Assessing the potential for α-glucosidase inhibitors in prediabetic states

Holman, Rury R

doi:10.1016/s0168-8227(98)00038-2

Cited by 197Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Assessing the potential for α-glucosidase inhibitors in prediabetic states

Holman, Rury R·1998·Diabetes Research and Clinical Practice

DOI 10.1016/s0168-8227(98)00038-2

Open this paper in CoChat — free account

Abstract

Type 2 diabetes often has an insidious onset with hyperglycaemia being present for many years before diagnosis is made. It is a progressive disease, due in part to loss of beta-cell function, with the reduction in function probably commencing 10-12 years prior to diagnosis and being aggravated by increasing fasting plasma glucose levels. Earlier intervention in those at risk from type 2 diabetes, aimed at minimizing hyperglycaemia, may prevent or delay overt diabetes and the associated development of micro- and macrovascular disease. Six-year follow-up data from the UK Prospective Diabetes Study, confirm that sulphonylurea, metformin and insulin therapy can reduce hyperglycaemia in individuals with type 2 diabetes. Although none of these agents prevent the subsequent progressive increase in fasting glucose levels, preliminary results with acarbose show that fasting plasma glucose levels can be maintained over 1 year of therapy. Three large-scale studies are currently investigating whether treatment with acarbose at an earlier stage of the disease process, in subjects with varying degrees of glucose intolerance, may be beneficial in helping to prevent or delay the onset of diabetes.

Integrity signals

Registry

Crossref · 10.1016/s0168-8227(98)00038-2

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In the UKPDS cohort of subjects with recently diagnosed Type 2 diabetes, there is an ongoing decline in beta-cell function without a change in insulin sensitivity.
“in this cohort of subjects with recently diagnosed Type 2 diabetes, an ongoing decline in beta-cell function without a change in insulin sensitivity was occurring [17, 18].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [18]
Data from the UKPDS suggest that beta-cell dysfunction commences years before hyperglycaemia develops.
“Data from the UKPDS strongly suggest that beta-cell dysfunction commences years before hyperglycaemia develops [18].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [18]
Based on the UKPDS and the longitudinal assessment in Pima Indians, the major reason for the decline in glucose tolerance seems to be a progressive loss of beta-cell function.
“Based on the UKPDS [18] and the longitudinal assessment in Pima Indians [95], the major reason for the decline in glucose tolerance seems to be a progressive loss of beta-cell function.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [18]

