Tumor Hypoxia Imaging

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,069 · see citing works

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822 · see citing works

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., & Vaupel, P. W. (1996) · PubMed · Cited by 1,727 · see citing works

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674 · see citing works

Untitled work

(2000) · PubMed · Cited by 1,445 · see citing works

Untitled work

(1996) · PubMed · Cited by 1,188 · see citing works

Oncogenic alterations of metabolism

Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106 · see citing works

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

Ravi, R. K., Mookerjee, B., Bhujwalla, Z. M., Sutter, T. R., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · PubMed Central · Cited by 1,099 · see citing works

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967 · see citing works

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

Nordsmark, M., Overgaard, M., & Overgaard, J. (1996) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(96)91811-3 · Cited by 942 · see citing works

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876 · see citing works

Pitfalls in Oncologic Diagnosis with FDG PET Imaging: Physiologic and Benign Variants

SHREVE, P. D., Anzai, Y., & Wahl, R. L. (1999) · Radiographics · doi:10.1148/radiographics.19.1.g99ja0761 · Cited by 829 · see citing works

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

An, W. G., Kanekal, M., Simon, M. C., Maltepe, E., Blagosklonny, M. V., & Neckers, L. Μ. (1998) · Nature · doi:10.1038/32925 · Cited by 820 · see citing works

Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes

Flier, J. S., Mueckler, M., Usher, P., & Lodish, H. F. (1987) · Science · doi:10.1126/science.3103217 · Cited by 778 · see citing works

Glucose utilization of cerebral gliomas measured by [ 18 F] fluorodeoxyglucose and positron emission tomography

Chiro, G. D., DeLaPaz, R. L., Brooks, R. A., Sokoloff, L., Kornblith, P. L., Smith, B. H., Patronas, N. J., Kufta, C. V., KESSLER, R. M., Johnston, G. S., et al. (1982) · Neurology · doi:10.1212/wnl.32.12.1323 · Cited by 746 · see citing works

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients

Rasey, J. S., Koh, W.-J., Evans, M. L., Peterson, L. M., Lewellen, T. K., Graham, M. M., & Krohn, K. A. (1996) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00325-2 · Cited by 562 · see citing works

MRI of the tumor microenvironment

Gillies, R. J., Raghunand, N., Karczmar, G. S., & Bhujwalla, Z. M. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10181 · Cited by 553 · see citing works

Positron Emission Tomography Using [18F]Fluorodeoxyglucose for Monitoring Primary Chemotherapy in Breast Cancer

Schelling, M., Avril, N. E., Nährig, J., Kuhn, W. C., Römer, W., Sattler, D., Werner, M., Dose, J., Jänicke, F., Graeff, H., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.8.1689 · Cited by 521 · see citing works

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.

Loncaster, J. A., Harris, A. L., Davidson, S. E., Logue, J. P., Hunter, R. D., Wycoff, C. C., Pastorek, J., Ratcliffe, P. J., Stratford, I. J., & West, C. (2001) · PubMed · Cited by 482 · see citing works

Hypoxia and Glucose Metabolism in Malignant Tumors

Rajendran, J. G., Mankoff, D. A., O’Sullivan, F., Peterson, L. M., Schwartz, D. L., Conrad, E. U., Spence, A. M., Muzi, M., Farwell, D. G., & Krohn, K. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0688-3 · Cited by 389 · see citing works

Tumor Hypoxia Imaging with [F-18] Fluoromisonidazole Positron Emission Tomography in Head and Neck Cancer

Rajendran, J. G., Schwartz, D. L., OʼSullivan, J., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1773 · Cited by 355 · see citing works

Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.

