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Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease
Abstract
The abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) has been proposed to involve the extracellular-signal-regulated protein kinase (ERK) of the mitogen-activated protein (MAP) kinase family. ERK is phosphorylated and thereby activated by MAP kinase kinase (MEK). In the present study, we determined the intracellular and regional distribution of the active forms of both MEK1/2 and ERK1/2, i.e. p-MEK1/2 and p-ERK1/2 in the entorhinal, hippocampal, and temporal cortices of 49 brains staged for neurofibrillary changes according to Braak and Braak's protocol. We found that p-MEK1/2 and p-ERK1/2 were present in the initial stages of neurofibrillary degeneration in the projecting neurons in the transentorhinal region, and extended into other brain regions co-incident with the progressive sequence of neurofibrillary changes up to and including Braak stage VI. It appeared that the accumulation of p-MEK1/2 and p-ERK1/2 was initiated in the cytoplasm of pretangle neurons in varying size granules, which grew into large aggregates co-existing with the progressive development of neurofibrillary tangles. Accumulation of p-MEK1/2 and p-ERK1/2 was found in cases with stages I-III neurofibrillary degeneration, which were devoid of amyloid deposition. These data provide direct in situ evidence consistent with the possible involvement of MAP kinase pathway in the hyperphosphorylation of tau and the presence of this lesion before deposition of beta-amyloid in AD.
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“ERK can phosphorylate tau (29), and elevated activity of MAPK/ERK has been reported in several tauopathies and may play a role in early stages of neurofibriliary tangle (NFT) formation (82,130,131).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [130]
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Self-citationGrundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676
Self-citationNeurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,876
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
Grundke, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38495-8 · Cited by 1,780
Self-citationAnderson, N. G., Maller, J. L., Tonks, N. K., & Sturgill, T. W. (1990) · Nature · doi:10.1038/343651a0 · Cited by 1,064
Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769
Self-citationDEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE
Iqbal, K., Zaidi, T., Wen, G. Y., Grundke, I., MERZ, P. A., Shaikh, S., Wisniewski, H., Alafuzoff, I. I., & Winblad, B. G. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92134-3 · Cited by 737
Self-citationHanger, D. P., Hughes, K., Woodgett, J. R., Brion, J.-P., & Anderton, B. H. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90774-2 · Cited by 737
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643
Research works printed but not linked: 2
- Campbell, 1987, Alzheimer’s plaques and tangles: a controlled and enhanced silver-staining method, Soc. Neurosci. Abstr., 13, H678
- Pei, 1999, The distribution of active form of mitogen activated protein (MAP) kinase in Alzheimer’s neurofibrillary pathology, Soc. Neurosci. Abstr., 25, 1181
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Veeranna, Yang, D., Lee, J., Vinod, K. Y., Stavrides, P. H., Amin, N. D., Pant, H. C., & Nixon, R. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.12.001 · Cited by 46
Lee, J., & Kim, K. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20899 · Cited by 49
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d’Abramo, C., Ricciarelli, R., Pronzato, M. A., & Davies, P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03931.x · Cited by 46
Dozza, B., Smith, M. A., Perry, G. L., Tabaton, M., & Strocchi, P. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02413.x · Cited by 43
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Miras‐Portugal, M. T., Queipo, M. J., Gil‐Redondo, J. C., Ortega, F., Gómez‐Villafuertes, R., Gualix, J., Delicado, E. G., & Pérez‐Sen, R. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.012 · Cited by 43
Zuo, H., Lin, T., Wang, D., Peng, R., Wang, S., Gao, Y., Xu, X., Zhao, L., Wang, S., & Su, Z.-T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8831-5 · Cited by 39
Jarzynka, M. J., Passey, D. K., Johnson, D. A., Konduru, N. V., Fitz, N. F., Radio, N. M., Rasenick, M. M., Benloucif, S., Melan, M. A., & Witt‐Enderby, P. A. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00644.x · Cited by 39