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease
U.K. Prospective Diabetes Study Group (1995) · Diabetes · doi:10.2337/diab.44.11.1249 · Cited by 1,923 · see citing works
Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise The 6-year Malm� feasibility study
Eriksson, K. F., & Lindg�rde, F. (1991) · Diabetologia · doi:10.1007/bf00400196 · Cited by 1,092 · see citing works
U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group
(1995) · Diabetes · doi:10.2337/diabetes.44.11.1249 · Cited by 796 · see citing works
CORONARY-HEART-DISEASE RISK AND IMPAIRED GLUCOSE TOLERANCE The Whitehall Study
Fuller, J., Shipley, M., Rose, G., Jarrett, R. J., & Keen, H. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92651-3 · Cited by 782 · see citing works
UK prospective diabetes study (UKPDS)
UK Prospective Diabetes Study Group (1991) · Diabetologia · doi:10.1007/bf00400195 · Cited by 565 · see citing works
The Bedford Survey: Ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics
Jarrett, R. J., McCartney, P., & KEEN, H. (1982) · Diabetologia · doi:10.1007/bf00254833 · Cited by 436 · see citing works
The Efficacy of Acarbose in the Treatment of Patients with Non–Insulin-Dependent Diabetes Mellitus: A Multicenter, Controlled Clinical Trial
Chiasson, J., Josse, R. G., Hunt, J. A., Palmason, C., Rodger, N. W., Ross, S. A., Ryan, E. A., Tan, M. H., & Wolever*, T. M. S. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00004 · Cited by 433 · see citing works
Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels. The Paris Prospective Study, ten years later.
Eschwège, É., Richard, J. L., Thibult, N., Ducimetière, P., Warnet, J., Claude, J., & Rosselin, G. (1985) · PubMed · Cited by 311 · see citing works
The ten-year follow-up of the Bedford Survey (1962?1972): Glucose tolerance and diabetes
KEEN, H., Jarrett, R. J., & McCartney, P. (1982) · Diabetologia · doi:10.1007/bf00254832 · Cited by 287 · see citing works
Ten-year Follow-up of Subjects with Impaired Glucose Tolerance: Prevention of Diabetes by Tolbutamide and Diet Regulation
Sartor, G., Scherstén, B., Carlström, S., Melander, A., Nordén, Å., & Persson, G. (1980) · Diabetes · doi:10.2337/diab.29.1.41 · Cited by 285 · see citing works
Predictive value of Glasgow coma score for awakening after out-of-hospital cardiac arrest. Cerebral Resuscitation Study Group of the Belgian Society for Intensive Care.
Mullie, A., Verstringe, P., Buylaert, W. A., Houbrechts, H., Michem, N., Delooz, H. H., Verbruggen, H. W., den Broeck, L. V., Corne, L., & Lauwaert, D. (1988) · PubMed · Cited by 257 · see citing works
The Effect of Acarbose on Insulin Sensitivity in Subjects With Impaired Glucose Tolerance
Chiasson, J., Josse, R. G., Leiter, L. A., Mihic, M., Nathan, D. M., Palmason, C., Cohen, R. M., & Wolever, T. M. S. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1190 · Cited by 168 · see citing works
The Placenta as a Glucocorticoid Target Tissue: Exchange Assay of (3H)-Dexamethasone Binding and Effect of Steroids on Receptor Content
Heller, C. L., Coirini, H., & Nicola, A. F. D. (1983) · Hormone and Metabolic Research · doi:10.1055/s-2007-1018622 · Cited by 108 · see citing works
The Whitehall Study: Ten Year Follow‐up Report on Men With Impaired Glucose Tolerance With Reference to Worsening to Diabetes and Predictors of Death
Jarrett, R. J., Keen, H., & McCartney, P. (1984) · Diabetic Medicine · doi:10.1111/j.1464-5491.1984.tb01973.x · Cited by 96 · see citing works
Impaired Glucose Tolerance and NIDDM: Does a Lifestyle Intervention Program Have an Effect?
Bourn, D. M., Mann, J. I., McSkimming, B. J., Waldron, M., & Wishart, J. D. (1994) · Diabetes Care · doi:10.2337/diacare.17.11.1311 · Cited by 87 · see citing works
Ten-year follow-up of subjects with impaired glucose tolerance: prevention of diabetes by tolbutamide and diet regulation
Sartor, G., Scherstén, B., Carlström, S., et al. (1980) · Diabetes · doi:10.2337/diabetes.29.1.41 · Cited by 87 · see citing works
The fasting hyperglycaemia study: II. Randomized controlled trial of reinforced healthy-living advice in subjects with increased but not diabetic fasting plasma glucose
Dyson, P. A., Hammersley, M. S., Morris, R. J., Holman, R. R., & Turner, R. C. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90318-8 · Cited by 66 · see citing works
Self-citation
[Effect of dietary and/or exercise intervention on incidence of diabetes in 530 subjects with impaired glucose tolerance from 1986-1992].
Pan, X., Li, G., & Hu, Y. (1995) · PubMed · Cited by 24 · see citing works
The effect of acarbose on insulin sensitivity in subjects with impaired glucose tolerance.
Jl, C. (1996) · PubMed · Cited by 15 · see citing works
Glycaemic improvement over one year in a double-blind trial of acarbose in 1,946 NIDDM patients
Holman, R. R., Cull, C. A., & Turner, R. C. (1996) · Diabetologia · Cited by 10 · see citing works
Self-citation
Early Diabetes Intervention Trial
Holman, R. R. (2012) · doi:10.1186/isrctn96631607 · Cited by 5 · see citing works
Self-citation

Flagged first, then by citations

2 of the 24 references couldn’t be matched to a known paper.

