Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works

Antioxidant and redox regulation of gene transcription

Sen, C. K., & Packer, L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635688 · Cited by 1,996 · see citing works

Diseases of the mitochondrial DNA

Wallace, D. C. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005523 · Cited by 1,319 · see citing works

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

Burdon, R. H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00198-s · Cited by 1,166 · see citing works

An essential role for free radicals and derived species in signal transduction

Lander, H. M. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.2.9039953 · Cited by 908 · see citing works

Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin

Rothe, G., & Valet, G. (1990) · Journal of Leukocyte Biology · doi:10.1002/jlb.47.5.440 · Cited by 870 · see citing works

Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells

Robin, E. D., & Wong, R. J. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041360316 · Cited by 656 · see citing works

Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

LEE, H.-C., YIN, P.-H., LU, C.-Y., CHI, C.-W., & WEI, Y.-H. (2000) · Biochemical Journal · doi:10.1042/bj3480425 · Cited by 551 · see citing works

Oxidants in mitochondria: from physiology to diseases

Richter, C., Gogvadze, V. G., Laffranchi, R., Schlapbach, R., Schweizer, M., Suter, M., Walter, P. B., & Yaffee, M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00012-s · Cited by 543 · see citing works

CROSSTALK BETWEEN NUCLEAR AND MITOCHONDRIAL GENOMES

Poyton, R. Ο., & McEwen, J. E. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.003023 · Cited by 499 · see citing works

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

Chen, Q. M., Bartholomew, J. C., Campisi, J., Acosta, M., REAGAN, J. D., & Ames, B. N. (1998) · Biochemical Journal · doi:10.1042/bj3320043 · Cited by 442 · see citing works

Mitochondrial decay in aging

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00024-x · Cited by 391 · see citing works

Oxidative Stress and Mitochondrial DNA Mutations in Human Aging

Wei, Y. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-217-44205 · Cited by 361 · see citing works

Mitochondrial role in life and death of the cell.

Lee, H.-C., & Wei, Y.-H. (2000) · Journal of Biomedical Sciences · doi:10.1007/bf02255913 · Cited by 350 · see citing works

Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle

Bogenhagen, D. F., & Clayton, D. A. (1977) · Cell · doi:10.1016/0092-8674(77)90286-0 · Cited by 312 · see citing works

Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line

Mancini, M., Anderson, B. O., Caldwell, E., Sedghinasab, M., Paty, P. B., & Hockenbery, D. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.2.449 · Cited by 306 · see citing works

What regulates mitochondrial DNA copy number in animal cells?

Moraes, C. T. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02238-7 · Cited by 299 · see citing works

Hydrogen peroxide release by mitochondria increases during aging

Sohal, R. S., & Sohal, B. H. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90034-w · Cited by 296 · see citing works

Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory event.

Williams, R. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67252-7 · Cited by 273 · see citing works

Nuclear Control of Respiratory Chain Expression in Mammalian Cells

Scarpulla, R. C. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022681828846 · Cited by 269 · see citing works

Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle.

Williams, R. S., Salmons, S., Newsholme, E. A., Kaufman, R. E., & Mellor, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42482-3 · Cited by 268 · see citing works

Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications

Papa, S. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00077-1 · Cited by 264 · see citing works

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

Reis, R. J. S., & Goldstein, S. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44633-3 · Cited by 203 · see citing works

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

Gadaleta, M. N., Rainaldi, G., Lezza, A. M. S., Milella, F., Fracasso, F., & Cantatore, P. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90022-h · Cited by 194 · see citing works

Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle

Pesce, V., Cormio, A., Fracasso, F., Vecchiet, J., Felzani, G., Lezza, A. M. S., Cantatore, P., & Gadaleta, M. N. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00517-2 · Cited by 165 · see citing works

Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging

Barrientos, A., Casademont, J., Cardellach, F., Estivill, X., Urbano-Marquez, A., & Nunes, V. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00278-7 · Cited by 149 · see citing works

Aging‐ and smoking‐associated alteration in the relative content of mitochondrial DNA in human lung

Lee, H., Lu, C.-Y., Fahn, H.-J., & Wei, Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01564-6 · Cited by 147 · see citing works

Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes

Torroni, A., Stepien, G., Hodge, J. A., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30543-4 · Cited by 123 · see citing works

Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP‐Deleted Mitochondrial DNA

Wei, Y., Lee, C., Lee, H., Ma, Y., Wang, C., Lu, C., & Pang, C. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05640.x · Cited by 107 · see citing works

Qualitative and Quantitative Changes in Skeletal Muscle mtDNA and Expression of Mitochondrial-Encoded Genes in the Human Aging Process

