Cited by 410Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease

Braak, H, Braak, E·1997·Neurobiology of Aging

DOI 10.1016/s0197-4580(97)00062-6

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Abstract

Prior to any evaluation of morphologic brain changes, a decision must be made whether a given alteration is associated with aging or with disease. Patients with disease-related lesions may be in a clinically silent phase of a disease or show overt symptoms. Neurofibrillary tangles and neuropil threads are the hallmarks of Alzheimer's disease. They should not be considered to be age-related changes, even when they are present only in small numbers. In general, the initial changes consist of neurofibrillary tangles and neuropil threads. Plaques (amyloid deposits and/or neuritic plaques) are consistently present in the end stage of the disease. Initial neurofibrillary tangles and neuropil threads develop at specific cortical predilection sites. The changes then spread in a predictable, nonrandom manner across other portions of the telencephalic cortex. The sequential changes in the distribution pattern of the lesions provide the basis for a staging procedure that takes the slow and gradual progression of the destructive process into consideration. The staging procedure provides accurate diagnoses in the initial stages and even reveals brain changes developing prior to the appearance of clinical symptoms. It is thus advantageous in characterizing nondemented controls. The staging procedure can be carried out easily and does not require knowledge of clinical data, quantitative assessments, or adjustments for the age of the patients. Application of advanced silver techniques (Gallyas, Campbell-Switzer) to demonstrate Alzheimer's disease-related lesions also allows recognition of the hallmarks of other disorders, such as Lewy body disease (Parkinson's disease) and dementia with argyrophilic grains, which frequently co-occur with Alzheimer's disease.

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Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Self-citation
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769
Self-citation
Alzheimer's Disease: A Central Role for Amyloid
Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752
Tau protein and the neurofibrillary pathology of Alzheimer's disease
Goedert, M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90078-z · Cited by 721
The Prevalence of Dementia in Europe: A Collaborative Study of 1980–1990 Findings
Albert Hofman, D., Rocca, W. A., Brayne, C., Breteler, M. M. B., Clarke, M., Cooper, B. K., Copeland, J. R. M., Dartigues, J. F., Droux, A. D. S., Hagnell, O., et al. (1991) · International Journal of Epidemiology · doi:10.1093/ije/20.3.736 · Cited by 667

Show all 39 references

Research works printed but not linked: 1

Duyckaerts, 1994, Diagnosis and staging of Alzheimer’s disease in a prospective study involving aged individuals, Neurobiol. Aging, 15, 140

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Dowling, N. M., Farias, S. T., Reed, B., Sonnen, J. A., Strauss, M. E., Schneider, J. A., Bennett, D. A., & Mungas, D. (2010) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617710001426 · Cited by 47
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Harrison, J. R., Bhatia, S., Tan, Z. X., Mirza-Davies, A., Benkert, H., Tax, C. M. W., & Jones, D. K. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102359 · Cited by 50
“According to this hypothesis, patterns of white matter alterations should correspond to grey matter pathology, occurring first in the hippocampal and entorhinal areas, before extending to wider temporal and parietal regions (Braak & Braak, 1997).”
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Louis, E. D., Kuo, S., Vonsattel, J., & Faust, P. L. (2014) · The Cerebellum · doi:10.1007/s12311-014-0556-5 · Cited by 46
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Kuo, S., Wang, J., Tate, W. J., Pan, M., Kelly, G. C., Gutierrez, J., Cortes, E. P., Vonsattel, J., Louis, E. D., & Faust, P. L. (2016) · The Cerebellum · doi:10.1007/s12311-016-0826-5 · Cited by 45
“brain in a cold room or upon ice), Braak and Braak AD staging for neurofibrillary tangles [23, 24], and Consortium to Establish a Registry for AD (CERAD) ratings for neuritic plaques [25].”
Background
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Schubert, C. R., Cruickshanks, K. J., Fischer, M., Pinto, A. A., Chen, Y., Huang, G.-H., Klein, R., Klein, R., Pankow, J. S., Paulsen, A. J., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz011 · Cited by 42
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Background
Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases
Otto, M., Lewczuk, P., & Wiltfang, J. (2008) · Methods · doi:10.1016/j.ymeth.2007.06.012 · Cited by 44
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Rüb, U., Tredici, K. D., Schultz, C., Büttner-Ennever, J. A., & Braak, H. (2001) · Vision Research · doi:10.1016/s0042-6989(01)00090-6 · Cited by 44
Self-citation
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Louis, E. D., Factor-Litvak, P. R., Liu, X., Vonsattel, J., Galecki, M., Jiang, W., & Zheng, W. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.07.002 · Cited by 43
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Yin, R.-H., Tan, L., Liu, Y., Wang, W.-Y., Wang, H.-F., Jiang, T., Raduà, J., Zhang, Y., Gao, J., Canu, E., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150139 · Cited by 42
Extracellular Amyloid-β and Cytotoxic Glial Activation Induce Significant Entorhinal Neuron Loss in Young PS1M146L/APP751SL Mice
Moreno‐González, I., Baglietto‐Vargas, D., Sanchez-Varo, R. M., Jiménez, S., Trujillo‐Estrada, L., Sánchez‐Mejías, E., del Río, J. C., Torres, M., Romero‐Acebal, M., Ruano, D., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1192 · Cited by 42
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation
Cuadrado‐Tejedor, M., Ricobaraza, A., Río, J. D., Frechilla, D., Franco, R., Pérez‐Mediavilla, A., & García‐Osta, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.005 · Cited by 42
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Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A. L., Nik, S. H. M., Dong, Y., Zhou, X., Manucat-Tan, N. B., Ludington, A. J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227258 · Cited by 40
“Many people also have brains containing high levels of Aβ [83] or Braak stage III to VI neurodegeneration [79] without obvious dementia.”
BackgroundInfluential
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“We primarily focused our nalysis on the medial temporal lobe since its structures re among the earliest to show AD-related pathology Braak and Braak, 1997).”
Background
Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease
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Russo, C., Dolcini, V., Salis, S., Venezia, V., Violani, E., Carlo, P., Zambrano, N., Russo, T., & Schettini, G. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04660.x · Cited by 39
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Wilkins, H. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220518 · Cited by 37
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Miller, V. M., Kenny, R. A., Slade, J. Y., Oakley, A. E., & Kalaria, R. N. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00903.x · Cited by 43
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Authors: Braak, H., & Braak, E.
Affiliations: Goethe University Frankfurt (DE)
Corresponding author: Braak, H
ORCID: Braak, H
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1997-07
Volume: 18
Issue: 4
Pages: S85-S88
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(97)00062-6
OpenAlex: W2015001118
Cited by: 410
References: 39
Citations by year: 2026: 9 · 2025: 9 · 2024: 9 · 2023: 21 · 2022: 7 · 2021: 16 · 2020: 20 · 2019: 13 · 2018: 20 · 2017: 12 · 2016: 16 · 2015: 21 · 2014: 16 · 2013: 22 · 2012: 25
FWCI: 1.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, neuropathologic diagnosis, neurofibrillary tangles, neuropil threads, amyloid plaques, silver staining, Lewy body disease, brain aging
MeSH terms: Aged, Aging, Alzheimer Disease, Brain, Humans, Severity of Illness Index, Neurofibrillary Tangles, Disease Progression, Neuropil Threads, Plaque, Amyloid

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Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease

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