Sorted by citations

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166 · see citing works
β-Cell Failure in Diabetes and Preservation by Clinical Treatment
WAJCHENBERG, B. L. (2007) · Endocrine Reviews · doi:10.1210/10.1210/er.2006-0038 · Cited by 716 · see citing works
The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes
Kahn, S. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7713 · Cited by 694 · see citing works
Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.
Fu, Z., Gilbert, E. R., & Liu, D. (2013) · PubMed · Cited by 600 · see citing works
Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Chen, C., Cohrs, C. M., Stertmann, J., Bozsak, R., & Speier, S. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.019 · Cited by 491 · see citing works
Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes
Gough, S. C. L., Bode, B. W., Woo, V. C., Rodbard, H. W., Linjawi, S., Poulsen, P., Damgaard, L. H., & Buse, J. B. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70174-3 · Cited by 367 · see citing works
beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.
Porte, D., & Kahn, S. E. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s160 · Cited by 332 · see citing works
The Natural Course of β-Cell Function in Nondiabetic and Diabetic Individuals
Festa, A., Williams, K., D’Agostino, R., Wagenknecht, L. E., & Haffner, S. M. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1100 · Cited by 267 · see citing works
Is There a Role for ??-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?
Scheen, A. J. (2003) · Drugs · doi:10.2165/00003495-200363100-00002 · Cited by 242 · see citing works
β-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities
LeRoith, D. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01276-7 · Cited by 235 · see citing works
Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations
Chen, T., Ni, Y., Ma, X., Bao, Y., Liu, J., Huang, F., Hu, C., Xie, G., Zhao, A., Jia, W., et al. (2016) · Scientific Reports · doi:10.1038/srep20594 · Cited by 198 · see citing works
Beta-cell failure in type 2 diabetes: mechanisms, markers, and clinical implications
Wysham, C., & Shubrook, J. (2020) · Postgraduate Medicine · doi:10.1080/00325481.2020.1771047 · Cited by 193 · see citing works
Youth Type 2 Diabetes
Gungor, N., Bacha, F., Saad, R., Janosky, J., & Arslanian, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.638 · Cited by 186 · see citing works
Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis
Cohrs, C. M., Panzer, J. K., Drotar, D. M., Enos, S. J., Kipke, N., Chen, C., Bozsak, R., Schöniger, E., Ehehalt, F., Distler, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.033 · Cited by 154 · see citing works
The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass
Aron‐Wisnewsky, J., Sokolovska, N., Liu, Y., Comaneshter, D. S., Vinker, S., Pecht, T., Poitou, C., Oppert, J., Bouillot, J., Genser, L., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4371-7 · Cited by 143 · see citing works
β-Cell Dysfunction in Subjects With Impaired Glucose Tolerance and Early Type 2 Diabetes
Festa, A., Williams, K., Hanley, A. J., & Haffner, S. M. (2008) · Diabetes · doi:10.2337/db07-0954 · Cited by 127 · see citing works
Prevention and treatment of type 2 diabetes: Current role of lifestyle, natural product, and pharmacological interventions
Hays, N. P., Galassetti, P. R., & Coker, R. H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.003 · Cited by 122 · see citing works
Type 2 Diabetes Mellitus in Youth: The Complete Picture to Date
Gungor, N., Hannon, T. S., Libman, I. M., Bacha, F. F., & Arslanian, S. A. (2005) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2005.07.009 · Cited by 115 · see citing works
Tryptophan Predicts the Risk for Future Type 2 Diabetes
Chen, T., Zheng, X., Ma, X., Bao, Y., Ni, Y., Hu, C., Rajani, C., Huang, F., Zhao, A., Jia, W., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162192 · Cited by 113 · see citing works
When basal insulin therapy in type 2 diabetes mellitus is not enough—what next?
Raccah, D., Bretzel, R. G., Owens, D. R., & Riddle, M. C. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.733 · Cited by 111 · see citing works
Safety and efficacy of insulin degludec/liraglutide ( ID egLira) added to sulphonylurea alone or to sulphonylurea and metformin in insulin‐naïve people with Type 2 diabetes: the DUAL IV trial
