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The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

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The potential therapeutic effects of ergothioneine in pre-eclampsia

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Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

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Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

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Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging

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Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?

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Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzheimer's disease

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Ergothioneine in the brain

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Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics

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A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

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Emerging drug targets for A β and tau in Alzheimer's disease: a systematic review

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Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice

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Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

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Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal‐Induced Injuries in Rat Pheochromocytoma Cells

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Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism

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Ergothioneine: new functional factor in fermented foods

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Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer’s type (SDAT) caused by intracerebroventricular streptozotocin in rats

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Ergothioneine ameliorates oxaliplatin-induced peripheral neuropathy in rats

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Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging

Roda, E., Ratto, D., Luca, F. D., Desiderio, A., Ramieri, M., Goppa, L., Savino, E., Bottone, M. G., Locatelli, C., & Rossi, P. (2022) · Nutrients · doi:10.3390/nu14061177 · Cited by 46 · see citing works

Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?

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Efficient Synthesis of Food-Derived Antioxidant l -Ergothioneine by Engineered Corynebacterium glutamicum

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Investigating the efficacy of ergothioneine to delay cognitive decline in mild cognitively impaired subjects: A pilot study

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The Bioactive Compounds in Medicinal Mushrooms have Potential Protective Effects against Neurodegenerative Diseases

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Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract

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Matching chemical properties to molecular biological activities opens a new perspective on l ‐ergothioneine

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Phytochemical composition, antioxidant activity and neuroprotective effect of Crataegus pinnatifida fruit

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Ergothioneine and central nervous system diseases

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Metabolomic and lipidomic signatures in autosomal dominant and late‐onset Alzheimer's disease brains

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l -Ergothioneine Exhibits Protective Effects against Dextran Sulfate Sodium-Induced Colitis in Mice

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Food-derived antioxidant ergothioneine improves sleep difficulties in humans

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High throughput multiorgan metabolomics in the APP/PS1 mouse model of Alzheimer's disease

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Cultivated mushrooms: importance of a multipurpose crop, with special focus on Italian fungiculture

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Ergothioneine exerts neuroprotective effects in Parkinson’s disease: Targeting α-synuclein aggregation and oxidative stress

Gao, W., Wang, Y., Wang, F., Wu, X., Lu, F., & Liu, F. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115590 · Cited by 28 · see citing works

Engineering non-conventional yeast Rhodotorula toruloides for ergothioneine production

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Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells

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Quantification of ergothioneine in Aspergillus oryzae-fermented rice bran by a newly-developed LC/ESI-MS/MS method

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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a d -galactose-induced aging model

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Biosynthesis of ergothioneine: current state, achievements, and perspectives

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Ergothioneine Prevents Neuronal Cell Death Caused by the Neurotoxin 6-Hydroxydopamine

Yuzawa, S., Nakashio, M., Ichimura, S., Shimoda, M., Nakashima, A., Marukawa-Hashimoto, Y., Kawano, Y., Suzuki, K., Yoshitomi, K., Kawahara, M., et al. (2024) · Cells · doi:10.3390/cells13030230 · Cited by 23 · see citing works

Bioactive constituents from Medicago sativa L. with antioxidant, neuroprotective and acetylcholinesterase inhibitory activities

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The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9 mouse model of cystinuria

Mayayo‐Vallverdú, C., de Heredia, M. L., Prat, E., González, L., Guarch, M. E., Vilches, C., Muñoz, L., Asensi, M. A., Serra, C., Llebaria, A., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102801 · Cited by 20 · see citing works

Protective Effect of Ergothioneine against Oxidative Stress-Induced Chondrocyte Death

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Integration of transcriptomics and metabolomics confirmed hepatoprotective effects of steamed shoot extracts of ginseng (Panax ginseng C.A. Meyer) on toxicity caused by overdosed acetaminophen

Yao, F., Wang, X., Cao, X., Zhang, K., Sun, J. Y., Li, Y., Sui, J., & Liu, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112177 · Cited by 20 · see citing works

Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons

Leow, D. M.-K., Cheah, I. K.-M., Chen, L., Ng, Y. K., Yeo, C. J.-J., Halliwell, B. B., & Ong, W. (2024) · Antioxidants · doi:10.3390/antiox13060693 · Cited by 19 · see citing works

Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models

Tng, T. J. W., Leow, D. M.-K., Goh, G., Wang, Z., Liu, Y., Tang, R. M. Y., Lai, K. C., Basil, A. H., Choong, H. C., Goh, W. W. B., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70168 · Cited by 16 · see citing works

