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Cited by 47Influenza Virus Research StudiesEar Surgery and Otitis MediaGlycosylation and Glycoproteins Research

Effects of influenza A virus on lectin-binding patterns in murine nasopharyngeal mucosa and on bacterial colonization

Hirano, Takashi, Kurono, Yuichi, Ichimiya, Issei, Suzuki, Masashi, Mogi, Goro·1999·Otolaryngology–Head and Neck Surgery
DOI 10.1016/s0194-5998(99)70068-9
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Abstract

To clarify the role of viral infection in otitis media, we intranasally inoculated mice with influenza A virus and examined histologic changes in the nasopharyngeal mucosa using a battery of lectins. Additionally, live Haemophilus influenzae or Streptococcus pneumoniae was injected into the nasopharynx after virus inoculation, and the clearance of bacteria from the nasopharynx was examined. Staining of the mucous blanket and epithelial cell surfaces in the nasopharynx with peanut agglutinin, succinyl wheat-germ agglutinin, and Bandeiraea simplicifolia agglutinin was significantly enhanced with intranasal virus inoculation when compared with that in control animals. The nasopharynx was moderately stained with Maachia amurensis agglutinin and wheat-germ agglutinin in control animals, and the staining was enhanced after virus inoculation. These findings were most remarkable 5 and 9 days after virus inoculation. The numbers of bacteria cultured from the nasopharynx were significantly increased when bacteria were injected 5 days after virus inoculation. These results suggest that an alteration in the glycoconjugate structure lining the nasopharyngeal mucosa caused by the influenza virus might be associated with the reduction in bacterial clearance.

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Crossref · 10.1016/s0194-5998(99)70068-9

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  • In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT, including S. pneumoniae and H. influenzae.

    “In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT (90–95), including S. pneumoniae and H. influenzae (86–88).”

    From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [90]

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Authors
Hirano, T., Kurono, Y., Ichimiya, I., Suzuki, M., & Mogi, G.
Affiliations
Department of Otolaryngology Oita Medical University Oita Japan
ORCID
Venue
Otolaryngology–Head and Neck Surgery
Publisher
Wiley
Published
1999-11
Volume
121
Issue
5
Pages
616-621
ISSN
  • 0161-6439 (ISSN-L)
  • 0194-5998
  • 1097-6817
DOI
10.1016/s0194-5998(99)70068-9
OpenAlex
W2015525633
Cited by
47
References
22
Citations by year
2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 1 · 2012: 3
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6042 d)
Locations
  • Otolaryngology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Otorhinolaryngology › Ear Surgery and Otitis Media
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords
influenza A virus, lectin binding, nasopharyngeal mucosa, glycoconjugates, bacterial colonization, Haemophilus influenzae, Streptococcus pneumoniae, bacterial clearance, otitis media, viral infection
MeSH terms
Animals, Bacterial Infections, Haemophilus influenzae, Male, Mice, Inbred BALB C, Microscopy, Electron, Mucociliary Clearance, Nasal Mucosa, Nasopharynx, Orthomyxoviridae Infections, Influenza A virus, Receptors, Mitogen, Streptococcus pneumoniae, Colony Count, Microbial, Mice

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