Rodbard, H. W., Bode, B. W., Harris, S. B., Rose, L., Lehmann, L., Jarlov, H., Thurman, J., & the Dual Action of Liraglutide and insulin degludec (DUAL) IV trial investigators (2016) · Diabetic Medicine · doi:10.1111/dme.13256 · Cited by 108 · see citing works
Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus
Leahy, J. L., Hirsch, I. B., PETERSON, K. A., & Schneider, D. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0668 · Cited by 108 · see citing works
Diagnosis, epidemiology and pathogenesis of diabetes mellitus: An update for psychiatrists
Holt, R. I. G. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.47.s55 · Cited by 107 · see citing works
Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications
Jankauskas, S. S., Gambardella, J., Sardu, C., Lombardi, A., & Santulli, G. (2021) · Non-Coding RNA · doi:10.3390/ncrna7030039 · Cited by 103 · see citing works
Anti-α-glucosidase activity of Chinese traditionally fermented soybean (douchi)
Chen, J., Cheng, Y., Yamaki, K., & Li-te, L. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.10.003 · Cited by 95 · see citing works
Progressive beta cell failure in type 2 diabetes mellitus of youth
Gungor, N., & Arslanian, S. A. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.12.045 · Cited by 90 · see citing works
Effect of sitagliptin, a dipeptidyl peptidase‐4 inhibitor, on beta‐cell function in patients with type 2 diabetes: a model‐based approach
Xu, L., Man, C. D., Charbonnel, B. H., Meninger, G., Davies, M. J., Williams‐Herman, D., Cobelli, C., & Stein, P. P. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00887.x · Cited by 88 · see citing works
Association between antipsychotic drugs and diabetes
Holt, R. I. G., & Peveler, R. (2005) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00495.x · Cited by 73 · see citing works
Emerging treatment options for type 2 diabetes
Piya, M. K., Tahrani, A. A., & Barnett, A. H. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03711.x · Cited by 73 · see citing works
β- and α-Cell Dysfunction in Subjects Developing Impaired Glucose Tolerance
Åhrén, B. (2008) · Diabetes · doi:10.2337/db08-1158 · Cited by 68 · see citing works
Glucose challenge test screening for prediabetes and undiagnosed diabetes
Phillips, L. S., Ziemer, D. C., Kolm, P., Weintraub, W. S., Vaccarino, V., Rhee, M. K., Chatterjee, R., Narayan, K. M. V., & Koch, D. D. (2009) · Diabetologia · doi:10.1007/s00125-009-1407-7 · Cited by 67 · see citing works
Current barriers to initiating insulin therapy in individuals with type 2 diabetes
Sanz-Pastor, A. G., Enríquez, A. J., Bao, A. S., & Ampudia‐Blasco, F. J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1366368 · Cited by 66 · see citing works
Clinical Features, Diagnostic Criteria and Pathogenesis of Diabetes Mellitus
Imam, K. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5441-0_25 · Cited by 64 · see citing works
The β Cell in Diabetes: Integrating Biomarkers With Functional Measures
Kahn, S. E., Chen, Y., Esser, N., Taylor, A. J., van Raalte, D. H., Zraika, S., & Verchere, C. B. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab021 · Cited by 69 · see citing works
β-cell neogenesis: A rising star to rescue diabetes mellitus
Niu, F., Liu, W., Ren, Y., Tian, Y., Shi, W., Li, M., Li, Y., Xiong, Y., & Lü, Q. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.10.008 · Cited by 65 · see citing works
Evaluation of the hypoglycemic effect of probiotics via directly consuming glucose in intestines of STZ-induced diabetic mice and glucose water-induced diabetic mice
Wang, L., Shang, Q., Guo, W., Wu, X., Wu, L., Wu, L., & Chen, T. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103614 · Cited by 58 · see citing works
Preventing Type II Diabetes Mellitus
Prisant, L. M. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004263018 · Cited by 58 · see citing works
Short‐term intensified insulin treatment in type 2 diabetes: long‐term effects on β‐cell function
Retnakaran, R. R., & Zinman, B. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01658.x · Cited by 56 · see citing works
Dapagliflozin for the treatment of type 2 diabetes: a review of the literature
Narendran, P., & Saeed, M. A. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s50963 · Cited by 54 · see citing works
