimondo, E. E., Benimeli, C. S., & Polti, M. A. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130505 · Cited by 25 · see citing works

QbD Based Media Development for the Production of Fab Fragments in E. coli

Kumar, D., Batra, J., Komives, C., & Rathore, A. S. (2019) · Bioengineering · doi:10.3390/bioengineering6020029 · Cited by 24 · see citing works

Response of Maize to Applied Soil Zinc

Tariq, M., Khan, M. A., & Perveen, S. (2002) · Asian Journal of Plant Sciences · doi:10.3923/ajps.2002.476.477 · Cited by 22 · see citing works

Manufacturing, regulatory and commercial challenges of biopharmaceuticals production: a Finnish perspective

Närhi, M., & Nordström, K. M. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.11.006 · Cited by 20 · see citing works

Physiological and metabolic traits of Taxol biosynthesis of endophytic fungi inhabiting plants: Plant-microbial crosstalk, and epigenetic regulators

Mohamed, N. Z., Shaaban, L., Safan, S., & El‐Sayed, A. S. A. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127385 · Cited by 18 · see citing works

A review of the pharmaceutical applications of endophytic fungal secondary metabolites

Enyi, E. O., Chigozie, V. U., Okezie, U. M., Nkechi, U. T., & Oko, A. O. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2423036 · Cited by 17 · see citing works

Optimization strategies for enhanced production of single cell protein: recent advances and perspectives

Rajput, S. D., Pandey, N., & Keshavkant, S. (2024) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-024-09706-2 · Cited by 17 · see citing works

Scale-up thermostable α-amylase production in lab-scale fermenter using rice husk as an elicitor by Bacillus licheniformis-AZ2 isolated from Qinarje Hot Spring (Ardebil Prov. of Iran)

Deljou, A., Arezi, I., & Khanahmadi, M. (2018) · Periodicum Biologorum · doi:10.18054/pb.v120i1.6775 · Cited by 17 · see citing works

Optimization of Fermentation Conditions for Elevating Limonene Production with Engineered Rhodosporidium toruloides

Zhao, D., Gao, Q., Zheng, X., Liu, S., Qi, Q., Wang, X., & Yang, X. (2023) · Fermentation · doi:10.3390/fermentation9050431 · Cited by 15 · see citing works

Single‐chain antibody fragment production in Pichia pastoris: Benefits of prolonged pre‐induction glycerol feeding

Khatri, N. K., Rother, D., Trentmann, O., Neubauer, P. B., & Hoffmann, F. (2011) · Biotechnology Journal · doi:10.1002/biot.201000193 · Cited by 15 · see citing works

Promotion of plasmid maintenance by heterogeneous partitioning of microbial communities

Weiss, A., Wang, T., & You, L. (2023) · Cell Systems · doi:10.1016/j.cels.2023.09.002 · Cited by 13 · see citing works

Scale up and optimization of cholesterol oxidase production from Streptomyces rimosus MTCC 10792 in a 3-L bioreactor

Srivastava, A., Singh, V., & Tripathi, C. K. M. (2018) · Environmental Sustainability · doi:10.1007/s42398-018-0008-0 · Cited by 12 · see citing works

Comparative analysis of hydrodynamic and reactor design effects on performance in bioreactors

Shah, P., Nagpal, S., Kwak, D. H., Kim, J. H., Cho, J. H., Kim, J., Roh, K., Park, S. M., & Kwon, J. S. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.171731 · Cited by 11 · see citing works

Construction of a constitutively active type III secretion system for heterologous protein secretion

Liang, J. M., Burdette, L. A., Wong, H. T., & Tullman‐Ercek, D. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12411-9 · Cited by 11 · see citing works

Acetobacter senegalensis isolated from mango fruits: Its polyphasic characterization and adaptation to protect against stressors in the industrial production of vinegar: A review

Ndoye, B., Shafiei, R., Sanaei, N. S., Cleenwerck, I., Somda, M. K., Dicko, M. H., Tounkara, L. S., Guiro, A. T., Delvigne, F., & Thonart, P. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15495 · Cited by 11 · see citing works

α-Amylase Production by Bacillus amyloliquefaciens Using Agro Wastes as Feed Stock

Gangadharan, D., Nampoothiri, K. M., & Pandey, A. (2011) · University of Zagreb University Computing Centre (SRCE) · Cited by 11 · see citing works

Enhanced production of carboxymethylcellulase by Cellulophaga lytica LBH-14 in pilot-scale bioreactor under optimized conditions involved in dissolved oxygen

