Cited by 150Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

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Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging

Barrientos, Antoni, Casademont, Jordi, Cardellach, Francesc, Estivill, Xavier, Urbano-Marquez, Alvaro, Nunes, Virginia·1997·Molecular Brain Research

DOI 10.1016/s0169-328x(97)00278-7

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Abstract

The contribution of the mitochondrial genetic system in the degenerative processes of senescence remains unclear. This study deals with age-related changes in brain mtDNA expression in humans. Brain tissue from the frontal lobe cortex was obtained from autopsy of 13 humans aged between 21 and 84 years. No structural changes were detected in mtDNA, increased mtDNA content and reduced steady-state level of mitochondrial transcripts and transcription ratio (mtRNA/mtDNA) were associated with aging. These findings suggest that the increase of the mtDNA levels could be considered as an inefficient compensatory mechanism to maintain the normal levels of mtRNA transcripts. This unbalanced mitochondrial condition could play a role in the process of senescence in human brain.

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Authors: Barrientos, A., Casademont, J., Cardellach, F., Estivill, X., Urbano-Marquez, A., & Nunes, V.
Affiliations: Hospital Clínic de Barcelona (ES)
Corresponding author: Nunes, Virginia
ORCID: Barrientos, Antoni
Casademont, Jordi
Cardellach, Francesc
Estivill, Xavier
Nunes, Virginia
Venue: Molecular Brain Research
Publisher: Elsevier BV
Published: 1997-12
Volume: 52
Issue: 2
Pages: 284-289
ISSN: 0169-328X (ISSN-L)
DOI: 10.1016/s0169-328x(97)00278-7
OpenAlex: W2018590086
Cited by: 149
References: 26
Citations by year: 2024: 5 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 8
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Generalitat de Catalunya
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial DNA, mitochondrial RNA, brain aging, mitochondrial transcription, senescence, compensatory mechanisms, human brain
MeSH terms: RNA, Mitochondrial, Adult, Aged, Aged, 80 and over, Aging, DNA, Mitochondrial, DNA, Ribosomal, Frontal Lobe, Humans, Middle Aged, Reference Values, Regression Analysis, RNA, RNA, Ribosomal, 18S, Transcription, Genetic

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Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging

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