Cited by 81Mitochondrial Function and PathologyAutophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Treating neurodegeneration by modifying mitochondria: potential solutions to a “complex” problem

Swerdlow, Russell H.·2007·Antioxidants & Redox Signaling

Abstract

Mitochondria function differently in aged brains than they do in young brains. Consistently reported changes include reduced electron transport chain (ETC) enzyme activities, reduced phosphorylation of ADP, and increased reactive oxygen species (ROS) production. Various neurodegenerative diseases are also associated with changes in mitochondrial function, and these changes both recapitulate and extend those seen in "normal" aging. Unfortunately, attempts to treat neurodegenerative diseases by treating mitochondria-related pathology have thus far minimally impacted affected patients. A better understanding of how mitochondrial function changes in aging and neurodegenerative diseases, though, now suggests new approaches to mitochondrial therapy may prove more efficacious. Increasing ETC capacity, increasing oxidative phosphorylation, or decreasing mitochondrial ROS may yet prove useful for the treatment of brain aging and neurodegenerative diseases, and accomplishing this seems increasingly feasible. This review will discuss the role of mitochondrial function and dysfunction in aging and neurodegenerative diseases, and will focus on potential treatment strategies.

Integrity signals

Registry

Crossref · 10.1089/ars.2007.1676

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183 of 183 references verified0 citation errors · 0 not checkable

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Authors
Swerdlow, R. H.
Affiliations
University of Virginia Medical Center (US)
Corresponding author
Swerdlow, Russell H.
Venue
Antioxidants & Redox Signaling
Published
2007-10
Volume
9
Issue
10
Pages
1591-1604
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W2070110482
Cited by
81
References
183
Citations by year
2026: 1 · 2025: 3 · 2023: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
3.84
Type
journal article
Language
en
Open access
closed
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (R01AG022407, R01AG22407)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
mitochondrial dysfunction, neurodegenerative diseases, brain aging, electron transport chain, oxidative phosphorylation, reactive oxygen species, mitochondrial therapy, ADP phosphorylation, mitochondria-targeted antioxidants
MeSH terms
Brain, Humans, Mitochondria, Neurodegenerative Diseases

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