Susen, K., & Blöchl, A. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0671-3 · Cited by 38
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Tang, Z., Baykal, A. T., Gao, H., Quezada, H. C., Zhang, H., Bereczki, E., Serhatlı, M., Baykal, B., Acıoğlu, Ç., Wang, S., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr500192g · Cited by 37
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Gerschütz, A., Heinsen, H., Grünblatt, E., Wagner, A. K., Bartl, J., Meißner, C., Fallgatter, A. J., Al‐Sarraj, S., Troakes, C., Ferrer, I., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131280 · Cited by 37
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van Eersel, J., Bi, M., Ke, Y. D., Hodges, J. R., Xuereb, J. H., Gregory, G. C., Halliday, G. M., Götz, J., Kril, J. J., & Ittner, L. M. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0293-y · Cited by 38
Donison, N. S., Palik, J., Volkening, K., & Strong, M. J. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00842-z · Cited by 42
Rroji, O., Kumar, A., Karuppagounder, S. S., & Ratan, R. R. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105145 · Cited by 36
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Indrigo, M. T., Morella, I., Orellana, D. I., d’Isa, R., Papale, A., Parra, R., Gurgone, A., Lecca, D., Cavaccini, A., Tigaret, C. M., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202215984 · Cited by 35
Leugers, C. J., Koh, J. Y., Hong, W., & Lee, G. S. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00161 · Cited by 34
An, W., Pei, J.-J., Nishimura, T., Winblad, B. G., & Cowburn, R. F. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.11.010 · Cited by 35
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Yi, K. D., Covey, D. F., & Simpkins, J. W. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05805.x · Cited by 35
Mezache, L., Mikhail, M., Garofalo, M., & Nuovo, G. J. (2015) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000147 · Cited by 34
Kumaran, K. R., Yunusa, S., Perimal, E. K., Wahab, H. A., Müller, C. P., & Hassan, Z. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220666 · Cited by 39
Jin, Y. N., Chen, P., Watson, J. A., Walters, B. J., Phillips, S. E., Green, K., Schmidt, R. E., Wilson, J. A., Johnson, G. V. W., Roberson, E. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047884 · Cited by 34
Su, L., Zhang, R., Chen, Y., Zhu, Z., & Ma, C. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000464119 · Cited by 33
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
Brody, A. H., Nies, S. H., Guan, F., Smith, L. M., Mukherjee, B., Salazar, S. A., Lee, S., Lam, T. K. T., & Strittmatter, S. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00526-y · Cited by 36
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Mei, M., Su, B., Harrison, K. H., Chao, M. P., Siedlak, S., Previll, L. A., Jackson, L., Cai, D., & Zhu, X.-W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04174.x · Cited by 34
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Bonda, D., Castellani, R. J., Zhu, X., Nunomura, A., Lee, H., Perry, G. L., & Smith, M. A. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717131 · Cited by 32
Damjanac, M., Rioux Bilan, A., Paccalin, M., Pontcharraud, R., Fauconneau, B., Hugon, J., & Page, G. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.09.008 · Cited by 32
Jeong, A., Cheng, S., Zhong, R., Bennett, D. A., Bergö, M. O., & Li, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01231-5 · Cited by 31
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Hoe, H.-S., Pocivavsek, A., Dai, H., Chakraborty, G., Harris, D. C., & Rebeck, G. W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.035 · Cited by 30
Mai, M., Guo, X., Huang, Y. M., Zhang, W., Xu, Y., Zhang, Y., Bai, X., Wu, J., & Zu, H. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02945-w · Cited by 28
Sayed, N. S. E., Kandil, E. A., & Ghoneum, M. H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5525306 · Cited by 31
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Martínez‐Cué, C., & Rueda, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186906 · Cited by 26
Tiwari, V., Mishra, A., Singh, S., Mishra, S. K., Sahu, K. K., Parul, P., Kulkarni, M. J., Shukla, R., & Shukla, S. (2021) · Brain Research · doi:10.1016/j.brainres.2020.147261 · Cited by 28
Song, L., Oseid, D. E., Wells, E. A., Coaston, T. N., & Robinson, A. S. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01943-2 · Cited by 28
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Self-citationAgholme, L., Nath, S., Domert, J., Marcusson, J. O., Kågedal, K., & Hallbeck, M. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.11.001 · Cited by 25
