Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function

Nicholson, J. R.; Peter, J.‐C.; Lecourt, A.‐C.; Barde, Y.‐A.; Hofbauer, K. G.

doi:10.1111/j.1365-2826.2007.01610.x

Cited by 88Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function

Nicholson, J. R., Peter, J.‐C., Lecourt, A.‐C., Barde, Y.‐A., Hofbauer, K. G.·2007·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2007.01610.x

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Abstract

In the present study, we aimed to investigate the neuromodulatory role played by hypothalamic brain-derived neurotrophic factor (BDNF) in the regulation of acute cardiovascular and feeding responses to melanocortin-4 receptor (MC4R) activation. In vitro, a selective MC4R agonist, MK1, stimulated BDNF release from isolated rat hypothalami and this effect was blocked by preincubation with the MC3/4R antagonist SHU-9119. In vivo, peripheral administration of MK1 decreased food intake in rats and this effect was blocked by pretreatment with an anti-BDNF antibody administered into the third ventricle. When anorexia was induced with the cannabinoid-1 receptor (CB1R) antagonist AM251, the anti-BDNF antibody did not prevent the reduction in food intake. Peripheral administration of MK1 also increased mean arterial pressure, heart rate and body temperature. These effects were prevented by pretreatment with the anti-BDNF antibody whereas the intracerebroventricular administration of BDNF caused changes similar to those of MK1. These findings demonstrate for the first time that activation of MC4R leads to an acute release of BDNF in the hypothalamus. This release is a prerequisite for MC4R-induced effects on appetite, body temperature and cardiovascular function. By contrast, CB1R antagonist-mediated anorexia is independent of the MC4R/BDNF pathway. Overall, these results show that BDNF is an important downstream mediator of the MC4R pathway.

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Mutations of the POMC gene or the MC4R are estimated to account for as much as 5-6% of early onset obesity in humans.
“Mutations of the POMC gene or the MC4R are estimated to account for as much as 5–6% of early onset obesity in humans (48, 64).”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [64]
The reduction in 24-hour food intake and increase in blood pressure caused by the MC4R agonist MK1 was reduced by prior central injection of an anti-BDNF antibody.
“Nicholson and colleagues also found that the reduction in 24-hour food intake and increase in BP caused by the MC4R agonist, MK1, was reduced by prior central injection of an anti-BDNF antibody [64].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [64]

Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778 · see citing works
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157 · see citing works
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience · doi:10.1038/nn1073 · Cited by 896 · see citing works
Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0706 · Cited by 781 · see citing works
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
Yeo, G. S. H., Hung, C.-C. C., Rochford, J. J., Keogh, J. M., Gray, J. A., Sivaramakrishnan, S., O’Rahilly, S., & Farooqi, I. S. (2004) · Nature Neuroscience · doi:10.1038/nn1336 · Cited by 608 · see citing works
Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene
Gray, J. A., Yeo, G. S. H., Cox, J. J., Morton, J., Adlam, A., Keogh, J. M., Yanovski, J. A., Gharbawy, A. E., Han, J. C., Tung, Y. C. L., et al. (2006) · Diabetes · doi:10.2337/db06-0550 · Cited by 515 · see citing works
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
King, B. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.10.007 · Cited by 490 · see citing works
CNS origins of the sympathetic nervous system outflow to brown adipose tissue
Bamshad, M., Song, C. K., & Bartness, T. J. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.6.r1569 · Cited by 437 · see citing works
Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons
Bałkowiec, A., & Katz, D. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10399.2002 · Cited by 405 · see citing works
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
Fan, W., Ellacott, K. L. J., Halatchev, I. G., Takahashi, K. A., Yu, P., & Cone, R. D. (2004) · Nature Neuroscience · doi:10.1038/nn1214 · Cited by 306 · see citing works
Evaluation and applications of radiotelemetry in small laboratory animals
Kramer, K., & Kinter, L. B. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00164.2002 · Cited by 224 · see citing works
Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview
Lebrun, B., Bariohay, B., Moyse, E., & Jean, A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.027 · Cited by 219 · see citing works
Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist
Sebhat, I. K., Martin, W. J., Ye, Z., Barakat, K., Mosley, R. T., Johnston, D. B. R., Bakshi, R. K., Palucki, B. L., Weinberg, D. H., MacNeil, T., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025539h · Cited by 194 · see citing works
Brain-Derived Neurotrophic Factor Plays a Role as an Anorexigenic Factor in the Dorsal Vagal Complex
Bariohay, B., Lebrun, B., Moyse, E., & Jean, A. (2005) · Endocrinology · doi:10.1210/en.2005-0419 · Cited by 162 · see citing works
Brain‐Derived Neurotrophic Factor Levels in the Nervous System of Wild‐Type and Neurotrophin Gene Mutant Mice
Kolbeck, R., Bartke, I., Eberle, W., & Barde, Y. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721930.x · Cited by 141 · see citing works
A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor
Yang, B. K., Slonimsky, J. D., & Birren, S. J. (2002) · Nature Neuroscience · doi:10.1038/nn0602-853 · Cited by 137 · see citing works
Regulation of Melanocortin-4 Receptor Signaling: Agonist-Mediated Desensitization and Internalization
Shinyama, H., Masuzaki, H., Fang, H., & Flier, J. S. (2003) · Endocrinology · doi:10.1210/en.2002-220931 · Cited by 136 · see citing works
Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
Komori, T., Morikawa, Y., Nanjo, K., & Senba, E. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.066 · Cited by 122 · see citing works
Sympathetic nerve activity after discrete hypothalamic injections of l-glutamate
Yoshimatsu, H., Egawa, M., & Bray, G. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)91702-t · Cited by 102 · see citing works
Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake
Wang, C., Bomberg, E. M., Levine, A. S., Billington, C. J., & Kotz, C. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00125.2007 · Cited by 99 · see citing works
The role of the endocannabinoid system in the control of energy homeostasis
Osei‐Hyiaman, D., Harvey-White, J. D., Bátkai, S., & Kunos, G. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803276 · Cited by 93 · see citing works
Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic–pituitary–adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats
Naert, G., IXART, G., Tapia‐Arancibia, L., & Givalois, L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.028 · Cited by 90 · see citing works
Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones
Ni, X.-P., Butler, A. A., Cone, R. D., & Humphreys, M. H. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000249702.49854.fa · Cited by 88 · see citing works
Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice
Tsuchida, A., Nonomura, T., Ono‐Kishino, M., Nakagawa, T., Taiji, M., & Noguchi, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801678 · Cited by 86 · see citing works
AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion
Chambers, A. P., Koopmans, H. S., Pittman, Q. J., & Sharkey, K. A. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706439 · Cited by 68 · see citing works
Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat
Murphy, B. A., Nunes, C. N., Ronan, J. J., Hanaway, M., Fairhurst, A., & Mellin, T. N. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.273 · Cited by 68 · see citing works
Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake
Verty, A. N. A., McFarlane, J. R., McGregor, I. S., & Mallet, P. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.002 · Cited by 62 · see citing works
The Leptin-Like Effects of 3-d Peripheral Administration of a Melanocortin Agonist Are More Marked in Genetically Obese Zucker (fa/fa) than in Lean Rats
Cettour-Rose, P., & Rohner‐Jeanrenaud, F. (2002) · Endocrinology · doi:10.1210/endo.143.6.8871 · Cited by 53 · see citing works
Effects of cholecystokinin on sympathetic activity to interscapular brown adipose tissue
Yoshimatsu, H., Egawa, M., & Bray, G. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)91486-x · Cited by 47 · see citing works
Injection of brain-derived neurotrophic factor in the rostral ventrolateral medulla increases arterial blood pressure in anaesthetized rats
Wang, H. H., & Zhou, X. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00085-4 · Cited by 41 · see citing works
The effects of acute and chronic alpha melanocyte stimulating hormone (αMSH) on cardiovascular dynamics in conscious rats
Hill, C., & Dunbar, J. C. (2002) · Peptides · doi:10.1016/s0196-9781(02)00103-1 · Cited by 34 · see citing works
Cardiovascular responses to melanocortin 4-receptor stimulation in conscious unrestrained normotensive rats
Nordheim, U., Nicholson, J. R., Dokładny, K., Dunant, P., & Hofbauer, K. G. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.026 · Cited by 23 · see citing works
α-Melanocyte-stimulating hormone (MSH) and [Nle4, D-Phe7]-α-MSH: Effects on core temperature in rats
Raible, L. H., & Knickerbocker, D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90163-n · Cited by 18 · see citing works

