The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease
Open accessAbstract
The senile plaque is the pathological hallmark of Alzheimer's disease. Senile plaques are composed of beta amyloid fibrils, associated with activated microglia, astrocytes, and dystrophic neurons. We have recently identified class A scavenger receptors as the main receptors mediating the interaction of microglia with beta amyloid fibrils. Adhesion of microglia to beta amyloid fibrils leads to immobilization of these cells on the fibrils, and induces them to produce reactive oxygen species. We propose that interactions of microglial scavenger receptors with fibrillar beta amyloid may stimulate the microglia to secrete apolipoprotein E and complement proteins, which may further contribute to neurotoxicity and neuronal degeneration. Therefore, microglial scavenger receptors may be novel targets for therapeutic interventions in Alzheimer's disease.
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Cites
Activation of microglial cells by β-amyloid protein and interferon-γ
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Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
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Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896
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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
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Self-citationβ-Amyloid-mediated vasoactivity and vascular endothelial damage
Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703
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Role of the β‐amyloid protein in Alzheimer's disease
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Cited by
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
“…receptors that promote the clearance and phagocytosis of A , such as class A scavenger receptor, CD36, and receptor for advanced-glycosylation endproducts (RAGE) (Yan et al., 1996; El Khoury et al., 1998), and microglia can restrict senile plaque formation by phagocytosing A (Simard et al., 2006).”
Self-citationInflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975
El Khoury, J., Toft, M., Hickman, S. E., Means, T. K., Terada, K., Geula, C., & Luster, A. D. (2007) · Nature Medicine · doi:10.1038/nm1555 · Cited by 915
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Metadata
- Authors
- El Khoury, J., Hickman, S. E., Thomas, C. A., Loike, J. D., & Silverstein, S. C.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 19
- Issue
- 1
- Pages
- S81-S84
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1983731041
- Cited by
- 159
- References
- 8
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- El Khoury, J., Hickman, S. E., Thomas, C. A., Loike, J. D., & Silverstein, S. C. (1998). Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease. Neurobiology of Aging. https://doi.org/10.1016/s0197-4580(98)00036-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
