AMPA receptor trafficking and synaptic plasticity: major unanswered questions.
Abstract
Dynamic movements of AMPA receptors in and out of the postsynaptic membrane account for, at least in part, the expression of NMDA receptor-dependent changes in synaptic efficacy such as long-term potentiation and long-term depression. Recently some of key molecules and subunit rules involved in AMPA receptor trafficking have been identified. In this update article, we try to highlight what we believe to be the major conceptual problems and unanswered questions in this rapidly moving field of neuroscience.
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NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).
“NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [10]
Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745 · see citing works
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655 · see citing works
Self-citationRegulation of AMPA receptor lateral movements
Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542 · see citing works
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Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
Sleep and synaptic homeostasis: a hypothesis
Tononi, G., & Cirelli, C. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.004 · Cited by 1,217 · see citing works
Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking
Hu, H., Real, E., Takamiya, K., Kang, M.-G., Ledoux, J., Huganir, R. L., & Malinow, R. (2007) · Cell · doi:10.1016/j.cell.2007.09.017 · Cited by 496 · see citing works
Man, H.-Y., Sekine-Aizawa, Y., & Huganir, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611698104 · Cited by 311 · see citing works
Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD
Han, K., Kim, M.-H., Seeburg, D., Seo, J., Verpelli, C., Han, S., Chung, H. S., Ko, J., Lee, H. W., Kim, K., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000187 · Cited by 71 · see citing works
Self-citationMolecular organization and assembly of the postsynaptic density of excitatory brain synapses.
Kim, E., & Ko, J. (2006) · Results and Problems in Cell Differentiation · doi:10.1007/400_011 · Cited by 11 · see citing works
- Authors
- Sheng, M., & Hyoung Lee, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sheng, Morgan
- ORCID
- Sheng, Morgan
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 46
- Issue
- 2
- Pages
- 127-134
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W2075298186
- Cited by
- 71
- References
- 7
- Citations by year
- 2020: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 35050, R01NS035050)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- AMPA receptor trafficking, synaptic plasticity, long-term potentiation, long-term depression, postsynaptic membrane, AMPA receptor subunit composition, synaptic efficacy
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synapses, Receptors, AMPA, Glutamic Acid, Protein Transport
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