Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
Abstract
In this study we compare oxygen tension (Po 2) histograms measured with O 2 microelectrodes and a new optical Po 2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) ( n = 5–6). The transient response to glucose infusion or 100% O 2 breathing (hyperoxia) was also measured in tumors. Po 2 histograms of spleen and thymus with the two devices were not different. The OxyLite tumor Po 2 histogram, however, was left-shifted compared with the microelectrode (median Po 2 1.0 vs. 4.0 mmHg, P = 0.016). Both probes responded to acute hyperglycemia with a mean increase of 3–6 mmHg, but the microelectrode change was not significant. The OxyLite consistently recorded large Po 2 increases (∼28 mmHg) with hyperoxia, whereas the microelectrode response was variable. The OxyLite averages Po 2 over an area that contains interstitial and vascular components, whereas the microelectrode measures a more local Po 2. This study demonstrates the importance of considering the features of the measurement device when studying tissues with heterogeneous Po 2 distributions (e.g., tumors).
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Many tissues experience low PO2 levels even under normal physiologic conditions.
“it is noteworthy that many tissues experience low PO2 levels, even under normal physiologic conditions.”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [7]
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Self-citation
- Authors
- Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W.
- Affiliations
- Duke Medical Center (US)
- ORCID
- Dewhirst, Mark W.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- H2533-H2544
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1842875237
- Cited by
- 285
- References
- 40
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 14 · 2013: 18 · 2012: 19
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- tissue oxygen tension, tumor hypoxia, oxygen microelectrodes, spleen, thymus, hyperoxia, glucose infusion
- MeSH terms
- Adenocarcinoma, Administration, Inhalation, Animals, Female, Glucose, Infusions, Intravenous, Mammary Neoplasms, Experimental, Mice, Inbred DBA, Microelectrodes, Neoplasm Transplantation, Oxygen, Partial Pressure, Polarography, Rats, Inbred F344, Spleen, Thymus Gland, Reproducibility of Results, Cell Hypoxia, Mice, Rats
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