Cost and policy implications from the increasing prevalence of obesity and diabetes mellitus
Ryan, J. (2009) · Gender Medicine · doi:10.1016/j.genm.2009.01.002 · Cited by 51 · see citing works
Combination therapy with rosiglitazone and glibenclamide compared with upward titration of glibenclamide alone in patients with type 2 diabetes mellitus
Kerényi, Z., Samer, H., James, R., Yan, Y., & Stewart, M. W. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.09.009 · Cited by 52 · see citing works
Terpenoids as potential phytoconstituent in the treatment of diabetes: From preclinical to clinical advancement.
Roy, S., Ghosh, A., Majie, A., Karmakar, V., Das, S., Dinda, S. C., Bose, A., & Gorain, B. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155638 · Cited by 48 · see citing works
Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies
Meece, J. D. (2007) · Current Medical Research and Opinion · doi:10.1185/030079906x167336 · Cited by 49 · see citing works
Comparison of Acarbose and Gliclazide as First-line Agents in Patients with Type 2 Diabetes
Salman, S., Salman, F., Satman, İ., Yılmaz, Y., Özer, E., Şengül, A. M., Demirel, H. Ö., Karşıdağ, K., Dınççağ, N., & Yilmaz, M. T. (2001) · Current Medical Research and Opinion · doi:10.1185/030079901750120231 · Cited by 45 · see citing works
Effects of meal and incretins in the regulation of splanchnic blood flow
Koffert, J., Honka, H., Teuho, J., Kauhanen, S. P., Hurme, S. A. M., Parkkola, R. K., Oikonen, V., Mari, A., Lindqvist, A., Wierup, N., et al. (2017) · Endocrine Connections · doi:10.1530/ec-17-0015 · Cited by 45 · see citing works
The Role of Thiazolidinediones in the Treatment of Patients with Type 2 Diabetes Mellitus
Mooradian, A. D., Chehade, J. M., & Thurman, J. E. (2002) · Treatments in Endocrinology · doi:10.2165/00024677-200201010-00002 · Cited by 45 · see citing works
β‐cell preservation: a potential role for thiazolidinediones to improve clinical care in Type 2 diabetes
Leiter, L. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01605.x · Cited by 44 · see citing works
Patient empowerment and optimal glycemic control
White, R. D. (2012) · Current Medical Research and Opinion · doi:10.1185/03007995.2012.677417 · Cited by 41 · see citing works
Effect of folic acid supplementation on risk of new‐onset diabetes in adults with hypertension in China: Findings from the China Stroke Primary Prevention Trial (CSPPT)
Qin, X., Li, J., Zhang, Y., Chen, D., Wang, B., He, M., Fu, J., Tang, G., Cai, Y., Shi, X., et al. (2015) · Journal of Diabetes · doi:10.1111/1753-0407.12346 · Cited by 41 · see citing works
Estimating the Long-Term Cost-Effectiveness of Exenatide in the United States: An Adjunctive Treatment for Type 2 Diabetes Mellitus
Minshall, M. E., Oglesby, A. K., Wintle, M. E., Valentine, W. J., Roze, S., & Palmer, A. J. (2007) · Value in Health · doi:10.1111/j.1524-4733.2007.00211.x · Cited by 40 · see citing works
Impact of Sitagliptin on Markers of β-cell Function: A Meta-Analysis
Riche, D. M., East, H. E., & Riche, K. D. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31818eb721 · Cited by 40 · see citing works
β‐Cell mass plasticity in type 2 diabetes
Prato, S. D., Wishner, W. J., Gromada, J., & Schluchter, B. J. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00360.x · Cited by 39 · see citing works
Clinical Approaches to Preserve β-Cell Function in Diabetes
WAJCHENBERG, B. L. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_23 · Cited by 38 · see citing works
Impact of the new WHO classification and diagnostic criteria
Bennett, P. H. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.0010s2001.x · Cited by 38 · see citing works
Initiating Insulin Therapy in Type 2 Diabetic Patients Failing on Oral Hypoglycemic Agents
Bretzel, R. G., Eckhard, M., Landgraf, W., Owens, D. R., & Linn, T. (2009) · Diabetes Care · doi:10.2337/dc09-s319 · Cited by 36 · see citing works
Long-term High-fat High-sucrose Diet Promotes Enlarged Islets and β-Cell Damage by Oxidative Stress in Bama Minipigs
Zhao, Z.-Z., Xin, L., Xia, J., Yang, S., Chen, Y.-X., & Li, K. (2015) · Pancreas · doi:10.1097/mpa.0000000000000349 · Cited by 36 · see citing works
Use of insulin in type 2 diabetes: What we learned from recent clinical trials on the benefits of early insulin initiation