Barrientos, A., Casademont, J., Cardellach, F., Ardite, E., Estivill, X., Urbano-Márquez, A., Fernández-Checa, J. C., & Nunes, V. (1997) · Biochemical and Molecular Medicine · doi:10.1006/bmme.1997.2647 · Cited by 86 · see citing works

Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‐1 in skeletal muscle from aged human subjects

Lezza, A. M. S., Pesce, V., Cormio, A., Fracasso, F., Vecchiet, J., Felzani, G., Cantatore, P., & Gadaleta, M. N. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02628-x · Cited by 75 · see citing works

Regulation by thyroid hormone of nuclear and mitochondrial genes encoding subunits of cytochrome-c oxidase in rat liver and skeletal muscle

Wiesner, R. J. (1992) · Molecular Endocrinology · doi:10.1210/me.6.9.1458 · Cited by 63 · see citing works

Increase in Intracellular Hydrogen Peroxide and Upregulation of a Nuclear Respiratory Gene Evoked by Impairment of Mitochondrial Electron Transfer in Human Cells

Suzuki, H., Kumagai, T., Goto, A., & Sugiura, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9181 · Cited by 56 · see citing works

Mitochondrial DNA copy number is proportional to total cell DNA under a variety of growth conditions.

Shay, J. W., Pierce, D. J., & Werbin, H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77184-6 · Cited by 54 · see citing works

Ubisemiquinone radicals from the cytochrome b−c1 complex of the mitochondrial electron transport chain—Demonstration of QP-S radical formation

Wei, Y., Scholes, C. P., & King, T. E. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)90776-2 · Cited by 52 · see citing works

Differential regulation of the transcript levels of some nuclear‐encoded and mitochondrial‐encoded respiratory‐chain components in response to growth activation

Luciaková, K., Ronggui, L. I., & Nelson, B. D. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17045.x · Cited by 49 · see citing works

Content of Mitochondrial DNA and of Three Mitochondrial RNAs in Developing and Adult Rat Cerebellum

Renis, M., Cantatore, P., Polosa, P. L., et al. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb02518.x · Cited by 41 · see citing works

Bladier C, Wolvetang EJ, Hutchinson P, de Haan JB, Kola I. Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis? Cell Growth Differ 8:589–598;1997.

Bladier, C. (1997) · Cell Growth Differ

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Mitochondrial defects in cancer.

Carew, J. S., & Huang, P. (2002) · Molecular Cancer · doi:10.1186/1476-4598-1-9 · Cited by 586 · see citing works

Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging

Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490 · see citing works

Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells

Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works

Inhibition of complex I of the electron transport chain causes O 2 − ·-mediated mitochondrial outgrowth

Koopman, W. J. H., Verkaart, S., Visch, H.-J., van der Westhuizen, F. H., Murphy, M. P., van den Heuvel, L. P., Smeitink, J. A. M., & Willems, P. H. G. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00607.2004 · Cited by 289 · see citing works

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

Müller, M. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2104 · Cited by 237 · see citing works

Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?

Koopman, W. J. H., Verkaart, S., Visch, H.-J., Vries, S. E. V. E., Nijtmans, L. G. J., Smeitink, J. A. M., & Willems, P. H. G. M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00194.2006 · Cited by 132 · see citing works

Estrogen, mitochondria, and growth of cancer and non-cancer cells.

Felty, Q. H., & Roy, D. (2005) · Journal of Carcinogenesis · doi:10.1186/1477-3163-4-1 · Cited by 113 · see citing works

New Insights Into Structure and Function of Mitochondria and Their Role in Aging and Disease

Lenaz, G., Baracca, A., Fato, R., Genova, M. L., & Solaini, G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.417 · Cited by 97 · see citing works

Telomerase and telomeres in aging theory and chronographic aging theory (Review)

Razgonova, M., Zakharenko, A., Golokhvast, K., Thanasoula, M., Sarandi, E., Nikolouzakis, K., Fragkiadaki, P., Tsoukalas, D., Spandidos, D., & Tsatsakis, A. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11274 · Cited by 89 · see citing works

Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism

Weng, S., Lin, T., Liou, C., Chen, S., Wei, Y., Lee, H., Chen, I., Hsieh, C., & Wang, P. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.10.002 · Cited by 62 · see citing works

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., & Wu, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11339 · Cited by 43 · see citing works

Spontaneously Immortalized Mouse Embryo Fibroblasts: Growth Behavior of Wild-Type and Vimentin-Deficient Cells in Relation to Mitochondrial Structure and Activity

