Progress in monitoring, modeling and control of bioprocesses during the last 20 years
Abstract
The paper gives a review on the recent development of bioprocess engineering. It includes monitoring of product formation processes by flow injection analysis, various types of chromatographic and spectroscopic methods as well as by biosensors. The evaluation of mycelial morphology and physiology by digital image analysis is discussed also. It deals with advanced control of indirectly evaluated process variables by means of state estimation/observer, with the use of structured and hybrid models, expert systems and pattern recognition for process optimization and gives a short report on the state of the art of metabolic flux analysis and metabolic engineering.
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Online monitoring and closer process control of bioreactors is a basic requirement for the development of efficient biological processes.
“Therefore, online monitoring and closer process control of bioreactors is a basic requirement for the development of efficient biological processes (Marose et al., 1999; Schügerl, 2001).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Schügerl, 2001
NADH fluorescence intensity signal has a good correlation with biomass concentration and its metabolic state.
“NADH is a highly fluorescent molecule, and it is known that the fluorescence intensity signal has a good correlation with the biomass concentration and its metabolic state (Tartakovsky et al., 1996; Marose et al., 1999; Schügerl, 2001; Pons et al., 2004).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Schügerl, 2001
Cites
Two-Dimensional Fluorescence Spectroscopy: A New Tool for On-Line Bioprocess Monitoring
Marose, S., Lindemann, C., & Scheper, T. (1998) · Biotechnology Progress · doi:10.1021/bp970124o · Cited by 190 · see citing works
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Bioreactor monitoring with spectroscopy and chemometrics: a review
Lourenço, N. D., Lopes, J. A., Almeida, C. F., Sarraguça, M. C., & Pinheiro, H. M. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6073-9 · Cited by 275 · see citing works
Wu, Z., & Shi, X. (2007) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.02038.x · Cited by 115 · see citing works
Bioreactor state estimation and control
Komives, C., & Parker, R. S. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.09.001 · Cited by 74 · see citing works
Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry
Sá, M., Ferrer‐Ledo, N., Gao, F., Bertinetto, C. G., Jansen, J., Crespo, J. G., Wijffels, R. H., Barbosa, M., & Galinha, C. F. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14013 · Cited by 29 · see citing works
“…of the mathematics needed for spectra interpretation A full fluorescence spectrum contains not only complex in-depth information about the natural fluorophores present in the sample but also the interferences between them and the environmental medium (Marose et al., 1999; Sch€ugerl, 2001).”
BackgroundInfluentialThe Kalman Filter for the Supervision of Cultivation Processes
Yousefi-Darani, A., Paquet-Durand, O., & Hitzmann, B. (2020) · Advances in Biochemical Engineering/Biotechnology · doi:10.1007/10_2020_145 · Cited by 15 · see citing works
- Authors
- Schügerl, K.
- Affiliations
- Leibniz University Hannover (DE)
- Corresponding author
- Schügerl, Karl
- Venue
- Journal of Biotechnology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 85
- Issue
- 2
- Pages
- 149-173
- ISSN
- 0168-1656 (ISSN-L)
- OpenAlex
- W2035897404
- Cited by
- 278
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 13 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 21
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Control and Systems Engineering › Fault Detection and Control Systems
- Physical Sciences › Engineering › Biomedical Engineering › Fluid Dynamics and Mixing
- Keywords
- bioprocess monitoring, bioprocess control, flow injection analysis, chromatography, spectroscopy, biosensors, mycelial morphology, digital image analysis, state estimation, observer, structured models, hybrid model, expert systems, pattern recognition, process optimization, metabolic flux analysis, metabolic engineering
- MeSH terms
- Biotechnology, Chromatography, Expert Systems, Metabolism, Models, Biological, Pattern Recognition, Automated, Spectrum Analysis, Biosensing Techniques, Flow Injection Analysis, History, 20th Century
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