Markolf Hanefeld, E. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.08.006 · Cited by 35 · see citing works
Detecting people at high risk of type 2 diabetes- How do we find them and who should be treated?
Kong, A. P. S., Luk, A. O. Y., & Chan, J. C. N. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.06.003 · Cited by 32 · see citing works
Dietary restriction preserves the mass and function of pancreatic β cells via cell kinetic regulation and suppression of oxidative/ER stress in diabetic mice
Kanda, Y., Hashiramoto, M., Shimoda, M., Hamamoto, S., Tawaramoto, K., Kimura, T., Hirukawa, H., Nakashima, K., & Kaku, K. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.007 · Cited by 32 · see citing works
Two flavanone compounds from litchi (Litchi chinensis Sonn.) seeds, one previously unreported, and appraisal of their α-glucosidase inhibitory activities
Ren, S., Xu, D., Pan, Z., Gao, Y., Jiang, Z., & Gao, Q. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.02.054 · Cited by 32 · see citing works
The natural history of diabetes‐related complications: the UKPDS experience
Matthews, D. R. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.0010s2007.x · Cited by 32 · see citing works
Early Insulin: An Important Therapeutic Strategy
DAILEY, G. E. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.220 · Cited by 32 · see citing works
Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat
Lim, K. H., Han, J.-H., Lee, J. Y., Park, Y. S., Cho, Y. S., Kang, K., Yuk, W.-J., Hwang, K. Y., Seong, S., Kim, B., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.08.036 · Cited by 31 · see citing works
Postprandial C‐peptide to glucose ratio as a predictor of β‐cell function and its usefulness for staged management of type 2 diabetes
Lee, E. Y., Hwang, S., Lee, S., Lee, Y.-H., Choi, R. A., Lee, Y., Lee, B.-W., Kang, E., Ahn, C., Cha, B., et al. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12187 · Cited by 33 · see citing works
A practical approach to the clinical challenges in initiation of basal insulin therapy in people with type 2 diabetes
Forst, T. M., Choudhary, P., Schneider, D., Linetzky, B., & Pozzilli, P. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3418 · Cited by 31 · see citing works
Management of type 2 diabetes: the role of incretin mimetics
Stonehouse, A. H., Holcombe, J. H., & Kendall, D. M. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.15.2095 · Cited by 29 · see citing works
Comparison of Crataegus pinnatifida Bunge var. typica Schneider and C. pinnatifida Bunge fruits for antioxidant, anti-α-glucosidase, and anti-inflammatory activities
Li, C., Son, H. J., Huang, C., Lee, S. K., Lohakare, J., & Wang, M. (2010) · Food Science and Biotechnology · doi:10.1007/s10068-010-0108-9 · Cited by 29 · see citing works
Current trend in drug delivery considerations for subcutaneous insulin depots to treat diabetes
Jayakrishnapillai, P. V., Nair, S. V., & Kamalasanan, K. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.02.017 · Cited by 28 · see citing works
An indirect treatment comparison of the efficacy of insulin degludec/liraglutide (IDegLira) and insulin glargine/lixisenatide (iGlarLixi) in patients with type 2 diabetes uncontrolled on basal insulin
Evans, M., Billings, L. K., Håkan‐Bloch, J., Slothuus, U., Abrahamsen, T. J., Andersen, A., & Jansen, J. P. (2017) · Journal of Medical Economics · doi:10.1080/13696998.2017.1409228 · Cited by 28 · see citing works
In support of an early polypharmacy approach to the treatment of type 2 diabetes
Wright, E. E., Stonehouse, A. H., & Cuddihy, R. M. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01255.x · Cited by 27 · see citing works
Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register
Kong, A. P. S., Lew, T., Lau, E. S. H., Lim, L., Kesavadev, J., Jia, W., Sheu, W. H., Sobrepeña, L., Tan, A. T. B., Nguyen, T. K., et al. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13950 · Cited by 27 · see citing works
In vitro and in vivo anti-hyperglycemic effects of green and red mustard leaves (Brassica juncea var. integrifolia)
Jo, S., Cho, C.-Y., Ha, K., Lee, J., Choi, H., Kwon, Y., & Apostolidis, E. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12583 · Cited by 27 · see citing works
