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Manganese Induces Tau Hyperphosphorylation through the Activation of ERK MAPK Pathway in PC12 Cells

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Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

Qi, H., Prabakaran, S., Cantrelle, F., Chambraud, B., Gunawardena, J., Lippens, G. M., & Landrieu, I. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.700914 · Cited by 73

Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

Zhou, X., Li, X., Björkdahl, C., Sjögren, M. J. C., Alafuzoff, I. I., Soininen, H. S., Grundke, I., Iqbal, K., Winblad, B. G., & Pei, J.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.006 · Cited by 65

Transcriptional regulation of homeostatic and disease‐associated‐microglial genes by IRF1, LXRβ, and CEBPα

Gao, T., Jernigan, J. E., Raza, S. A., Dammer, E. B., Xiao, H., Seyfried, N. T., Levey, A. I., & Rangaraju, S. (2019) · Glia · doi:10.1002/glia.23678 · Cited by 68

The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ1-42 Oligomers in Primary Cortical Neurons

Piccialli, I., Tedeschi, V., Caputo, L., Amato, G., De Martino, L., De Feo, V., Secondo, A., & Pannaccione, A. (2021) · Antioxidants · doi:10.3390/antiox10060937 · Cited by 64

Activating transcription factor 2 expression in the adult human brain: Association with both neurodegeneration and neurogenesis

Pearson, A. G., Curtis, M. A., Waldvogel, H. J., Faull, R. L. M., & Dragunow, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.029 · Cited by 63

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

Gui, Y.-X., Wang, X., Kang, W., Zhang, Y., Zhang, Y., Zhou, Y. F., Quinn, T. J., Liu, J., & Chen, S. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.001 · Cited by 67

Distribution, levels, and activation of MEK1 in Alzheimer's disease

Zhu, X.-W., Sun, Z., Lee, H.-G., Siedlak, S., Perry, G., & Smith, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01820.x · Cited by 60

Zinc in Cognitive Impairment and Aging

Sun, R., Wang, J., Feng, J., & Cao, B. (2022) · Biomolecules · doi:10.3390/biom12071000 · Cited by 70

PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK‐3

Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.064 · Cited by 60

Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline

Cai, X., Zhang, K., Xie, X., Zhu, X., Feng, J., Jin, Z., Zhang, H., Tian, M., & Chen, H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119678 · Cited by 59

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

Chen, D., Mei, Y., Kim, N., Lan, G., Gan, C., Fan, F., Zhang, T., Xia, Y., Wang, L., Lin, C., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12665 · Cited by 59

Activation of ERK1/2 MAP kinases in Familial Amyloidotic Polyneuropathy

Monteiro, F. A., Sousa, M. M., Cardoso, I., do Amaral, B., Guimarães, A., & Saraiva, M. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03716.x · Cited by 57

Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

Ruegsegger, G. N., Manjunatha, S., Summer, P., Gopala, S., Zabeilski, P., Dasari, S., Vanderboom, P. M., Lanza, I. R., Klaus, K. A., & Nair, K. S. (2019) · The FASEB Journal · doi:10.1096/fj.201802043r · Cited by 57

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

Li, L., Wu, X., Zhao, X.-J., Xu, L., Pan, C., & Zhang, Z. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01744-1 · Cited by 56

Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding

Leugers, C. J., & Lee, G. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105387 · Cited by 60

Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains

Pearson, A. G., Byrne, U. T. E., MacGibbon, G. A., Faull, R. L. M., & Dragunow, M. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.031 · Cited by 51

Alleviating Neurodegeneration by an Anticancer Agent

Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Tanaka, F., & Sobue, G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.012 · Cited by 50

Heat Shock Protein 90 Indirectly Regulates ERK Activity by Affecting Raf Protein Metabolism

Dou, F., Yuan, L.-D., & Zhu, J. (2005) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2005.00069.x · Cited by 49

Chronic Arsenic Exposure Increases Aβ(1–42) Production and Receptor for Advanced Glycation End Products Expression in Rat Brain

Niño, S. A., Martel‐Gallegos, G., Castro‐Zavala, A., Ortega-Berlanga, B., Delgado, J. M., Hernández‐Mendoza, H., Romero-Guzmán, E. T., Ríos-Lugo, M. J., Rosales‐Mendoza, S., Jiménez-Capdeville, M. E., et al. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.7b00215 · Cited by 50

Brain Endothelial Cell-Derived Exosomes Induce Neuroplasticity in Rats with Ischemia/Reperfusion Injury

Gao, B., Zhou, S.-T., Sun, C., Cheng, D., Zhang, Y., Li, X., Zhang, L., Zhao, J., Xu, D., & Bai, Y. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00089 · Cited by 50

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

Trojanowski, J., Mawal-Dewan, M., Schmidt, M., Martin, J. A., & Lee, V. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91286-2 · Cited by 91

Distribution, levels, and activation of MEK1 in Alzheimer's disease

Zhu, X.-W., Sun, Z., Lee, H.-G., Siedlak, S., Perry, G., & Smith, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01820.x · Cited by 60

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Ferrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239

P3‐025: Chronic inhibition of the MEK/ERK pathway fails to delay disease progression in a transgenic animal model of tauopathy

Bose, S., Cavallini, A., Murray, T. K., Baschirotto, L., Czilli, D. L., Cella, C. V., Ward, M., Hanmer, J. M., Sims, H., Eberle, E. L., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1243

MAP Kinase Signaling Cascade Dysfunction Specific to Alzheimer's Disease in Fibroblasts

Zhao, W.-Q., Ravindranath, L., Mohamed, A. S., Zohar, O., Chen, G. H., Lyketsos, C. G., Etcheberrigaray, R., & Alkon, D. L. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0520 · Cited by 62