Protective Effect of Ergothioneine Against Stroke in Rodent Models

Ong, W., Kao, M.-H., Cheung, W., Leow, D. M.-K., Cheah, I. K.-M., & Lin, T. (2022) · NeuroMolecular Medicine · doi:10.1007/s12017-022-08727-w · Cited by 18 · see citing works

Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice

Nishiyama, M., Nakamichi, N., Yoshimura, T., Masuo, Y., Komori, T., Ishimoto, T., Matsuo, J., & Kato, Y. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03118-8 · Cited by 17 · see citing works

Ergothioneine as a promising natural antioxidant: bioactivities, therapeutic potential, and industrial applications

Lei, Z., Wang, Z., Zhang, H., Jia, Y., Zhang, D., Shi, R., Wang, C., & Chen, W. (2025) · Food & Function · doi:10.1039/d5fo02337h · Cited by 18 · see citing works

TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans

Ishimoto, T., Yamashita, R., Matsumoto, R., Matsumoto, S., Matsuo, Y., Nakao, S., Masuo, Y., Suzuki, M., & Kato, Y. (2024) · npj Science of Food · doi:10.1038/s41538-024-00250-5 · Cited by 16 · see citing works

Biosynthetic ability of diverse basidiomycetous yeast strains to produce the natural antioxidant ergothioneine

Sato, S., Saika, A., Ushimaru, K., Koshiyama, T., Higashiyama, Y., Fukuoka, T., & Morita, T. (2024) · AMB Express · doi:10.1186/s13568-024-01672-w · Cited by 16 · see citing works

Synergistic Neuroprotective Effects of Ergothioneine and Lactoferrin in APP/PS1 Transgenic Mice and Mouse N2a Cells

Li, H., Wang, X., Li, R., Chen, L., Cheng, G., & Xiong, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c10263 · Cited by 14 · see citing works

Innovative mycelium‐based food: Advancing One Health through nutritional insights and environmental sustainability

Wang, X., Pei, Y., Wu, J., Zhong, X., Liu, H., & Xue, Y. (2025) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70166 · Cited by 14 · see citing works

L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms

Saraswathy, N., Kandasamy, R., Ponnusamy, R., DeRuiter, J., Dhanasekaran, M., & Thilagar, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-6382-5_16 · Cited by 13 · see citing works

Advances on the biosynthesis of ergothioneine using microbial chassis

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Gut Microbiota-Driven Metabolic Alterations Reveal the Gut-Brain Communication of Ergothioneine in Ameliorating Cognitive Impairment in APP/PS1 Mice

Li, N., Wang, S., Li, H., Liu, Z., Mo, H., Luan, J., Guo, N., Gou, X., Wu, Y., & Li, Z. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c02557 · Cited by 12 · see citing works

Intranasal administration of ergothioneine improves memory in a mouse model of multiple system atrophy

Kimura, K., Tanaka, M. T., Miki, Y., Furukawa, T., Kasai, S., Ozaki, T., Mori, F., Shibuya, E., & Wakabayashi, K. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151550 · Cited by 10 · see citing works

A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications

Behof, W. J., Whitmore, C. A., Haynes, J. R., Rosenberg, A. J., Tantawy, M. N., Peterson, T. E., Harrison, F. E., Beelman, R. B., & Pham, W. N. (2021) · Scientific Reports · doi:10.1038/s41598-021-97925-w · Cited by 10 · see citing works

Engineering Saccharomyces boulardii for Probiotic Supplementation of l ‐Ergothioneine

Tang, C., Zhang, L., Wang, J., Zou, C., Zhang, Y., & Yuan, J. (2024) · Biotechnology Journal · doi:10.1002/biot.202400527 · Cited by 9 · see citing works

Construction of a genetic linkage map and detection of quantitative trait locus for the ergothioneine content in tamogitake mushroom (Pleurotus cornucopiae var. citrinopileatus)

Yoneyama, S., Maeda, K., Sadamori, A., Saitoh, S., Tsuda, M., Azuma, T., Nagano, A. J., Tomiyama, T., & Matsumoto, T. (2021) · Mycoscience · doi:10.47371/mycosci.2020.11.003 · Cited by 8 · see citing works

Ergothioneine attenuates varicocele‐induced testicular damage by upregulating HSP90AA1 in rats

Chen, Q., Zhou, R., Yang, C., Jiang, Q., Yuan, H., Qiu, X. Y., Tian, H., Zhou, J., & Liu, C. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23301 · Cited by 9 · see citing works

L -Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in C57BL/6J mice by activating DJ-1