Tolstonog, G. V., Belichenko-Weitzmann, I. V., Lu, J., Hartig, R., Shoeman, R. L., Taub, U., & Traub, P. (2005) · DNA and Cell Biology · doi:10.1089/dna.2005.24.680 · Cited by 34 · see citing works

Tissue-specific differences in mitochondrial DNA content in type 2 diabetes

Hsieh, C., Weng, S., Liou, C., Lin, T., Chen, J., Tiao, M., Hung, Y.-T., Chen, I., Huang, W.-T., & Wang, P. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.01.010 · Cited by 32 · see citing works

Mitochondrial Activities of a Cell Line Derived from Thyroid Hürthle Cell Tumors

Stankov, K., Biondi, A., D'Aurelio, M., et al. (2006) · Thyroid · doi:10.1089/thy.2006.16.325 · Cited by 23 · see citing works

The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases

Aparicio‐Trejo, O. E., Cruz, E. Y. H., Reyes-Fermín, L. M., Ceja-Galicia, Z. A., & Pedraza‐Chaverrí, J. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04041-z · Cited by 20 · see citing works

Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: potential molecular targets for cancer therapy

Roy, D. (2006) · Frontiers in bioscience · doi:10.2741/2056 · Cited by 16 · see citing works

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells

Voskamp, C., Anderson, L. A., Koevoet, W., Barnhoorn, S., Mastroberardino, P. G., van Osch, G. J. V. M., & Narcisi, R. (2021) · European Cells and Materials · doi:10.22203/ecm.v042a25 · Cited by 12 · see citing works

Intracellular Glycation of Nuclear DNA, Mitochondrial DNA, and Cytosolic Proteins During Senescence-like Growth Arrest

Breyer, V., Becker, C., & Pischetsrieder, M. (2011) · DNA and Cell Biology · doi:10.1089/dna.2011.1236 · Cited by 11 · see citing works

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging

Zhang, H., Muhetarijiang, M., Chen, R. J., Hu, X., Han, J., Zheng, L., & Chen, T. (2024) · Aging and Disease · doi:10.14336/ad.2024.0058 · Cited by 11 · see citing works

Stability and Association with the Cytomatrix of Mitochondrial DNA in Spontaneously Immortalized Mouse Embryo Fibroblasts Containing or Lacking the Intermediate Filament Protein Vimentin

Bannikova, S. V., Zorov, D. B., Shoeman, R. L., Tolstonog, G. V., & Traub, P. (2005) · DNA and Cell Biology · doi:10.1089/dna.2005.24.710 · Cited by 10 · see citing works

Peripheral blood leukocyte mitochondrial DNA content and risk of lung cancer

Kennedy, G. T., Mitra, N., Penning, T. M., Whitehead, A. S., & Vachani, A. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-979 · Cited by 6 · see citing works

Rejuvenation on the Road to Pluripotency

Sarkar, T. J., & Sebastiano, V. (2016) · InTech eBooks · doi:10.5772/63219 · Cited by 2 · see citing works

Redox regulation in pulmonary fibrosis

Veith (2019) · doi:10.26481/dis.20190524cv · Cited by 1 · see citing works

4-Hydroxy Estradiol-Induced Oxidant-Mediated Signaling Is Involved In The Development Of Breast Cancer

Okoh, V. O. (2010) · doi:10.25148/etd.fi11041501

The influence of aging on oocyte quality and the importance of mitochondria

Trull, K. (2014) · doi:10.17760/d20005089

Investigation of Mitochondrial Transfer between Human Erythroblasts

Lewer, B. (2019) · doi:10.26686/wgtn.17138759

Mitochondrial proteins and colorectal cancer risk: A mendelian randomization study

Wu, D., Tong, D., Gao, M., Zhang, X., & Hu, X. (2024) · doi:10.52768/jjgastro/1197

Two modes of mitochondrial DNA transmission in mice: Maternal inheritance and rapid segregation

Shitara, H., & Yonekawa, H. (2011) · PLANT MORPHOLOGY · doi:10.5685/plmorphol.23.35 · Cited by 1 · see citing works

Initiation, Progression, and Genetic Manipulation of Leaf Senescence

Ali, A. A., Gao, X., & Guo, Y. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7672-0_2 · Cited by 27 · see citing works

Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes

Lee, R., Wang, C., Huang, L., et al. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.358.1117 · Cited by 195 · see citing works

Brassinosteroids and Senescence

Çağ, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-6058-9_6 · Cited by 3 · see citing works

Gene expression during leaf senescence

Smart, C. M. (1994) · New Phytologist · doi:10.1111/j.1469-8137.1994.tb04243.x · Cited by 708 · see citing works