Linear mitochondrial genomes: 30 years down the line
Open accessAbstract
At variance with the earlier belief that mitochondrial genomes are represented by circular DNA molecules, a large number of organisms have been found to carry linear mitochondrial DNA. Studies of linear mitochondrial genomes might provide a novel view on the evolutionary history of organelle genomes and contribute to delineating mechanisms of maintenance and functioning of telomeres. Because linear mitochondrial DNA is present in a number of human pathogens, its replication mechanisms might become a target for drugs that would not interfere with replication of human circular mitochondrial DNA.
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Two strains of the same species can have circular or linear mitochondrial DNA.
“This is carried to an extreme where two strains of the same species have circular or linear mtDNA, respectively (reviewed in Nosek et al., 1998).”
From Evolution of striated muscle: Jellyfish and the origin of triploblasty (2005) · cites this paper as Nosek et al., 1998
Mitochondrial DNA structure does not strictly correlate with phylogeny.
“There is, however, no strict correlation of mtDNA structure with phylogeny.”
From Evolution of striated muscle: Jellyfish and the origin of triploblasty (2005) · cites this paper as Nosek et al., 1998
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Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327 · see citing works
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- Authors
- Nosek, J., Tomáška, L., Fukuhara, H., Suyama, Y., & Kováč, L.
- Affiliations
- Comenius University Bratislava (SK)
- Institut Curie (FR)
- University of Pennsylvania (US)
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 14
- Issue
- 5
- Pages
- 184-188
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W1980779505
- Cited by
- 122
- References
- 39
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 9 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 4
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Genetics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- mitochondrial genome evolution, telomeres, telomere maintenance, mitochondrial DNA replication, human pathogens, antiviral drug targets, organelle genomes
- MeSH terms
- Animals, DNA Replication, DNA, Mitochondrial, Biological Evolution, Humans, Telomere
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