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Materials for protein delivery in tissue engineering
Open accessAbstract
The ability of protein agents to modulate cellular behaviors, such as motility, proliferation, adhesion and function, is the subject of intense research; new therapies involving proteins will likely result. Unfortunately, many proteins have short half-lives and the potential for toxicity after systemic delivery, so traditional routes of administration are not appropriate. Alternate methods for sustained delivery of these agents to the desired cells and tissues in biologically active conformations and concentrations are necessary. Techniques similar to those long used in the controlled delivery of drugs have been used to administer certain growth factors to cells and tissues; although clinical success has been limited to date, studies in animal models suggest the potential for tremendous advances in the near future. This review outlines the basic technology of controlled protein delivery using polymeric materials, and discusses some of the techniques under investigation for the efficient administration of proteins in tissue engineering.
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Cites
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Self-citation
Cited by
Polymeric biomaterials for tissue and organ regeneration
Seal, B. (2001) · Materials Science and Engineering: R: Reports · doi:10.1016/s0927-796x(01)00035-3 · Cited by 892
Qi, H., Hu, P., Xu, J., & Wang, A. (2006) · Biomacromolecules · doi:10.1021/bm060264z · Cited by 323
Shape‐memory polymer networks from oligo(ϵ‐caprolactone)dimethacrylates
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Metadata
- Authors
- Baldwin, S. P., & Mark Saltzman, W.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 33
- Issue
- 1-2
- Pages
- 71-86
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2026873403
- Cited by
- 243
- References
- 5
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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