Cao, W., Lee, S.-U., Li, J., & Lee, J.-W. (2013) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-012-0219-5 · Cited by 10 · see citing works

High-titer production of staurosporine by heterologous expression and process optimization

Zhang, Z., Yang, S., Li, Z., Wu, Y., Tang, J., Feng, M., & Chen, S. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12661-7 · Cited by 10 · see citing works

Disruption of Protease Genes in Microbes for Production of Heterologous Proteins

Kour, D., Rana, K. L., Thakur, S., Sharma, S., Yadav, N., Rastegari, A. A., Yadav, A. N., & Saxena, A. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-444-63503-7.00003-6 · Cited by 10 · see citing works

The song remains the same. The lab bench dilemma of using shaken flasks in microbial biotransformation experiments

de Oliveira, N. S., da Silva, G. P. L., Júnior, O. F., Peña, L. C., Bianchini, L. F., Parahitiyawa, N., & Rosa, E. A. R. (2023) · Biocatalysis and Biotransformation · doi:10.1080/10242422.2023.2284116 · Cited by 9 · see citing works

Statistical optimization of simple culture conditions to produce biomass of an ochratoxigenic mould biocontrol yeast strain

Pelinski, R., Cerrutti, P., Ponsone, M. L., Chulze, S., & Galvagno, M. A. (2012) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2012.03217.x · Cited by 9 · see citing works

Continuous Fermentation for Biopharmaceuticals?

Mears, L., Feldman, H., Falco, F. C., Bach, C., Wu, M., Nørregaard, A., & Gernaey, K. V. (2017) · Wiley eBooks · doi:10.1002/9781119001348.ch6 · Cited by 9 · see citing works

Light-Driven Chemical Production with Quantum Dot-Biohybrid System: A Review

Lee, B.-H., Lee, I., Kim, G., Kim, J., Panpranot, J., & Lee, D. C. (2024) · JOURNAL OF CHEMICAL ENGINEERING OF JAPAN · doi:10.1080/00219592.2024.2419109 · Cited by 8 · see citing works

Current Developments in Industrial Fermentation Processes

Niakousari, M., Razmjooei, M., Nejadmansouri, M., Barba, F. J., Marszałek, K., & Koubaa, M. (2021) · Wiley eBooks · doi:10.1002/9781119505822.ch2 · Cited by 8 · see citing works

Estimation of recombinant protein production in Pichia pastoris based on a constraint-based model

Tortajada, M., Llaneras, F., Ramón, D., & Picó, J. (2012) · Journal of Process Control · doi:10.1016/j.jprocont.2012.03.009 · Cited by 7 · see citing works

Engineering Escherichia coli for l -Threonine Hyperproduction Based on Multidimensional Optimization Strategies

Zhao, Z., You, J., Shi, X., Zhu, R., Yang, F., Xu, M., Shao, M., Zhang, R., Zhao, Y., & Rao, Z. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07607 · Cited by 7 · see citing works

Predicting plasmid persistence in microbial communities by coarse‐grained modeling

Wang, T., Weiss, A., Ha, Y., & You, L. (2021) · BioEssays · doi:10.1002/bies.202100084 · Cited by 6 · see citing works

Bioprocessing of Endophytes for Production of High-Value Biochemicals

Mohinudeen, K., Devan, K., & Srivastava, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-5862-3_17 · Cited by 5 · see citing works

l-Threonine

Rieping, M., & Hermann, T. (2006) · Microbiology monographs · doi:10.1007/7171_2006_065 · Cited by 5 · see citing works

Use of glycerol for the production of actinobacteria with well-known bioremediation abilities

Costa‐Gutierrez, S. B., Aparicio, J. D., Delgado, O. D., Benimeli, C. S., & Polti, M. A. (2021) · 3 Biotech · doi:10.1007/s13205-020-02588-5 · Cited by 5 · see citing works

Enhanced production of heteropolysaccharide-7 by Beijerinckia indica HS-2001 in pilot-scaled bioreactor under optimized conditions involved in dissolved oxygen using sucrose-based medium

Jung, D.-Y., Son, C.-W., Kim, S.-K., Gao, W., & Lee, J. (2013) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-012-0520-5 · Cited by 5 · see citing works

ISOLATION AND IDENTIFICATION OF CHOLESTEROL OXIDASE PRODUCING ACTINOMYCETES FROM EGYPTIAN SOIL FOR A LARGE SCALE FERMENTATION IN SUBMERGED CULTURES

