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Effects of orexin-A on memory processing

Jaeger, Laura B, Farr, Susan A, Banks, William A, Morley, John E·2002·Peptides

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Abstract

Orexin-A is an endogenous peptide with receptors present throughout the brain. Here, we examined the effect of post-training administration of orexin-A on retention in active and passive avoidance. Orexin-A administered by intracerebroventricular (i.c.v.) injection to CD-1 mice post-training improved retention in both T-maze footshock avoidance and one trial step-down passive avoidance. SAMP8 mice have age-related deficits in learning and memory, which correlate with an increase in brain levels of beta amyloid (Abeta) and an impaired response to memory-enhancing compounds. Orexin-A at 3nmol improved retention in young and old SAMP8 mice. These findings show that orexin-A can improve memory even with overproduction of Abeta.

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Authors: Jaeger, L. B., Farr, S. A., Banks, W. A., & Morley, J. E.
Affiliations: St. Louis VA Medical Center (US)
Corresponding author: Farr, Susan A
ORCID: Farr, Susan A
Banks, William A
Morley, John E
Venue: Peptides
Publisher: Elsevier BV
Published: 2002-09
Volume: 23
Issue: 9
Pages: 1683-1688
ISSN: 0196-9781 (ISSN-L)
DOI: 10.1016/s0196-9781(02)00110-9
OpenAlex: W2068523799
Cited by: 116
References: 32
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 8
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Peptides (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: orexin-A, memory consolidation, avoidance learning, passive avoidance, active avoidance, SAMP8 mice, age-related memory impairment, amyloid-beta, memory enhancement, intracerebroventricular administration
MeSH terms: Orexins, Animals, Avoidance Learning, Brain, Carrier Proteins, Dose-Response Relationship, Drug, Male, Memory, Neuropeptides, Time Factors, Amyloid beta-Peptides, Maze Learning, Intracellular Signaling Peptides and Proteins, Mice

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