Giatromanolaki, A. N., Koukourakis, M. I., Sivridis, E., Pastorek, J., Wykoff, C. C., Gatter, K. C., & Harris, A. L. (2001) · PubMed · Cited by 338 · see citing works

Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: Relationship to therapeutic response—a preliminary report

Dehdashti, F., Grigsby, P. W., Mintun, M. A., et al. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04477-2 · Cited by 326 · see citing works

[18F]FMISO and [18F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression

Rajendran, J. G., Wilson, D. C., Conrad, E. U., Peterson, L. M., Bruckner, J. D., Rasey, J. S., Chin, L. K., Hofstrand, P. D., Grierson, J. R., Eary, J. F., et al. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-1096-7 · Cited by 248 · see citing works

Comparative Measurements of Hypoxia in Human Brain Tumors Using Needle Electrodes and EF5 Binding

Evans, S. M., Judy, K. D., Dunphy, I., Jenkins, W. T., Nelson, P. T., Collins, R. A., Wileyto, E. P., Jenkins, K. W., Hahn, S. M., Stevens, C. W., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2424 · Cited by 216 · see citing works

Copper-64-diacetyl-bis( N 4 -methylthiosemicarbazone): An agent for radiotherapy

Lewis, J. S., Laforest, R. A., Buettner, T. L., Song, S., Fujibayashi, Y., Connett, J. M., & Welch, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1206 · Cited by 213 · see citing works

The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing

Kaelin, W. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.165 · Cited by 213 · see citing works

Involvement of Hypoxia-Inducible Factor 1 in Human Cancer.

Semenza, G. L. (2002) · Internal Medicine · doi:10.2169/internalmedicine.41.79 · Cited by 208 · see citing works

Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): Methodology and comparison with blood oxygen level‐dependent (BOLD) MRI

Elas, M., Williams, B. B., Parasca, A. D., Mailer, C., Pelizzari, C. A., Lewis, M. A., River, J. N., Karczmar, G. S., Barth, E. D., & Halpern, H. J. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10408 · Cited by 194 · see citing works

Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

Chapman, J. D., Baer, K. A., & Lee, J. H. (1983) · PubMed · Cited by 187 · see citing works

Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer

Lehtiö, K., Eskola, O., Viljanen, T., Oikonen, V., Grönroos, T. J., Sillanmäki, L. H., Grenman, R. A., & Minn, H. R. I. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.12.014 · Cited by 177 · see citing works

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(2003) · PubMed · Cited by 167 · see citing works

Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas

Nordsmark, M., Loncaster, J. A., Aquino‐Parsons, C., et al. (2003) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(03)00010-0 · Cited by 151 · see citing works

Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent Cu-diacetyl-bis(N 4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells

Obata, A., Yoshimi, E., Waki, A., et al. (2001) · Annals of Nuclear Medicine · doi:10.1007/bf02988502 · Cited by 137 · see citing works

The Presence of a Fibrotic Focus in Invasive Breast Carcinoma Correlates with the Expression of Carbonic Anhydrase IX and is a Marker of Hypoxia and Poor Prognosis

Colpaert, C., Vermeulen, P., Fox, S. B., Harris, A. L., Dirix, L. Y., & Marck, E. A. V. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1025702330207 · Cited by 132 · see citing works

Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

Cooper, R., Sarıoğlu, S., Sökmen, S., Füzün, M., Küpelioğlu, A., Valentine, H. R., Görken, İ. B., Airley, R. E., & West, C. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601202 · Cited by 113 · see citing works

Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry

Dubois, L. J., Landuyt, W., Haustermans, K. M., Dupont, P. J., Bormans, G. M., Vermaelen, P., Flamen, P., Verbeken, E. K., & Mortelmans, L. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602219 · Cited by 110 · see citing works

pO2 Polarography Versus Positron Emission Tomography ([18F] Fluoromisonidazole, [18F]-2-Fluoro-2’-Deoxyglucose)

Gagel, B., Reinartz, P., DiMartino, E., Zimny, M., Pinkawa, M., Maneschi, P., Stanzel, S. F., Hamacher, K., Coenen, H. H., Westhofen, M., et al. (2004) · Strahlentherapie und Onkologie · doi:10.1007/s00066-004-1229-y · Cited by 110 · see citing works

Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method

Gupta, A. K., Hutchinson, P. J., Fryer, T. D., et al. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.96.2.0263 · Cited by 100 · see citing works

Functional magnetic resonance imaging: A review of methodological aspects and clinical applications

Hennig, J., Speck, O., Koch, M. A., & Weiller, C. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10330 · Cited by 100 · see citing works

Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM

Burgman, P., O’Donoghue, J. A., Lewis, J. S., et al. (2005) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.05.003 · Cited by 98 · see citing works

Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside.