Scarpa, M., Molloy, C., Jenkins, L., Strellis, B., Budgett, R. F., Hesse, S., Dwomoh, L., Marsango, S., Tejeda, G. S., Rossi, M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107389118 · Cited by 25
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Yu, H., Wang, D., Zou, L., Zhang, Z., Xu, H., Zhu, F., Ren, X., Xu, B., Yuan, J., Liu, J., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2163-6 · Cited by 25
Chen, Q., Lai, C., Chen, F., Ding, Y., Zhou, Y., Su, S., Ni, R., & Tang, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.821521 · Cited by 23
Nishikawa, T., Takahashi, T., Nakamori, M., Hosomi, N., Maruyama, H., Miyazaki, Y., Izumi, Y., & Matsumoto, M. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12288 · Cited by 23
Echeverrı́a, V., Ducatenzeiler, A., Chen, C. H., & Cuello, A. C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.057 · Cited by 24
Klafki, H., Lewczuk, P., Kamrowski-Kruck, H., Maler, J., Müller, K., Peters, O., Heuser, I., Jessen, F., Popp, J., Frölich, L., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1167 · Cited by 23
Chiu, Y., Lin, T., Chen, C., Lin, C., Teng, Y.-S., Lin, C., Sun, Y., Hsieh‐Li, H. M., Su, M., Lee‐Chen, G., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3058861 · Cited by 22
Catalina, M. O., Bermejo, M. C., Argent, R., Alonso, J. C., Centeno, F., & Lorenzo, M. J. V. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.11.004 · Cited by 23
Mendell, A. L., Chung, B. Y. T., Creighton, C. E., Kalisch, B. E., Bailey, C. D. C., & MacLusky, N. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.023 · Cited by 24
López-Toledo, G., Silva‐Lucero, M., Herrera‐Díaz, J., García, D.-E., Arias‐Montaño, J., & Cárdenas‐Aguayo, M. D. C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.921573 · Cited by 20
Kazerouni, A., Nazeri, M., Karimzadeh, A., SoukhakLari, R., Moezi, L., Pirsalami, F., & Moosavi, M. (2020) · Neurological Research · doi:10.1080/01616412.2019.1709142 · Cited by 21
Mendell, A. L., Creighton, S. D., Wilson, H. A., Jardine, K. H., Isaacs, L., Winters, B. D., & MacLusky, N. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.011 · Cited by 21
Nizzari, M., Barbieri, F., Gentile, M. T., Passarella, D., Caorsi, C., Diaspro, A., Taglialatela, M., Pagano, A., Colucci-D'Amato, L., Florio, T., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101590 · Cited by 21
Mendell, A. L., & MacLusky, N. J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.012 · Cited by 23
Li, W. Y., Lee, C. Y., Lee, K. M., Zhang, G., Lü, A., & Yue, K. K. M. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s382927 · Cited by 19
Tan, L., Chen, X., Wang, W., Zhang, J., Li, S., Zhao, Y., Wang, J., & Luo, A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.11.008 · Cited by 19
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Kim, Y., Liu, G., Leugers, C. J., Mueller, J. D., Francis, M. B., Hefti, M. M., Schneider, J. A., & Lee, G. S. (2019) · Journal of Cell Science · doi:10.1242/jcs.229054 · Cited by 19
Nayeem, N., Kerr, F., Naumann, H., Linehan, J., Lovestone, S., & Brandner, S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.014 · Cited by 19
Brezováková, V., Syková, E., & Jadhav, S. (2022) · Cells · doi:10.3390/cells11091429 · Cited by 19
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Dumbacher, M., Dooren, T. V., Princen, K., Witte, K. D., Farinelli, M., Lievens, S., Tavernier, J. H., Dehaen, W., Wera, S., Winderickx, J., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0283-3 · Cited by 18
Liu, Y., Cao, L., Zhang, X., Liang, Y., Xu, Y., & Zhu, C. (2019) · Neural Plasticity · doi:10.1155/2019/4168472 · Cited by 18
Chen, L., Zhou, L., Yu, P., Fang, F., Jiang, L., Fei, J., Xiao, H., & Wang, J. (2019) · The Journal of Toxicological Sciences · doi:10.2131/jts.44.493 · Cited by 18
Andrés‐Benito, P., Carmona, M., Pirla, M. J., Torrejón-Escribano, B., del Rı́o, J. A., & Ferrer, I. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.10.023 · Cited by 18
Choi, M., Lee, Y., & Cho, S. (2017) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-017-2812-2 · Cited by 18
Iqbal, J., Zhang, K., Jin, N., Zhao, Y., Liu, Q., Ni, J., & Shen, L. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24309 · Cited by 18
Chalatsa, I., Arvanitis, D. A., Mikropoulou, E. V., Giagini, A. T., Papadopoulou‐Daifoti, Z., Aligiannis, N., Halabalaki, M., Tsarbopoulos, A., Skaltsounis, A., & Sanoudou, D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170862 · Cited by 17
