The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Lectin-mediated mucosal delivery of drugs and microparticles
Open accessAbstract
Absorption of drugs and vaccines at mucosal surfaces may be enhanced by conjugation to appropriate bioadhesins which bind to mucosal epithelia. Bioadhesins might also permit cell- and site-selective targeting. One approach is to exploit surface carbohydrates on mucosal epithelial cells for lectin-mediated delivery. We review work supporting the use of lectins as mucosal bioadhesins in the gastrointestinal and respiratory tracts, the oral cavity and the eye. The gastrointestinal tract is particularly favoured for mucosal delivery. Many studies have demonstrated that the antigen sampling intestinal M cells offer a portal for absorption of colloidal delivery vehicles. Evidence is presented that M cell targeting may be achieved using M cell-specific lectins, microbial adhesins or immunoglobulins. While many hurdles must be overcome before mucosal bioadhesins can guarantee consistent, safe, effective mucosal delivery, this is an exciting area of research that has important implications for future drug and vaccine formulation.
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“lectins are often toxic and susceptible to proteolytic degradation in the GI tract, which renders some of them inappropriate for in vivo application [105,117].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [105]
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Metadata
- Authors
- Clark, M. A., Hirst, B. H., & Jepson, M. A.
- Affiliations
- Newcastle University (GB)
- University of Bristol (GB)
- Corresponding author
- Jepson, Mark A
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 43
- Issue
- 2-3
- Pages
- 207-223
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2063013932
- Cited by
- 236
- References
- 121
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 14 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 17
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- lectins, mucosal drug delivery, M cells, intestinal mucosa, respiratory mucosa, oral mucosa, ocular drug delivery, microparticles, colloidal drug delivery, vaccine delivery, gastrointestinal tract
- MeSH terms
- Animals, Gastric Mucosa, Humans, Intestinal Absorption, Intestinal Mucosa, Nasal Mucosa, Vaccines, Drug Delivery Systems, Lectins
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