Urtasun, R. C., Parliament, M. B., McEwan, A. J. B., et al. (1996) · PubMed · Cited by 95 · see citing works

Non-Invasive PET and Spect Imaging of Tissue Hypoxia Using Isotopically Labeled 2-Nitroimidazoles

Koch, C. J., & Evans, S. M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0205-0_47 · Cited by 94 · see citing works

Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1.

Evans, S. M., Kachur, A. V., Shiue, C., Hustinx, R., Jenkins, W. T., Shive, G. G., Karp, J. S., Alavi, A., Lord, E. M., Dolbier, W. R., et al. (2000) · PubMed · Cited by 93 · see citing works

Iodine-124-labeled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning

ZANZONICO, P. B., O’Donoghue, J. A., Chapman, J. D., et al. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-003-1322-y · Cited by 92 · see citing works

Noninvasive Quantification of Regional Myocardial Metabolic Rate for Oxygen by Use of 15 O 2 Inhalation and Positron Emission Tomography

Iida, H., Rhodes, C. G., Araujo, L. I., et al. (1996) · Circulation · doi:10.1161/01.cir.94.4.792 · Cited by 91 · see citing works

Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection

Oliver, R., Woodwards, R. T. M., Sloan, P., Thakker, N., Stratford, I. J., & Airley, R. E. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2003.10.024 · Cited by 83 · see citing works

Near-infrared monitoring of cerebral tissue oxygen saturation and blood volume in newborn piglets

Brun, N. C., Møen, A., Børch, K., et al. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.2.h682 · Cited by 75 · see citing works

Feasibility of Detecting Hypoxia in Experimental Mouse Tumours with18F-fluorinated Tracers and Positron Emission Tomography: A Study Evaluating [18F]Fluoromisonidazole and [18F]Fluoro-2-deoxy-D-glucose

Bentzen, L. (2000) · Acta Oncologica · doi:10.1080/028418600750013320 · Cited by 67 · see citing works

Magnetic resonance imaging for in vivo assessment of tissue oxygen concentration

Krishna, M. C., SUBRAMANIAN, S., Kuppusamy, P., et al. (2001) · Seminars in Radiation Oncology · doi:10.1053/srao.2001.18104 · Cited by 64 · see citing works

Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation

Chapman, J. D., Schneider, R. F., Urbain, J.-L., et al. (2001) · Seminars in Radiation Oncology · doi:10.1053/srao.2001.18103 · Cited by 59 · see citing works

Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode Po2 measurements in murine tumors

Sørensen, M., Horsman, M. R., Cumming, P. D., et al. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.02.044 · Cited by 51 · see citing works

Dosimetry estimations for 123I-IAZA in healthy volunteers.

Stypinski, D., McQuarrie, S. A., Wiebe, L. I., et al. (2001) · PubMed · Cited by 18 · see citing works

A history of exploring cancer in context

Maman, S., & Witz, I. P. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0006-7 · Cited by 502 · see citing works

Hypoxia and the phenomenon of immune exclusion

Pietrobon, V., & Marincola, F. M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02667-4 · Cited by 119 · see citing works

Hypoxia Signaling in Cancer: From Basics to Clinical Practice

Sebestyén, A., Kopper, L., Dankó, T., & Tímár, J. (2021) · Pathology and Oncology Research · doi:10.3389/pore.2021.1609802 · Cited by 110 · see citing works

Characterization of the tumor microenvironment and tumor–stroma interaction by non-invasive preclinical imaging

Ramamonjisoa, N., & Ackerstaff, E. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00003 · Cited by 93 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works