Kim, M., Kim, M. J., Lee, C., Lee, J., Kim, S. S., Hong, S., Kim, H. T., Seo, J., Yoon, K., & Han, S. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01073-2 · Cited by 17
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Kuusisto, E. (2004) · Cited by 16
Lasorsa, A., Merzougui, H., Cantrelle, F., Sicoli, G., Dupré, E., Hanoulle, X., Belle, V., Smet‐Nocca, C., & Landrieu, I. (2023) · Biophysical Chemistry · doi:10.1016/j.bpc.2023.107155 · Cited by 14
Alkam, T., Nitta, A., Furukawa‐Hibi, Y., Niwa, M., Mizoguchi, H., Yamada, K., & Nabeshima, T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.028 · Cited by 15
Su, L., Du, H., Dong, X., Zhang, X., & Lou, Z. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-128 · Cited by 15
Xu, H., Zhou, W., Zhan, L., Sui, H. X., Zhang, L., Zhao, C., & Lu, X. (2020) · Aging · doi:10.18632/aging.103894 · Cited by 15
Taubel, J., Nelson, N. R., Bansal, A., Curran, G. L., Wang, L., Wang, Z., Berg, H. M., Vernon, C. J., Min, H.-K. P., Larson, N. B., et al. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00126 · Cited by 16
Tang, Y., Zhao, D., Yang, F., Pang, G., Sun, Z., Chang, J. K., & Dou, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.134352 · Cited by 15
Raju, H. B., Tsinoremas, N. F., & Capobianco, E. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00168 · Cited by 14
Key network approach reveals new insight into Alzheimer's disease
Schluesener, J. K., Zhu, X., Schluesener, H. J., Wang, G., & Ao, P. (2014) · IET Systems Biology · doi:10.1049/iet-syb.2013.0047 · Cited by 13
Hernández‐Ortega, K., & Arias, C. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23106 · Cited by 13
Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration
Ding, Y., Lei, L., Lai, C., & Tang, Z. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180917 · Cited by 13
Haque, N., Gong, C., Sengupta, A., Iqbal, K., & Grundke, I. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.07.001 · Cited by 13
Self-citationNunes, M. J., Moutinho, M., Milagre, I., Gama, M. J., & Rodrigues, E. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m027680 · Cited by 12
Alalwany, R. H., Hawtrey, T. J., Morgan, K., Morris, J. C., Donaldson, L. F., & Bates, D. O. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1181626 · Cited by 11
Overactivated mitogen-activated protein kinase by anisomycin induces tau hyperphosphorylation.
Wang, Q., Zhang, J.-Y., Liu, S. J., & Li, H. L. (2008) · PubMed · Cited by 11
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Santos, D., Coelho, T., Alves‐Ferreira, M., Sequeiros, J., Mendonça, D. M., Alonso, I. D. C. M. P., Lemos, C., & Sousa, A. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.380 · Cited by 11
Wang, Y., Shi, Z., Zhang, Y., Yan, J., Yu, W., & Chen, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.595360 · Cited by 11
Harun, Z. Z., Azhar, A. A., Kim, Y. J., Ibrahim, F. W., Ng, M. H., Tan, J. K., & Lokanathan, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13122931 · Cited by 10
Dent, P., Booth, L. A., Roberts, J. L., Poklepovic, A. S., Martinez, J., Cridebring, D., & Reiman, E. M. (2022) · Aging · doi:10.18632/aging.204337 · Cited by 11
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Metadata
- Authors
- Pei, J.-J., Braak, H., An, W.-L., Winblad, B., Cowburn, R. F., Iqbal, K., & Grundke-Iqbal, I.
- Affiliations
- Karolinska Institutet (SE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Pei, Jin-Jing
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 109
- Issue
- 1-2
- Pages
- 45-55
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W2046431926
- Cited by
- 247
- References
- 62
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 19 · 2021: 12 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 11
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag008076-09, 5r01ns018105-17)
- National Institute on Aging (AG19158, AG 08076, R01AG019158)
- National Institute of Neurological Disorders and Stroke (NS 18105)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary degeneration, tau hyperphosphorylation, ERK1/2, MEK1/2, MAPK signaling, neurofibrillary tangles, Braak staging, entorhinal cortex, hippocampus, temporal cortex, amyloid deposition
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Animals, Brain, Female, Fluorescent Dyes, Humans, Immunohistochemistry, Male, Middle Aged, Neurofibrils, Neurons, Phosphorylation, Protein-Tyrosine Kinases, Up-Regulation, tau Proteins, Protein Serine-Threonine Kinases, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinase 3, MAP Kinase Kinase 1, MAP Kinase Kinase 2
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