The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Effects of orexin-A on memory processing
Abstract
Orexin-A is an endogenous peptide with receptors present throughout the brain. Here, we examined the effect of post-training administration of orexin-A on retention in active and passive avoidance. Orexin-A administered by intracerebroventricular (i.c.v.) injection to CD-1 mice post-training improved retention in both T-maze footshock avoidance and one trial step-down passive avoidance. SAMP8 mice have age-related deficits in learning and memory, which correlate with an increase in brain levels of beta amyloid (Abeta) and an impaired response to memory-enhancing compounds. Orexin-A at 3nmol improved retention in young and old SAMP8 mice. These findings show that orexin-A can improve memory even with overproduction of Abeta.
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“Orexin is also associated with memory processing,113–116 motivation, reward,117 and addiction,118 which have been described as behaviors that are affected by TBI.9,119–123”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [114]
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Metadata
- Authors
- Jaeger, L. B., Farr, S. A., Banks, W. A., & Morley, J. E.
- Affiliations
- St. Louis VA Medical Center (US)
- Corresponding author
- Farr, Susan A
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 23
- Issue
- 9
- Pages
- 1683-1688
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2068523799
- Cited by
- 116
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 8
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- orexin-A, memory consolidation, avoidance learning, passive avoidance, active avoidance, SAMP8 mice, age-related memory impairment, amyloid-beta, memory enhancement, intracerebroventricular administration
- MeSH terms
- Orexins, Animals, Avoidance Learning, Brain, Carrier Proteins, Dose-Response Relationship, Drug, Male, Memory, Neuropeptides, Time Factors, Amyloid beta-Peptides, Maze Learning, Intracellular Signaling Peptides and Proteins, Mice
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