Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

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DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

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Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

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Identification of normal and pathological aging in prospectively studied nondemented elderly humans

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Internal Clocks, mGluR7 and Microtubules: A Primer for the Molecular Encoding of Target Durations in Cerebellar Purkinje Cells and Striatal Medium Spiny Neurons

Yousefzadeh, S. A., Hesslow, G., Shumyatsky, G. P., & Meck, W. H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00321 · Cited by 6

Beyond Secretases

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Small‐interfering‐RNA‐mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells

Choi, M., Kim, E.-A. L., Huh, J., Choi, S.-Y., Cho, S. W., & Yang, S. (2008) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20070190 · Cited by 5

Quercetin reduces APP expression, oxidative stress and mitochondrial dysfunction in the N2a/APPswe cells via ERK1/2 and AKT pathwaysPreprint

Tang, Z., Guo, M., Peng, Y., Zhang, T., Xiao, Y. C., Ni, R., & Qi, X. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.18.508406 · Cited by 4

A Network Pharmacology Approach to Explore the Potential Mechanism of Ficus religiosa against Alzheimer’s Disease

Fernandes, Z., Sahana, K. D., & Dattatreya, K. S. (2022) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.12.3.13 · Cited by 4

Identification of Vascular Genes Differentially Expressed in the Brain of Patients with Alzheimer's Disease

Jara-Medina, K., Lillo, L., Lagunas, C., Cabello, G., & Valenzuela-Melgarejo, F. J. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611298073240612050741 · Cited by 4

Analysis of Why Alzheimer’s Dementia Never Spontaneously Reverses, Suggests the Basis for Curative Treatment

Fessel, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144873 · Cited by 5

Molecular Aspects of Memory Dysfunction in Alzheimer’s Disease

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Multi-kinase-mediated alterations in Tau phosphorylation, synaptic proteins, and choline metabolism in a human neuronal in vitro model exposed to the elastin-derived hexapeptide VGVAPG

Skóra, B., Piechowiak, T., & Szychowski, K. A. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110781 · Cited by 3

Neuroproteomic Analysis after SARS-CoV-2 Infection Reveals Overrepresented Neurodegeneration Pathways and Disrupted Metabolic Pathways

Basak, I., Harfoot, R., Palmer, J. E., Kumar, A., Quiñones‐Mateu, M. E., Schweitzer, L., & Hughes, S. M. (2023) · Biomolecules · doi:10.3390/biom13111597 · Cited by 4

Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment

Tripathi, S., Sharma, Y., & Kumar, D. (2024) · Protein and Peptide Letters · doi:10.2174/0109298665348075241121071614 · Cited by 3

Study on the mechanism of Xanthoceras sorbifolia Bunge oil in the treatment of Alzheimer’s disease by an integrated “network pharmacology-metabolomics” strategy

Du, L., Sun, Y., Gan, Y., Wang, L., Li, X., Yan, S., Xiao, X. H., Li, S., & Jin, H. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2499700 · Cited by 3

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Giannelli, S. G., Eroli, F., Loera‐Valencia, R., Leoni, V., Latorre‐Leal, M., Testa, G., Staurenghi, E., Sottero, B., Gamba, P., Maioli, S., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107029 · Cited by 3

Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analysesPreprint

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Going beyond ATP binding site as a novel inhibitor design strategy for tau protein kinases in the treatment of Alzheimer's disease: A review

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Inhibitors of Tau-Phosphorylating Kinases

Fallacara, A. L., Trist, I. M. L., Schenone, S., & Botta, M. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_17 · Cited by 2

Relationship of ERK1/2 phosphorylation to D1 dopamine receptor activation, behavioral sensitization, and structural plasticity in the neonate 6-hydroxydopamine-lesioned rat

Papadeas, S. T. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/xraa-7j71 · Cited by 2

Methionine Oxidation: Implication in Protein Regulation, Aging, and Aging‐Associated Diseases

Moskovitz, J., & Oien, D. B. (2008) · Wiley eBooks · doi:10.1002/9780470475973.ch11 · Cited by 2

Modulation of ERK1/MAPK3 potentiates ERK nuclear signalling, facilitates neuronal cell survival and improves memory in mouse models of neurodegenerative disordersPreprint

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Letter to the Editor: Intense Exercise and Associated Blood–Brain Barrier Leakiness and Systemic Inflammation at the Time of Brain Injury May Be Relevant to Understanding Why Only Sports-Related Concussions Are Associated With Chronic Traumatic Encephalopathy

Butler, T. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0505 · Cited by 1

Molecular Mechanisms of Synaptic Plasticity and Memory and Their Dysfunction in Alzheimer's Disease ☆

Stephens, G. S., You, J. C., Fu, C.-H., & Chin, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21126-7 · Cited by 1

Protective effects of the Sophorae Fructus on cognitive impairment and neuroinflammatory alteration in an Aβ1-42-infused Alzheimer’s disease mouse model

