Cited by 236Advanced Drug Delivery SystemsGlycosylation and Glycoproteins ResearchInhalation and Respiratory Drug Delivery

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Lectin-mediated mucosal delivery of drugs and microparticles

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Clark, M.Ann, Hirst, Barry H, Jepson, Mark A·2000·Advanced Drug Delivery Reviews

DOI 10.1016/s0169-409x(00)00070-3

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Abstract

Absorption of drugs and vaccines at mucosal surfaces may be enhanced by conjugation to appropriate bioadhesins which bind to mucosal epithelia. Bioadhesins might also permit cell- and site-selective targeting. One approach is to exploit surface carbohydrates on mucosal epithelial cells for lectin-mediated delivery. We review work supporting the use of lectins as mucosal bioadhesins in the gastrointestinal and respiratory tracts, the oral cavity and the eye. The gastrointestinal tract is particularly favoured for mucosal delivery. Many studies have demonstrated that the antigen sampling intestinal M cells offer a portal for absorption of colloidal delivery vehicles. Evidence is presented that M cell targeting may be achieved using M cell-specific lectins, microbial adhesins or immunoglobulins. While many hurdles must be overcome before mucosal bioadhesins can guarantee consistent, safe, effective mucosal delivery, this is an exciting area of research that has important implications for future drug and vaccine formulation.

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Authors: Clark, M. A., Hirst, B. H., & Jepson, M. A.
Affiliations: Newcastle University (GB)
University of Bristol (GB)
Corresponding author: Jepson, Mark A
ORCID: Hirst, Barry H
Jepson, Mark A
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2000-09
Volume: 43
Issue: 2-3
Pages: 207-223
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/s0169-409x(00)00070-3
OpenAlex: W2063013932
Cited by: 236
References: 121
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 14 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 17
FWCI: 1.41
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: lectins, mucosal drug delivery, M cells, intestinal mucosa, respiratory mucosa, oral mucosa, ocular drug delivery, microparticles, colloidal drug delivery, vaccine delivery, gastrointestinal tract
MeSH terms: Animals, Gastric Mucosa, Humans, Intestinal Absorption, Intestinal Mucosa, Nasal Mucosa, Vaccines, Drug Delivery Systems, Lectins

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Lectin-mediated mucosal delivery of drugs and microparticles

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