Regulation of AMPA receptor lateral movements
Abstract
An essential feature in the modulation of the efficacy of synaptic transmission is rapid changes in the number of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors at post-synaptic sites on neurons. Regulation of receptor endo- and exocytosis has been shown to be involved in this process. Whether regulated lateral diffusion of receptors in the plasma membrane also participates in receptor exchange to and from post-synaptic sites remains unknown. We analysed the lateral mobility of native AMPA receptors containing the glutamate receptor subunit GluR2 in rat cultured hippocampal neurons, using single-particle tracking and video microscopy. Here we show that AMPA receptors alternate within seconds between rapid diffusive and stationary behaviour. During maturation of neurons, stationary periods increase in frequency and length, often in spatial correlation with synaptic sites. Raising intracellular calcium, a central element in synaptic plasticity, triggers rapid receptor immobilization and local accumulation on the neuronal surface. We suggest that calcium influx prevents AMPA receptors from diffusing, and that lateral receptor diffusion to and from synaptic sites acts in the rapid and controlled regulation of receptor numbers at synapses.
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Calcium elevations generally slow diffusion and locally accumulate AMPA receptors.
“Calcium elevations were shown to generally slow diffusion and locally accumulate AMPA receptors (Borgdorff and Choquet, 2002).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Borgdorff and Choquet, 2002
The respective contributions of lateral diffusion and activity-triggered exocytosis to synaptic plasticity remain unresolved.
“although their respective contributions have remained unresolved (Passafaro et al., 2001; Borgdorff and Choquet, 2002; Adesnik et al., 2005; Ashby et al., 2006; Park et al., 2006; Ehlers et al., 2007; Heine et al., 2008; Newpher and Ehlers, 2008; Yang et al., 2008; Kennedy et al., 2010; Opazo and Choquet, 2011; Czöndör et al., 2012; Czöndör and Thoumine, 2013).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Borgdorff and Choquet, 2002
Lateral diffusion of receptors through the plasma membrane and activity-triggered exocytosis of receptors from internal endosomal compartments are generally accepted regulation mechanisms for synaptic plasticity.
“Lateral diffusion of receptors through the plasma membrane and activity-triggered exocytosis of receptors from internal endosomal compartments have become generally accepted regulation mechanisms for synaptic plasticity, although their respective contributions have remained unresolved”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Borgdorff and Choquet, 2002
Many synaptic proteins are remarkably dynamic, including AMPARs, NMDARs, CaMKII, and scaffolding proteins such as PSD-95.
“These studies show that many synaptic proteins are remarkably dynamic, including AMPARs (237, 249, 327, 328), NMDARs (329), CaMKII (330), and scaffolding proteins, such as PSD-95 (331).”
From Synaptic memory and CaMKII (2023) · cites this paper as [327]
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Self-citation
- Authors
- Borgdorff, A. J., & Choquet, D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Choquet, Daniel
- ORCID
- Choquet, Daniel
- Venue
- Nature
- Published
- 2002-06
- Volume
- 417
- Issue
- 6889
- Pages
- 649-653
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1965202553
- Cited by
- 542
- References
- 29
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 15 · 2023: 13 · 2022: 12 · 2021: 26 · 2020: 17 · 2019: 27 · 2018: 25 · 2017: 15 · 2016: 18 · 2015: 19 · 2014: 23 · 2013: 32 · 2012: 28
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- AMPA receptors, GluR2, receptor lateral diffusion, synaptic plasticity, intracellular calcium, receptor immobilization, synaptic transmission, hippocampal neurons, single-particle tracking
- MeSH terms
- Animals, Calcium, Cell Differentiation, Cells, Cultured, Diffusion, Hippocampus, Kinetics, Neurons, Photolysis, Synapses, Receptors, AMPA, Microscopy, Video, Protein Subunits, Protein Transport, Rats
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