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The alteration of neurogenesis and pathological markers in alzheimer’s disease after deep brain stimulation

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Differential gene expression studies to explore the molecular mechanism of drug resistance in Leishmania donovani field isolates

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Overinhibition of mitogen-activated protein kinase inducing tau hyperphosphorylation

Li, H., Chen, J., Shi-jie, L., Zhang, J. Y., Qun, W., & Wang, J. (2005) · Wuhan University Journal of Natural Sciences · doi:10.1007/bf02831155

Characterization of proteins involved in the production of β-Amyloid peptides and tau hyperphosphorlation in Familial Alzheimer’s Disease

Ocampo, B., & Andrés, Á. (2012)

Animal Models of Tauopathy

Duff, K., Krishnamurthy, P., Planel, E., & Hutton, M. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-35135-3_13

Sinalização intracelular desencadeada por concentrações subtóxicas de estreptozotocina em células neuro-2A: modelo in vitro de neurodegeneração associada à doença de Alzheimer.

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Role of P70 S6 kinase in the formation of tau pathologies in Alzheimer´s disease

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Estudio de las vías de supervivencia y muerte neuronal en modelos de la enfermedad de Huntington

Rubia, P. P. (2010) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

Modulation of growth factor-induced ERK signaling by the microtubule associated protein tau

Leugers, C. J. (2010) · doi:10.17077/etd.44cmdeo5

The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer Disease

Tang, Z. (2014) · Figshare

The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease

Agholme, L. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

The Effects of Androgens on Hippocampal Synaptic Plasticity in Male Mammals

Mendell, A. L. (2014) · The Atrium (University of Guelph)

Transcriptional Control of Nerve Cell Death, Survival and Repair

Cameron, R., & Dragunow, M. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_12

Discovery-Based Transcriptome and Translatome Profiling Reveals Molecular Pathways in the Pathogenesis of Alzheimer’s Disease

McKeever, P. M. (2018) · TSpace (University of Toronto)

Intracellular Responses of Glial Cells To Monomeric Tau Protein Are Closely Mediated By Heparan Sulfate Proteoglycans (HSPGs)Preprint

Song, L., Oseid, D. E., Wells, E. A., Coaston, T. N., & Robinson, A. S. (2021) · Research Square · doi:10.21203/rs.3.rs-647000/v1

Oxidative Stress Associated Signal Transduction Cascades in Alzheimer Disease

Petersen, R. B., Nunomura, A., Lee, H., Casadesús, G., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60327-342-8_8

Tenuigenin ameliorates Alzheimer’s disease by targeting MAP2K1: integrated evidence from network pharmacology and experimental validation

Fu, C., Kan, Y., Guo, K., Jiang, L., Zhang, Y., Dong, H., & Xie, J. (2025) · Neuroreport · doi:10.1097/wnr.0000000000002239

Emodin: Its effects are largely due to hormesis

Calabrese, E. J., Pressman, P., Hayes, A. W., Agathokleous, E., Dhawan, G., Kapoor, R., & Calabrese, V. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.115984

A human gut-BBB-brain microphysiological model for studying Alzheimer’s disease

Deng, Y.-S., Wang, W., Wang, F., Ma, G., Lin, J., Yan, C., Zhou, Y., Wang, L.-Y., Gong, X.-Q., Sun, L., et al. (2026) · Lab on a Chip · doi:10.64898/2026.02.24.707716

Novel FUS and CHCHD10 models to investigate pathogenic mechanisms in Amyotrophic Lateral Sclerosis

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The emerging role of polo-like kinase 2 in Alzheimer's disease

Martínez-Drudis, L., Sheta, R., Musiol, D., Teixeira, M., & Oueslati, A. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115806

Exploring nonylphenol as a potential environmental contributor to Alzheimer’s disease: A hypothesis-generating study integrating computational analyses and experimental evidence

Wang, X., Liu, T., Li, S., Yao, D., Ding, R., Cai, B., Wang, D., Xu, Y., & Wang, Y. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103573

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

Been, M., Lambert, E., Serna, A., Balvert, A. C. G., Heisinger, S., Kreshpani, M., Dorsthorst-Maas, C. T., Paškevičiūtė, P., Arias, H. R., Beijer, D., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117507

BindingDB Entry 50022831: A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer's disease (AD).

BindingDB (2026) · UC San Diego · doi:10.7270/q2c53rpz

Mechanisms Promoting ERK-Dependent Neuronal Oxidative Toxicity

Levinthal, D. J. (2004) · D-Scholarship@Pitt (University of Pittsburgh)

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

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Distribution, levels, and activation of MEK1 in Alzheimer's disease

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Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Ferrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239

P3‐025: Chronic inhibition of the MEK/ERK pathway fails to delay disease progression in a transgenic animal model of tauopathy

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MAP Kinase Signaling Cascade Dysfunction Specific to Alzheimer's Disease in Fibroblasts

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