Synaptophysin and Synaptojanin-1 in Down Syndrome are Differentially Affected by Alzheimer's Disease

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Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

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Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

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Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.

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Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

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A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

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Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction

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Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

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Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome

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Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

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<i>App</i>Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome

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Neurological phenotypes for Down syndrome across the life span

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Abnormalities of the nucleus basalis in Down's syndrome

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Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

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Genetic and host factors for dementia in Down's syndrome

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Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

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p145, a major Grb2-binding protein in brain, is co-localized with dynamin in nerve terminals where it undergoes activity-dependent dephosphorylation.

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Precocious aging and dementia in patients with Down's syndrome.

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Synaptic proteins, neuropathology and cognitive status in the oldest-old

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Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid

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Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in down syndrome: Quantitative comparison with alzheimer dementia

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Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer’s disease

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Mortality of people with mental retardation in California with and without Down syndrome, 1986-1991.

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Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

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Possible Compensatory Events in Adult Down Syndrome Brain Prior to the Development of Alzheimer Disease Neuropathology: Targets for Nonpharmacological Intervention

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Excessive expression of synaptojanin in brains with Down syndrome

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Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part I)

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Total numbers of neurons and glial cells in cortex and basal ganglia of aged brains with Down syndrome-a stereological study.

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Reduction of Synaptojanin 1 Ameliorates Synaptic and Behavioral Impairments in a Mouse Model of Alzheimer's Disease

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Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: Implications for Down syndrome

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Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse.

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MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins

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Alzheimer patients and Down patients: Abnormal presynaptic terminals are related to cerebral preamyloid deposits

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Some morphometric observations on the brains of patients with Down's syndrome: their relationship to age and dementia

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Loss of synaptophysin and synaptosomal‐associated protein 25‐kDa (SNAP‐25) in elderly Down syndrome individuals

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Entorhinal cortex of aged subjects with Down's syndrome shows severe neuronal loss caused by neurofibrillary pathology

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Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part III)

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Predicting pathway perturbations in Down syndrome

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Topography of nerve cell loss from the locus caeruleus in middle aged persons with Down's syndrome

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Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome

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Assignment 1 of SYNJ1 to human chromosome 21q22.2 and Synj12 to the murine homologous region on chromosome 16C3–4 by in situ hybridization

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Effects of nonsteroidal anti-inflammatory drugs on amyloid-β pathology in mouse skeletal muscle

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Dementia in Down syndrome: unique insights for Alzheimer disease research

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Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

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Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer’s Disease

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Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

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Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

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Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

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Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease?

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Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

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Synaptojanin 1 Mutation in Parkinson’s Disease Brings Further Insight into the Neuropathological Mechanisms

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PIPs in neurological diseases

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Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease

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Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

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Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

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Down syndrome, beta-amyloid and neuroimaging

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Altered protein phosphorylation as a resource for potential AD biomarkers

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PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts

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Dissecting Alzheimer disease in Down syndrome using mouse models

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Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome

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CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation

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Prion Protein Interactome: Identifying Novel Targets in Slowly and Rapidly Progressive Forms of Alzheimer’s Disease

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The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome

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Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans

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The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer’s disease

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Acupuncture accelerates neural regeneration and synaptophysin production after neural stem cells transplantation in mice

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Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod

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The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity

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Focusing on cellular biomarkers: The endo-lysosomal pathway in Down syndrome.

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Edaravone Dexborneol ameliorates the cognitive deficits of APP/PS1 mice by inhibiting TLR4/MAPK signaling pathway via upregulating TREM2

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Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose

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A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

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Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway

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The effects of early life lead exposure on the expression of P2X7 receptor and synaptophysin in the hippocampus of mouse pups

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Triplication of Synaptojanin 1 in Alzheimer’s Disease Pathology in Down Syndrome

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