The DOI matches its Crossref record; 246 of the 255 references it cites were found in a registry or an index.
Nasal mucociliary clearance as a factor in nasal drug delivery
Abstract
The nasal mucociliary clearance system transports the mucus layer that covers the nasal epithelium towards the nasopharynx by ciliary beating. Its function is to protect the respiratory system from damage by inhaled substances. Impairment of nasal mucociliary clearance can result in diseases of the upper airways. Therefore, it is important to study the effects of drugs and drug excipients on nasal mucociliary clearance. A large number of methods are used to assess mucociliary clearance. These methods study the effects of drug and excipients on the mucociliary system in vitro or in vivo in animals and humans. In some cases, the results of different in vitro and in vivo measurements do not correlate well. In vitro methods, especially ciliary beat frequency measurements, have been demonstrated to be valuable tools for toxicity screening. However, in vivo studies are essential to confirm the safety of nasal drug formulations. Nasal mucociliary clearance also has implications for nasal drug absorption. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in fast systemic drug absorption. Several approaches are discussed to increase the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. However, more experimental evidence is needed to support the conclusion that this improved absorption is caused by a longer residence time of the nasal drug formulation.
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“Samples taken from 30 minutes onwards, however, cannot reflect spiking, as substances that are not absorbed across the nasal membrane are transported to the back of the throat, and then swallowed within 15 minutes [14].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [14]
In the citing paper
“Hence, taking saliva samples at 15 minutes creates the risk of collecting saliva that is ‘spiked’ with IN-OT (indeed this may be why other saliva studies have chosen 30 minutes as their first measurement, as this allows almost double the length of time of average mucociliary transport [14]).”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [14]
In the citing paper
“This process of clearing substances from the nasal cavity to the back of the throat, called mucociliary transport, takes 12–15 minutes in healthy individuals [14].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [14]
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“Such factors make the nasal cavity an attractive route for drug delivery, but they also result in nasal mucosa cells being vulnerable to adverse effects of drugs and excipients delivered intranasally ([102].”
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“There have been a lot of developments of drug delivery systems based on CDs, which were used in nasal drug delivery [16–18], in peptide and protein delivery [19], in ophthalmic drug delivery [20], and in many other areas [21–27].”
BackgroundEvaluation of intranasal delivery route of drug administration for brain targeting
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Pires, A., Fortuna, A., Alves, G., & Falcão, A. (2009) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3nc79 · Cited by 641
Metadata
- Authors
- Marttin, E., Schipper, N. G. M., Verhoef, J. C., & Merkus, F. W. H. M.
- Corresponding author
- Merkus, Frans W.H.M
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 29
- Issue
- 1-2
- Pages
- 13-38
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2089895093
- Cited by
- 469
- References
- 255
- Citations by year
- 2026: 24 · 2025: 45 · 2024: 26 · 2023: 40 · 2022: 32 · 2021: 34 · 2020: 26 · 2019: 16 · 2018: 27 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 24 · 2013: 17 · 2012: 15
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Keywords
- nasal mucociliary clearance, intranasal drug delivery, ciliary beat frequency, mucus transport, pharmaceutical excipients, nasal drug absorption, residence time, toxicity screening, upper airway diseases, in vitro-in vivo correlation
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