Abdelwahed, N. A. M., Awad, H. M., Said, I. G., Gamal, A. A., Elsayed, E. A., & Hassan, A. A. (2021) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.15414/jmbfs.4152 · Cited by 4 · see citing works

Scale-Up of Engineering Strain for Industrial Applications

Ray, L. B., & Raina, V. (2022) · Springer eBooks · doi:10.1007/978-981-19-3979-2_14 · Cited by 4 · see citing works

Integrated process development ‐ quality by design compliant evaluation of upstream variations at the microscale level

Walther, C., Boras, D., Demmel, L., Berkemeyer, M., Brocard, C., & Dürauer, A. (2017) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5407 · Cited by 4 · see citing works

Ulceroglandular tularemia: a typical case of relapse.

Miller, S. D., Snyder, M. B., Kleerekoper, M., & Grossman, C. H. (1989) · PubMed · Cited by 3 · see citing works

A model-based estimation of the profit function for the continuous fermentation of baker's yeast

Jia, L., Luo, N. S., & Yuan, J. (2007) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/j.cep.2007.02.030 · Cited by 3 · see citing works

Acetate‐containing substrate mixtures improve recombinant protein secretion in Schizosaccharomyces pombe

Klein, T., Heinzle, E., & Schneider, K. P. (2015) · Engineering in Life Sciences · doi:10.1002/elsc.201400192 · Cited by 3 · see citing works

Bench-scale Overproduction and Purification of recombinant GCSF in Escherichia coli fed-batch process

Babaeipour, V., Mofid, M. R., Khanchezar, S., Faraji, F., & Abolghasemi, S. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.70821 · Cited by 3 · see citing works

Condition stabilization for Aspergillus niger FCBP-198 and its hyperactive mutants to yield high titres of α-amylase

Shafique, S., Bajwa, R., & Shafique, S. (2010) · Microbiology · doi:10.1134/s0026261710030021 · Cited by 2 · see citing works

Process development for the obtention and use of recombinant glycosidases: expression, modelling and immobilisation

SERRA, M. T. (2012) · doi:10.4995/thesis/10251/16800 · Cited by 2 · see citing works

Tobacco shoot regeneration from calli in temporary immersion culture for biosynthesis of heterologous biopharmaceuticals

Barretto, S. S. (2014) · Spiral (Imperial College London) · doi:10.25560/44957 · Cited by 2 · see citing works

Downstream processes: Fundamental and novel insights

Ebrahimi, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-819533-8.00007-5 · Cited by 1 · see citing works

Evaluating the effect of the number of generations in IBUN 91.2.98 Leuconostoc mesenteroides cultures on enzyme extract production

Hurtado, G. B., Porras, W. A. V., Sepúlveda, D. J. V., Alvarez, Á. O., & Flórez, G. Y. (2013) · Ingeniería e Investigación · doi:10.15446/ing.investig.v33n1.37669 · Cited by 1 · see citing works

Development and Scale-Up of Waste Biorefineries Systems: Lactic Acid as a Case Study

Sargo, C. R., Silva, M. R., Ikari, L. Z. O. M., Kolling, D. F., Teodoro, J. C., de Morais, E. R., & Filho, C. A. D. O. (2022) · Springer eBooks · doi:10.1007/978-3-031-06562-0_41 · Cited by 1 · see citing works

From Gene to Product: the Advantage of Integrative Biotechnology

Schmidt, F. R. (2010) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse290 · Cited by 1 · see citing works

Bacterial Fermentation for Protease Production in Fermenters: Impact of Oxygen Transfer Characteristics and Rheological Features on Scale up ProcessPreprint

Sriniva, S., Paulraj, M., Velladurai, S., Govindan, K., Puvanakrishnan, R., Esackimuthu, P., Dhandapani, P., & Gopalan, V. (2023) · Research Square · doi:10.21203/rs.3.rs-3118616/v2 · Cited by 1 · see citing works

Enzimas fúngicas extremófilas de aplicación biotecnológica: producción y caracterización de ramnosidasas alcalofílicas de Acremonium murorum y Acrostalagmus luteo-albus y poligalacturonasa acidofílica de Aspergillus kawachii

Rojas, N. L. (2009) · doi:10.35537/10915/2547

Clonagem, expressão e purificação das proteínas de superfície, PsaA e fragmentos de PspA de Streptococcus pneumoniae

da Silva, M. A. (2005) · doi:10.11606/t.87.2005.tde-27102005-163558

Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

Hanora, A. (2005) · Lund University Publications (Lund University)

Construction of low melting point agarose emulsion PCR amplification complex gene sequence

