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Cited by 231Pneumonia and Respiratory InfectionsInfluenza Virus Research StudiesMicrobial infections and disease research

Adherence of Type I Streptococcus pneumoniae to Tracheal Epithelium of Mice Infected with Influenza A/PR8 Virus

Plotkowski, Maria-Cristina, Puchelle, Edith, Beck, Geneviève, Jacquot, Jacky, Hannoun, Claude·1986·American Review of Respiratory Disease
DOI 10.1164/arrd.1986.134.5.1040
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Abstract

Bacterial adherence to virus-infected respiratory tract cells may be one of the several mechanisms whereby virus predisposes to bacterial pneumonia. To evaluate the effect of influenza virus infection on pneumococcus adhesion, 39 mice were infected with PR8/A influenza virus. The adherence of radiolabeled pneumococcus to mice tracheal cells was determined 2, 4, and 6 days after viral inoculation. The pneumococcal adhesion to infected tracheas was significantly enhanced on Day 6 (p less than 0.001). Scanning and transmission electron microscopy revealed that by the fourth and sixth days after virus inoculation, the ciliated and the secretory cells of the tracheal epithelium had desquamated and the mucosa were coated with a continuous layer of basal cells. In a few cases, a desquamation of the basal layer was observed and the exposed basement membrane appeared as a pole of attraction for bacteria. Pneumococci were never seen attached to control tracheas. In contrast, they were observed adhered to the microvilli of the basal cells and, to a greater extent, to the exposed basement membrane.

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Crossref · 10.1164/arrd.1986.134.5.1040

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Expression of hBD-2 and hBD-3, but not that of hBD-1, is induced in bronchial epithelial cells after rhinovirus infection.

    “Accordingly, expression of hBD-2 and hBD-3, but not that of hBD-1, is induced in bronchial epithelial cells after rhinovirus infection (55, 218).”

    From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [218]

  • In mice infected with influenza, colonization and adherence of S. pneumoniae to tracheal cells is enhanced.

    “Plotkowski et al. (1986) found enhanced colonization and adherence of S. pneumoniae to the tracheal cells of mice when they were infected with influenza (Plotkowski et al., 1986).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Plotkowski et al., 1986

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Authors
Plotkowski, M.-C., Puchelle, E., Beck, G., Jacquot, J., & Hannoun, C.
ORCID
Jacquot, Jacky
Venue
American Review of Respiratory Disease
Publisher
Oxford University Press (OUP)
Published
1986-11-01
Volume
134
Issue
5
Pages
1040-1044
ISSN
0003-0805 (ISSN-L)
DOI
10.1164/arrd.1986.134.5.1040
OpenAlex
W1918510262
Cited by
231
References
31
Citations by year
2026: 5 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 12 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 13 · 2012: 4
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Review of Respiratory Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
Streptococcus pneumoniae, bacterial adhesion, influenza A virus, PR8 strain, tracheal epithelium, viral-bacterial coinfection, bacterial pneumonia, epithelial desquamation, basement membrane, ciliated cells, secretory cells, basal cells, microvilli, respiratory tract
MeSH terms
Animals, Bacterial Adhesion, Epithelium, Male, Microscopy, Electron, Microscopy, Electron, Scanning, Orthomyxoviridae Infections, Influenza A virus, Streptococcus pneumoniae, Trachea, Mice

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