Switching from NPH insulin to once-daily insulin detemir in basal-bolus-treated patients with diabetes mellitus: data from the European cohort of the PREDICTIVE™ study
Sreenan, S., Virkamäki, A., Zhang, K., Hansen, J. B., & on behalf of the PREDICTIVE™ study group (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01939.x · Cited by 26 · see citing works
Further investigation of the psychometric properties of the insulin treatment appraisal scale among insulin-using and non-insulin-using adults with type 2 diabetes: results from diabetes MILES – Australia
Holmes‐Truscott, E., Pouwer, F., & Speight, J. (2014) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-12-87 · Cited by 25 · see citing works
Buccal spray insulin in subjects with impaired glucose tolerance: the prevoral study
Palermo, A., Napoli, N., Manfrini, S., Lauria, A., Strollo, R., & Pozzilli, P. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01312.x · Cited by 23 · see citing works
Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in Malaysian Patients With Type 2 Diabetes Mellitus Without Prior Known Cardiovascular Disease
Chee, K. H., Tan, K. L., Ibrahim, L., Saiful, S. S., Chew, Y. Y., Chinna, K., & Tan, A. T. B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.676862 · Cited by 22 · see citing works
Carotid body: an emerging target for cardiometabolic co‐morbidities
Thakkar, P. C., Pauža, A. G., Murphy, D., & Paton, J. F. R. (2023) · Experimental Physiology · doi:10.1113/ep090090 · Cited by 22 · see citing works
Beta-cell function and mass in type 2 diabetes.
Larsen, M. O. (2009) · PubMed · Cited by 22 · see citing works
Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: How markers of β-cell loss may assist
Neutzsky-Wulff, A. V., Andreassen, K. V., Hjuler, S. T., Feigh, M., Bay‐Jensen, A., Zheng, Q., Henriksen, K., & Karsdal, M. A. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-214 · Cited by 21 · see citing works
The reduction effect of low molecular weight chitosan oligosaccharide (GO2KA1) on postprandial blood glucose levels in healthy individuals
Jo, S., Ha, K., Lee, J., Kim, Y., Apostolidis, E., & Kwon, Y. (2014) · Food Science and Biotechnology · doi:10.1007/s10068-014-0131-3 · Cited by 20 · see citing works
Relationship of MTHFR Gene 677C→T Polymorphism, Homocysteine, and Estimated Glomerular Filtration Rate Levels With the Risk of New-Onset Diabetes
Qin, X., Li, Y., Yuan, H., Xie, D., Tang, G., Wang, B., Wang, X., Xu, X. P., Xu, X., & Hou, F. F. (2015) · Medicine · doi:10.1097/md.0000000000000563 · Cited by 20 · see citing works
Liraglutide effects on beta‐cell, insulin sensitivity and glucose effectiveness in patients with stable coronary artery disease and newly diagnosed type 2 diabetes
Anholm, C., Kumarathurai, P., Pedersen, L., Nielsen, O., Kristiansen, O. P., Fenger, M., Madsbad, S., Sajadieh, A., & Haugaard, S. (2017) · Diabetes, obesity and metabolism · doi:10.1111/dom.12891 · Cited by 18 · see citing works
Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort
Rasouli, N., Younes, N., Utzschneider, K. M., Inzucchi, S. E., Balasubramanyam, A., Cherrington, A., Ismail‐Beigi, F., Cohen, R. M., Olson, D. E., DeFronzo, R. A., et al. (2020) · Diabetes Care · doi:10.2337/dc20-1787 · Cited by 20 · see citing works
Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases
Mosa, R., Zhang, Z., Shao, R., Deng, C., Chen, J., & Chen, C. (2015) · Endocrine · doi:10.1007/s12020-015-0531-z · Cited by 20 · see citing works
Impact of Lifestyle Behaviors on Postprandial Hyperglycemia during Continuous Glucose Monitoring in Adult Males with Overweight/Obesity but without Diabetes
Kishimoto, I., & Ohashi, A. (2021) · Nutrients · doi:10.3390/nu13093092 · Cited by 19 · see citing works
A 74-Year-Old Woman With Diabetes
Abrahamson, M. J. (2007) · JAMA · doi:10.1001/jama.297.2.196 · Cited by 19 · see citing works
Willingness to initiate insulin among adults with type 2 diabetes in Australian primary care: Results from the Stepping Up Study
Holmes‐Truscott, E., Blackberry, I., O'Neal, D. N., Furler, J., & Speight, J. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.12.011 · Cited by 19 · see citing works
Delayed insulin secretion response during an OGTT is associated with an increased risk for incidence of diabetes in NGT subjects