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Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants
Hohenadel, M. G., Thearle, M. S., Grice, B. A., Huang, H., Dai, M.-H., Tao, Y.-X., Hunter, L. A., Palaguachi, G. I., Mou, Z., Kim, R. C., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.221 · Cited by 20 · see citing works
Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto–Kakizaki rats
Maekawa, F., Fujiwara, K., Toriya, M., Maejima, Y., Nishio, T., Toyoda, Y., Nohara, K., Yashiro, T., & Yada, T. (2013) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2013.00007 · Cited by 19 · see citing works
Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study
Smith, A. J., Malan, L., Uys, L., Malan, N. T., Harvey, B. H., & Ziemssen, T. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.39 · Cited by 19 · see citing works
MC4R in Central and Peripheral Systems
Wei, R., Li, D., Jia, S., Chen, Y., & Wang, J. (2023) · Advanced Biology · doi:10.1002/adbi.202300035 · Cited by 18 · see citing works
Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats
de Moraes, R. C. M., Lima, G. C. A., Cardinali, C. A. E. F., de Gonçalves, A. C., Portari, G. V., Guerra‐Shinohara, E. M., Leboucher, A., Donato, J., Kleinridders, A., & Torrão, A. D. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120841 · Cited by 16 · see citing works
Melanocortin MC4 receptor-mediated feeding and grooming in rodents
Mul, J. D., Spruijt, B. M., Brakkee, J. H., & Adan, R. A. H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.060 · Cited by 14 · see citing works
Activation of Melanocortin-4 Receptor Inhibits Both Neuroinflammation Induced by Early Exposure to Ethanol and Subsequent Voluntary Alcohol Intake in Adulthood in Animal Models: Is BDNF the Key Mediator?
Flores-Bastías, O., Adriasola-Carrasco, A. A., & Karahanian, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00005 · Cited by 14 · see citing works
The Melanocortin System: A Promising Target for the Development of New Antidepressant Drugs
Markov, D. D., Dolotov, O. V., & Grivennikov, I. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076664 · Cited by 14 · see citing works
Substitution of Arginine with Proline and Proline Derivatives in Melanocyte-Stimulating Hormones Leads to Selectivity for Human Melanocortin 4 Receptor
Qu, H., Cai, M., Mayorov, A. V., Grieco, P., Zingsheim, M. R., Trivedi, D. B., & Hruby, V. J. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801300c · Cited by 13 · see citing works
Central alpha-MSH, energy balance, thermal balance, and antipyresis
Balaskó, M., Garami, A., Soós, S., Koncsecskó-Gáspár, M., Székely, M., & Pétervári, E. (2010) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2010.05.003 · Cited by 12 · see citing works
Brain-derived neurotrophic factor (BDNF) affects somatotrophic axis activity in sheep
Przybył, B., Wójcik-Gładysz, A., Gajewska, A., & Szlis, M. (2021) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/143353/2021 · Cited by 12 · see citing works
A common variant near BDNF is associated with dietary calcium intake in adolescents
Dušátková, L., Zamrazilová, H., Aldhoon-Hainerová, I., Sedláčková, B., Včelák, J., Hlavatý, P., Bendlová, B., Kunešová, M., & Hainer, V. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.06.004 · Cited by 12 · see citing works
Modulation of Neurotrophin Signaling by Monoclonal Antibodies
Rosenthal, A., & Lin, J. C. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-45106-5_19 · Cited by 12 · see citing works
Predisposition of the Common MC4R rs17782313 Female Carriers to Elevated Obesity and Interaction with Eating Habits
Chermon, D., & Birk, R. Z. (2023) · Genes · doi:10.3390/genes14111996 · Cited by 12 · see citing works
Association of Adenovirus 36 Infection With Obesity-Related Gene Variants in Adolescents
Dušátková, L., Zamrazilová, H., Hainerová, I. A., Atkinson, R. L., Sedláčková, B., Lee, Z. P., Včelák, J., Bendlová, B., Kunešová, M., & Hainer, V. (2015) · Physiological Research · doi:10.33549/physiolres.933131 · Cited by 10 · see citing works
Melanocortin-4 Receptor (MC4R) gene polymorphism and its effect on growth traits in Madura cattle
Prihandini, P. W., Sumadi, S., Suparta, G., & Maharani, D. (2019) · Journal of the Indonesian Tropical Animal Agriculture · doi:10.14710/jitaa.44.1.38-46 · Cited by 10 · see citing works
The BDNF Val66Met polymorphism serves as a potential marker of body weight in patients with psychiatric disorders
Zhang, Y., Wei, X., Zhang, W., Jin, F., Cao, W., Yue, M., & Mo, S. (2024) · AIMS neuroscience · doi:10.3934/neuroscience.2024012 · Cited by 9 · see citing works
The Nutritional Induction of COUP-TFII Gene Expression in Ventromedial Hypothalamic Neurons Is Mediated by the Melanocortin Pathway
Sabra-Makke, L., Tourrel‐Cuzin, C., Denis, R., Moldes, M., Pégorier, J. P., Luquet, S. H., Vasseur-Cognet, M., & Bossard, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013464 · Cited by 8 · see citing works
Brain-Derived Neurotrophic Factor Affects mRNA and miRNA Expression of the Appetite Regulating Centre in the Sheep Arcuate Nucleus
Przybył, B. J., Szlis, M., & Wójcik-Gładysz, A. (2020) · Annals of Animal Science · doi:10.2478/aoas-2020-0015 · Cited by 7 · see citing works
The Hypothalamus and Its Functions
Zoccoli, G., Amici, R., & Silvani, A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8390-9_17 · Cited by 7 · see citing works
Feeding signals to the hungry mind
Balthasar, N. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2008.042226 · Cited by 7 · see citing works
The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats
Hasegawa, Y., Takemoto, Y., Hayashi, K., Kameno, K., & Kim‐Mitsuyama, S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111286 · Cited by 6 · see citing works
Acute exposure to an electric field induces changes in human plasma 9-HODE, 13-HODE, and immunoreactive substance P levels: Insight into the molecular mechanisms of electric field therapy
Nakagawa-Yagi, Y., Hara, H., Nakagawa, F., Sato, M., & Hara, A. (2016) · Integrative Molecular Medicine · doi:10.15761/imm.1000210 · Cited by 6 · see citing works
Anti-trkb Antibodies as Pharmacological Tools to Study the Function of the Trkb Receptor and its Role in the Regulation of Food Intake
Peter, J., Zipfel, G., Rossez, H., Weckering, M., Lecourt, A.-C., & Hofbauer, K. G. (2012) · Pharmacologia · doi:10.5567/pharmacologia.2013.1.14 · Cited by 5 · see citing works
Regulation of the Intracerebroventricular Administration of Brain-Derived Neurotrophic Factor on Baroreflex Function and Insulin Sensitivity in Rats
Wang, M.-F. (2012) · The Chinese Journal of Physiology · doi:10.4077/cjp.2012.baa015 · Cited by 4 · see citing works
Neuroanatomical evidence of the melanocortin-4 receptor expression in the mesencephalic periaqueductal gray innervating renal tissues.
Ke, Q.-F., & Wang, L. (2015) · PubMed Central · Cited by 4 · see citing works
Medical Therapy for Obesity
Dayyeh, B. K. A., & Kaplan, L. M. (2011) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2011.02.006 · Cited by 4 · see citing works
Cardiovascular Neuroendocrinology
Yosten, G. L. C., & Samson, W. K. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10013-7 · Cited by 4 · see citing works
Brain-derived neurotrophic factor : generation and characterization of adult mice lacking BDNF in the adult brain
Rauskolb, S. (2008) · edoc (University of Basel) · doi:10.5451/unibas-004587325 · Cited by 4 · see citing works
Hypothalamic gene transfer of BDNF promotes healthy aging
Cao, L., Ali, S., & Queen, N. J. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.003 · Cited by 3 · see citing works
The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases
Chaldakov, G. N., Aloe, L., Rančić, G., Pancheva, R., Hiriart, M., Fiore, M., & Yanev, S. G. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-84763-0_16 · Cited by 2 · see citing works
Polyunsaturated fatty acids in cancer and their influence on biochemical and metabolic events and body composition
Das, U. N. (2014) · Nutrition · doi:10.1016/j.nut.2014.12.003 · Cited by 2 · see citing works
A Growing Journey From Neurotrophins To Metabotrophins In Cardiometabolic Diseases
Aloe, L., Vinciguerra, M., Tonchev, A. B., Fiore, M., Deleva, N. S., Fröhlich, J., & Chaldakov, G. N. (2021) · Adipobiology · doi:10.14748/adipo.v11.8558 · Cited by 1 · see citing works
Environmental Enrichment Normalizes Metabolic Function in the Murine Model of Prader–Willi Syndrome Magel2-Null Mice
Queen, N. J., Zou, X., Huang, W., Mohammed, T., & Cao, L. (2025) · Endocrinology · doi:10.1210/endocr/bqaf001 · Cited by 1 · see citing works
Submandibular glands in the metabolic syndrome
Hristova, M. G., Chaushev, B. G., Klisarova, A. D., & Kovacheva, T. (2007) · Biomedical Reviews · doi:10.14748/bmr.v18.69 · Cited by 1 · see citing works
Effects of pituitary pars intermedia dysfunction (PPID), season, and pasture diet on blood adrenocorticotropic hormone and metabolite concentrations in horses.
Elliott, S. B. (2010) · Cited by 1 · see citing works
Le récepteur 4 aux mélanocortines, un paradigme de la génétique de l'obésité
Stutzmann, F. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Hypothalamic Melanocortin Regulation of Energy Balance and Metabolism
Dutia, R. (2012) · doi:10.7916/d85b00j6
Molekulare Charakterisierung an der hypothalamischen Appetitregulation beteiligter Rezeptoren
Fakultät, D. D. M.-N., & Schön, L.-H. (2008)
Genetische Mechanismen der Gewichtsregulation: genomweite Ansätze und Kandidatengenstudien
Friedel, S. (2009) · Common Library Network (Der Gemeinsame Bibliotheksverbund)
Nutritional regulation of central fat mass and obesity-associated (FTO) expression, and its association with the central melanocortin signaling in the regulation of energy homeostasis
Poritsanos, N. J. (2010) · Mspace (University of Manitoba)
Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system
Hall, J. E., Omoto, A. C. M., do Carmo, J. M., da Silva, A. A., Mouton, A. J., Wang, Z., & Hall, M. E. (2026) · Clinical Science · doi:10.1042/cs20250039
BindingDB Entry 50038845: Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.
BindingDB (2012) · UC San Diego · doi:10.7270/q2d21zj5
Brain derived neurotrophic factor and structural vascular disease in black Africans : the SABPA study
Smith, A. J. (2014) · Boloka Institutional Repository (North-west University)
Environmental Manipulation and Neuropeptide Effects on Energy Balance and Cancer
Cao, L. (2015) · Energy balance and cancer · doi:10.1007/978-3-319-16733-6_2