Meng, X., Meng, H., Hou, S., Yin, Z., Wang, X., Gong, K., Zhang, F., Li, Q., Zhang, S., Chen, Y., et al. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250068 · Cited by 7 · see citing works

Ergothioneine: A Multifunctional Dietary Antioxidant with Emerging Therapeutic Potential

Chen, K., Chen, X., He, W., Deng, W., Wu, M., Li, H., Shen, Y., & Zhang, L. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2513568 · Cited by 7 · see citing works

Serum ergothioneine and risk of dementia in a general older Japanese population: the Hisayama Study

Meng, X., Ohara, T., Nishioka, K., Shibata, M., Katsube, M., Tateishi, N., Nakamura, Y., Oishi, E., Sakata, S., Furuta, Y., et al. (2025) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13893 · Cited by 7 · see citing works

The Current Situation and Future Trends of Ergothioneine in Biology and Medical Research: A Bibliometric Analysis

Fu, Y., Guan, H., Yu, M., Jiang, P., He, X., Bao, J., Zhang, B., & Yan, L. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s547548 · Cited by 7 · see citing works

Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

Xu, X., Jia, L., Ma, X., Li, H., & Sun, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.792331 · Cited by 7 · see citing works

Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs)

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Advances and prospects of ergothioneine in the treatment of cognitive frailty

Gede, A. M. M. I., Gu, Q., Phukhatmuen, P., Xiong, J., Zhang, S., Yi, M., Vadphimai, S., & Qi, W. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2555742 · Cited by 6 · see citing works

Do Ganoderma lucidum and Salvia officinalis extracts exhibit synergistic antioxidant and antineurodegenerative effects?

Ćilerdžić, J. L., Aradski, A. A., Stajić, M. M., Vukojević, J. B., & Duletić-Laušević, S. N. (2019) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-019-00258-6 · Cited by 7 · see citing works

Ergothioneine Stimulates Ca2+-Mediated Brain-Derived Neurotrophic Factor Expression in NE-4C Nerve Cells

Shi, C., Asaba, S., Nakamura, S., & Matsui, T. (2025) · ACS Omega · doi:10.1021/acsomega.4c09920 · Cited by 5 · see citing works

Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments

Zheng, M., Yan, H., Hao, W., An, H., Chen, X., Wu, Q., Ge, X., Ye, H., Zhou, M., Zhou, G., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.03.020 · Cited by 5 · see citing works

The Role of Antioxidant on Health and Age-Related Diseases in Aging

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L-ergothioneine; a potential adjuvant in the management of diabetic nephropathy

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Mushroom intake and risk of incident disabling dementia: the Circulatory Risk in Communities Study (CIRCS)

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The Potentials of Ergothioneine in the management of diseases in animals

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Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer disease brainsPreprint

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Revalorization of brewer’s spent grain through solid-state fermentation with Pleurotus ostreatus

Pascual, M. M., Painefilú, J. C., Ranalli, N., Santos, M. V., Langenheim, M., Campos, M., Jurski, V., & Luquet, C. M. (2025) · Food and Humanity · doi:10.1016/j.foohum.2025.100984 · Cited by 3 · see citing works

Ergothioneine as a potential geroprotector: Targeting molecular hallmarks of ageing and age-related diseases

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Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Cheah, I. K.-M., Ng, L. T., Ng, L. F., Lam, V. Y. M., Gruber, J., Huang, C. Y. W., Goh, F., Lim, K. H. C., & Halliwell, B. B. (2019) · FEBS Letters · doi:10.1002/1873-3468.13497 · Cited by 49 · see citing works

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease

Whitmore, C. A., Haynes, J. R., Behof, W. J., Rosenberg, A. J., Tantawy, M. N., Hachey, B. C., Wadzinski, B. E., Spiller, B. W., Peterson, T. E., Paffenroth, K. C., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060742 · Cited by 50 · see citing works

Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose

Song, T., Lin, H., Chen, C.-L., Wu, J., Liao, J., & Hu, M. (2014) · Free Radical Research · doi:10.3109/10715762.2014.920954 · Cited by 84 · see citing works

Anti-amnesic effect of ESP-102 on Aβ1–42-induced memory impairment in mice

Kim, D., Jung, W. Y., Park, S. J., Kim, J. M., Lee, S., Kim, Y. C., & Ryu, J. H. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.08.005 · Cited by 18 · see citing works

Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease

Wijesinghe, P., Whitmore, C. A., Campbell, M., Li, C. H., Tsuyuki, M., To, E. C., Haynes, J. R., Pham, W. N., & Matsubara, J. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1107436 · Cited by 36 · see citing works