Xu, M., Tan, B., Zhou, W., Wei, T., Zhang, H., & Zhou, D. (2012) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2011.12.001

α-Amylase Production by

Singh, P., Singh, R. V., Gupta, P., & Shrivastava, A. K. (2014)

Efeito da Agitação sobre a Produção de Fruto-oligossacarídeo por Bacillus subtilis natto

Magri, A., Pan, N. C., da Fontoura, I. C. C., de Oliveira, M. R., & Celligoi, M. A. P. C. (2015) · Anais do Simpósio de Bioquímica e Biotecnologia · doi:10.5151/biochem-vsimbbtec-22186

Process Design and Evaluation for Chemicals Based on Renewable Resources

Fu, W. (2012)

Periplasmic expression of D1.3 Fab antibody in E. coli

Arasteh, S. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham)

Determination of peptidase production potential of Bacillus strains isolated from ropey bread and optimisation of some culture conditions for peptidase production

Certel, M., & Erem, F. (2018) · ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology · doi:10.18036/aubtdc.348383

Improved Production of Recombinant Human β-NGF in Escherichia coli – a Bioreactor Scale Study

Hajihassan, Z., Tilko, P. G., & Sadat, S. M. (2018) · Polish Journal of Microbiology · doi:10.21307/pjm-2018-045

Microbial resources and industrial microbial processes design and behavior

Hamdi, M. (2015)

Estudio de la expresión de angiostatina humana recombinante en cepas de Escherichia coli

Niosi, L. (2022) · doi:10.35537/10915/142833

Bacterial Fermentation for Protease Production in Fermenters: Impact of Oxygen Transfer Characteristics and Rheological Features on Scale up ProcessPreprint

Sriniva, S., Paulraj, M., Velladurai, S., Govindan, K., Puvanakrishnan, R., Esackimuthu, P., & Dhandapani, P. (2023) · Research Square · doi:10.21203/rs.3.rs-3118616/v1

Overcoming challenges in microbial drug factory scale-up

Chauhan, P. S., Dadheech, T., & Saxena, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33032-2.00003-4

Recombinant-Enzyme Fermentation

Amid, A., Ismail, N. A., & Jamaluddin, M. J. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-12397-4_6

Introduction to fermentation technology

Ali, A., Afzaal, M., Akram, N., Hailu, G. G., & Bhatia, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-817788-4.00003-3

A conservation-guided physics-informed transfer learning framework for laboratory-to-industrial fermentation prediction

Zhu, H., Yu, Z., Wang, G., Jiang, Q., & Zhong, W. (2026) · Results in Engineering · doi:10.1016/j.rineng.2026.112694

Pilot-scale in situ product recovery of butyric acid from fermentation

Chen, Y., Aromolaran, A., Alherech, M., Singer, C. A., Chirban, L. A., Lyons, R., Woodworth, S. P., Benson, A. F., Chapman, L., Gaston, K., et al. (2026) · Green Chemistry · doi:10.1039/d6gc03281h

Recombinant protein production of abundant larval transcript (ALT-2) in Escherichia coli.

Ashraf, K., Ramalingam, S., Mujeeb, M., & Haider, A. (2013) · DOAJ (DOAJ: Directory of Open Access Journals)

发酵工艺放大的优化

张振龙 (2003) · 国外医学（预防、诊断、治疗用生物制品分册） · doi:10.3760/cma.j.issn.1673-4211.2003.02.005

Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Madhavan, A., Arun, K. B., Sindhu, R., Krishnamoorthy, J., Rajasekharan, R., Sirohi, R., Pugazhendi, A., Awasthi, M. K., Szakács, G., & Binod, P. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01617-z · Cited by 117 · see citing works

Shaping the quality of biopharmaceuticals – a multiscale perspective on the utilization of big data for efficient bioprocess development

Sokolov, M., Ritscher, J., Souquet, J., Broly, H., Morbidelli, M., & Butté, A. (2016) · New Biotechnology · doi:10.1016/j.nbt.2016.06.864

A Multi-Scale Study of Industrial Fermentation Processes and Their Optimization

Zhang, S., Chu, J., & Zhuang, Y. (2004) · Advances in biochemical engineering, biotechnology · doi:10.1007/b13537 · Cited by 46 · see citing works

Model-based strategies for scale-down studies in fed-batch cultivation of Escherichia coli expressing proinsulin

Anane, E. (2019) · DepositOnce · doi:10.14279/depositonce-8297 · Cited by 1 · see citing works