Cited by 102Viral Infectious Diseases and Gene Expression in InsectsFungal and yeast genetics researchProtein purification and stability

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Optimizing scale-up fermentation processes

Thiry, Michel, Cingolani, Doriano·2002·Trends in Biotechnology

DOI 10.1016/s0167-7799(02)01913-3

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Abstract

There are many aims associated with the optimization of fermentation processes. Optimization is expected to increase the yield of the final product but the process must be compliant with good manufacturing practices, the available equipment and the expected final scale of operation. Dealing with genetically modified microorganisms that overproduce recombinant protein has the advantage that the vast majority of the processes use only three different species, namely Escherichia coli, Saccharomyces cerevisiae and Pichia pastoris. Standard processes for each organism are described in textbooks and serve as a basis for the development of a tailored process. This article outlines the general philosophy that we have devised to ensure an efficient approach of scaling up fermentation processes for biopharmaceutical purposes, in a multidisciplinary environment.

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High cell-density culture of Escherichia coli
Lee, S. Y. (1996) · Trends in biotechnology · doi:10.1016/0167-7799(96)80930-9 · Cited by 893
Physiological responses to mixing in large scale bioreactors
Enfors, S., Jahic, M., Rozkov, A., Xu, B., Hecker, M., Jürgen, B., Krüger, E., Schweder, T., Hamer, G., O'Beirne, D., et al. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00365-5 · Cited by 480
Strategies for optimal synthesis and secretion of heterologous proteins in the methylotrophic yeast Pichia pastoris
Sreekrishna, K. T., Brankamp, R. G., Kropp, K. E., Blankenship, D. T., Tsay, J. T., Smith, P. L., Wierschke, J. D., Subramaniam, A., & Birkenberger, L. A. (1997) · Gene · doi:10.1016/s0378-1119(96)00672-5 · Cited by 432
Incompatibility of Lactobacillus Vectors with Replicons Derived from Small Cryptic Lactobacillus Plasmids and Segregational Instability of the Introduced Vectors
Posno, M., Leer, R. J., van Luijk, N., van Giezen, M. J., Heuvelmans, P., Lokman, B. C., & Pouwels, P. H. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.6.1822-1828.1991 · Cited by 187
Copy number and the stability of 2-micron circle-based artificial plasmids of Saccharomyces cerevisiae
Futcher, A. B., & Cox, B. S. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.1.283-290.1984 · Cited by 182
Regulation of Carbon Metabolism in Saccharomyces cerevisiae and Related Yeasts
Käppeli, O. (1987) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60239-8 · Cited by 175
Integration and expression of alpha-amylase and endoglucanase genes in the Lactobacillus plantarum chromosome
Scheirlinck, T., Mahillon, J., Joos, H., D’Haese, P. C., & Michiels, F. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.9.2130-2137.1989 · Cited by 140
Large scale production of cyclohexanone monooxygenase from Escherichia coli TOP10 pQR239
O’Sullivan, L., Patel, S., Ward, J. M., Woodley, J. M., & Doig, S. D. (2001) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(00)00320-3 · Cited by 125
The parB (hok/sok) Locus of Plasmid R1: A General Purpose Plasmid Stabilization System
Gerdes, K. (1988) · Nature Biotechnology · doi:10.1038/nbt1288-1402 · Cited by 121
Strategies for improving plasmid stability in genetically modified bacteria in bioreactors
Kumar, P. (1991) · Trends in biotechnology · doi:10.1016/0167-7799(91)90090-5 · Cited by 100

Show all 18 references

Research works printed but not linked: 2

Murphy, 1977, Design and analysis of industrials experiments, Chem. Eng., 6, 168
Kwanmin, 1989, Scale-down techniques for fermentation, Biopharm., 2, 30

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Rojas, N. L. (2009) · doi:10.35537/10915/2547
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da Silva, M. A. (2005) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.87.2005.tde-27102005-163558
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Hanora, A. (2005) · Lund University Publications (Lund University)
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Xu, M., Tan, B., Zhou, W., Wei, T., Zhang, H., & Zhou, D. (2012) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2011.12.001
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Magri, A., Pan, N. C., da Fontoura, I. C. C., de Oliveira, M. R., & Celligoi, M. A. P. C. (2015) · Anais do Simpósio de Bioquímica e Biotecnologia · doi:10.5151/biochem-vsimbbtec-22186
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Fu, W. (2012)
Periplasmic expression of D1.3 Fab antibody in E. coli
Arasteh, S. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham)
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Certel, M., & Erem, F. (2018) · ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology · doi:10.18036/aubtdc.348383
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Hajihassan, Z., Tilko, P. G., & Sadat, S. M. (2018) · Polish Journal of Microbiology · doi:10.21307/pjm-2018-045
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Hamdi, M. (2015)
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Chauhan, P. S., Dadheech, T., & Saxena, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33032-2.00003-4
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Amid, A., Ismail, N. A., & Jamaluddin, M. J. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-12397-4_6
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Ali, A., Afzaal, M., Akram, N., Hailu, G. G., & Bhatia, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-817788-4.00003-3
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Zhu, H., Yu, Z., Wang, G., Jiang, Q., & Zhong, W. (2026) · Results in Engineering · doi:10.1016/j.rineng.2026.112694
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Chen, Y., Aromolaran, A., Alherech, M., Singer, C. A., Chirban, L. A., Lyons, R., Woodworth, S. P., Benson, A. F., Chapman, L., Gaston, K., et al. (2026) · Green Chemistry · doi:10.1039/d6gc03281h
Recombinant protein production of abundant larval transcript (ALT-2) in Escherichia coli.
Ashraf, K., Ramalingam, S., Mujeeb, M., & Haider, A. (2013) · DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Thiry, M., & Cingolani, D.
Affiliations: Eurogentec (Belgium) (BE)
Venue: Trends in Biotechnology
Publisher: Elsevier BV
Published: 2002-03
Volume: 20
Issue: 3
Pages: 103-105
ISSN: 0167-7799 (ISSN-L)
DOI: 10.1016/s0167-7799(02)01913-3
OpenAlex: W2001751900
Cited by: 102
References: 18
Citations by year: 2026: 4 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 10
FWCI: 0.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords: fermentation scale-up, process optimization, recombinant protein expression, genetically modified microorganisms, biopharmaceuticals, Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, good manufacturing practices, yield improvement
MeSH terms: Culture Media, Escherichia coli, Fermentation, Glucose, Hydrogen-Ion Concentration, Oxygen, Peptones, Pichia, Recombinant Proteins, Saccharomyces cerevisiae, Biomass, Bioreactors, Feedback, Physiological

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