Brain-Derived Neurotrophic Factor/Tropomyosin-Related Kinase Receptor Type B Signaling Is a Downstream Effector of the Brainstem Melanocortin System in Food Intake Control
Bariohay, B., Roux, J., Tardivel, C., Trouslard, J., Jean, A., & Lebrun, B. (2009) · Endocrinology · doi:10.1210/en.2008-1184 · Cited by 95 · see citing works
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience · doi:10.1038/nn1073 · Cited by 896 · see citing works
Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP – Protein kinase A pathway
Caruso, C. M., Carniglia, L., Durand, D., Gonzalez, P. V., Scimonelli, T. N., & Lasaga, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.036 · Cited by 72 · see citing works
Hypothalamic and Hindbrain Melanocortin Receptors Contribute to the Feeding, Thermogenic, and Cardiovascular Action of Melanocortins
Skibicka, K. P., & Grill, H. J. (2009) · Endocrinology · doi:10.1210/en.2009-0804 · Cited by 113 · see citing works
A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences
Benoit, S. C., Schwartz, M. W., Lachey, J. L., Hagan, M. M., Rushing, P. A., Blake, K. A., Yagaloff, K. A., Kurylko, G., Franco, L., Danhoo, W., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03442.2000 · Cited by 178 · see citing works