Sun, Y. W., Han, J., Lin, Z., Song, L., Wang, C., & Jia, W. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.07.029 · Cited by 19 · see citing works
Targeting Insulin Resistance and β-Cell Dysfunction: The Role of Thiazolidinediones
Prato, S. D., & Marchetti, P. (2004) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2004.6.719 · Cited by 19 · see citing works
Choice of early treatment regimen and impact on β-cell preservation in type 2 diabetes
Mudaliar, S. R. D. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12154 · Cited by 18 · see citing works
Immunoaffinity Capillary Electrophoresis in the Era of Proteoforms, Liquid Biopsy and Preventive Medicine: A Potential Impact in the Diagnosis and Monitoring of Disease Progression
Guzman, N., & Guzman, D. E. (2021) · Biomolecules · doi:10.3390/biom11101443 · Cited by 17 · see citing works
Synthesis, in vitro α-glucosidase inhibitory activity and molecular dynamics simulation of some new coumarin-fused 4H-pyran derivatives as potential anti-diabetic agents
Ghorbani, H., Ebadi, A., Faramarzi, M. A., Mojtabavi, S., Mahdavi, M. R., & Najafi, Z. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.135349 · Cited by 17 · see citing works
Flavonoids from litchi(Litchi chinensis Sonn.) seeds and their inhibitory activities on α-glucosidase
Ren, S., Xu, D., Gao, Y., Ma, Y.-T., & Gao, Q. (2013) · Chemical Research in Chinese Universities · doi:10.1007/s40242-013-3030-x · Cited by 17 · see citing works
High Glucose Predisposes Gene Expression and ERK Phosphorylation to Apoptosis and Impaired Glucose-Stimulated Insulin Secretion via the Cytoskeleton
Yeo, R. W. Y., Yang, K., Li, G., & Lim, S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044988 · Cited by 17 · see citing works
Effect of Remote Glucose Monitoring Utilizing Computerized Insulin Dose Adjustment Algorithms: A Pilot Project
Davidson, M. B., & Davidson, S. J. (2019) · Diabetes Therapy · doi:10.1007/s13300-019-0565-y · Cited by 16 · see citing works
High prevalence of steroid-induced glucose intolerance with normal fasting glycaemia during low-dose glucocorticoid therapy: an oral glucose tolerance test screening study
Nowak, K. M., Rdzanek, M., Romanowska‐Próchnicka, K., Nowakowska-Płaza, A., & Papierska, L. (2020) · Lara D. Veeken · doi:10.1093/rheumatology/keaa724 · Cited by 16 · see citing works
Impact of Incretin Therapy on Islet Dysfunction: An Underlying Defect in the Pathophysiology of Type 2 Diabetes
McGill, J. B. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.01.1954 · Cited by 16 · see citing works
Therapeutic Potential of Dipeptidyl Peptidase-IV Inhibitors in Patients With Diabetes Mellitus
Moore, K. B., & Saudek, C. D. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3180ed42dc · Cited by 15 · see citing works
Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia.
Zhao, Y., Zhu, J., Song, G., & Li, X. (2015) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Evaluation of β‐cell mass and function in the Göttingen minipig
Larsen, M. O., Rolin, B., Raun, K., Knudsen, L., Gotfredsen, C., & Bock, T. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00785.x · Cited by 13 · see citing works

Authors: Holman, R. R.
Affiliations: University of Oxford (GB)
Corresponding author: Holman, Rury R
ORCID: Holman, Rury R
Venue: Diabetes Research and Clinical Practice
Publisher: Elsevier BV
Published: 1998-07
Volume: 40
Pages: S21-S25
ISSN: 0168-8227 (ISSN-L)
DOI: 10.1016/s0168-8227(98)00038-2
OpenAlex: W2084644316
Cited by: 197
References: 24
Citations by year: 2026: 6 · 2025: 5 · 2024: 9 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 12 · 2016: 9 · 2015: 8 · 2014: 18 · 2013: 6 · 2012: 11
FWCI: 1.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes Research and Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: alpha-glucosidase inhibitors, acarbose, prediabetes, type 2 diabetes prevention, impaired glucose tolerance, hyperglycemia, beta-cell function, UK Prospective Diabetes Study, sulfonylureas, metformin, insulin therapy
MeSH terms: Diabetes Mellitus, Type 2, Enzyme Inhibitors, Glucosidases, Humans, Hypoglycemic Agents, Prediabetic State, Trisaccharides, Randomized Controlled Trials as Topic, Acarbose

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Assessing the potential for α-glucosidase inhibitors in prediabetic states

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks