The effects of acute and chronic alpha melanocyte stimulating hormone (αMSH) on cardiovascular dynamics in conscious rats
Abstract
Alpha melanocyte stimulating hormone (alphaMSH) has been demonstrated to have regulatory functions in the periphery and central nervous system (CNS). alphaMSH plays a central role in the regulation of metabolic balance such as decreasing food intake, increasing sympathetic outflow and hypothalamic/pituitary function. Our laboratory has investigated the actions of alphaMSH on sympathetic and cardiovascular dynamics using anesthetized animals. In this study we determined both the acute and chronic effects of alphaMSH on cardiovascular and metabolic dynamics in conscious unrestrained rats. Animals were each implanted with a radio-telemetry transmitter for recording of cardiovascular parameters and subsequently instrumented with intracerebroventricular (ICV) cannulas. The acute ICV administration of alphaMSH significantly increased the mean arterial pressure (MAP) and heart rate (HR) when compared to artificial cerebrospinal fluid (ACSF) controls. On the other hand chronic alphaMSH infusion resulted in an initial increase in MAP and HR lasting for 2 days followed by a decrease in MAP. Chronic alphaMSH administration decreased physical activity and food intake but not weight gain. We conclude that in the conscious unrestrained animal the acute administration of alphaMSH increased MAP and HR, however, chronic infusion is associated with decreased MAP, physical activity and food intake.
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The effects of α-MSH on blood pressure are mediated mainly by direct actions on the central nervous system since intravenous injections of α-MSH have no measurable effect on blood pressure.
“The effects of α-MSH on BP are mediated mainly by direct actions on the CNS since i.v. injections of α-MSH have no measureable effect on BP [23, 24].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [24]
Acute intracerebroventricular injections of α-MSH increase sympathetic nervous system activity and blood pressure.
“Several previous studies have shown that acute ICV injections of α-MSH increase SNS activity and BP [19, 23, 24].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [24]
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- Authors
- Hill, C., & Dunbar, J. C.
- Affiliations
- Wayne State University (US)
- Corresponding author
- Dunbar, Joseph C
- ORCID
- Dunbar, Joseph C
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 23
- Issue
- 9
- Pages
- 1625-1630
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2067355988
- Cited by
- 34
- References
- 19
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R25GM058905, GM58905-04)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- alpha-melanocyte-stimulating hormone, cardiovascular dynamics, mean arterial pressure, heart rate, sympathetic nervous system, intracerebroventricular administration, chronic infusion, dietary intake, physical activity, metabolic regulation, conscious unrestrained rats
- MeSH terms
- alpha-MSH, Animals, Blood Pressure, Cardiovascular System, Heart Rate, Male, Telemetry, Time Factors, Rats, Wistar, Rats
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