Authors: Nicholson, J. R., Peter, J. ‐., Lecourt, A. ‐., Barde, Y. ‐., & Hofbauer, K. G.
Affiliations: University of Basel (CH)
Corresponding author: Hofbauer, K. G.
ORCID: Lecourt, A.‐C.
Barde, Y.‐A.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2007-09-04
Volume: 19
Issue: 12
Pages: 974-982
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2007.01610.x
OpenAlex: W2094173172
Cited by: 87
References: 35
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 10 · 2013: 10 · 2012: 7
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: melanocortin-4 receptor, brain-derived neurotrophic factor, hypothalamus, food intake regulation, appetite, body temperature, cardiovascular function, mean arterial pressure, heart rate, cannabinoid 1 receptor, anorexia, intracerebroventricular administration
MeSH terms: Animals, Antibodies, Monoclonal, Appetite Depressants, Body Temperature, Cardiovascular System, Data Interpretation, Statistical, Eating, Hypothalamus, Injections, Intraventricular, Male, Melanocyte-Stimulating Hormones, Piperidines, Pyrazoles, Stereotaxic Techniques, Telemetry, Blotting, Western, Signal Transduction, Rats, Sprague-Dawley, Antibodies, Blocking, Brain-Derived Neurotrophic Factor, Receptor, Cannabinoid, CB1, Receptor, Melanocortin, Type 4, Rats, In Vitro Techniques

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Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function

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