The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Strategy for construction of live picornavirus vaccines
Abstract
A number of recombinant viruses between the virulent Mahoney and the attenuated Sabin 1 strains of type 1 poliovirus were constructed in vitro using their infectious cDNA clones. Monkey neurovirulence tests on these recombinant viruses revealed that the surface structure of the virion particle had a little correlation with the neurovirulent phenotype, and that the strong neurovirulence determinant(s) resided in the 5' noncoding sequence. These results in turn led to two possible strategies for constructing live attenuated picornavirus strains. One is to use the Sabin 1 strain as a vector carrying foreign antigenicities. The other is the construction of the attenuated picornaviruses by introducing mutations into the 5' noncoding sequences. The antigenicity of the Sabin 1 strain was successfully changed to those of other poliovirus serotypes without loss of vaccine quality. Furthermore, it was proved that introduction of deletion mutation into the 5' noncoding sequence of genomes of the Sabin 1 and Mahoney strains resulted in construction of viruses with a less neurovirulent phenotype.
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“Similar highly favorable results were achieved in other developed countries (139, 178, 201).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [139]
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Cites
Rapid Evolution of RNA Genomes
Holland, J. J., Spindler, K. R., Horodyski, F. M., Grabau, E. A., Nichol, S. T., & VandePol, S. (1982) · Science · doi:10.1126/science.7041255 · Cited by 1,478
Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution
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Primary structure, gene organization and polypeptide expression of poliovirus RNA
Kitamura, N., Semler, B. L., Rothberg, P. G., Larsen, G. R., Adler, C. J., Dorner, A. J., Emini, E. A., Hanecak, R., Lee, J. J., van der Werf, S., et al. (1981) · Nature · doi:10.1038/291547a0 · Cited by 914
Cloned Poliovirus Complementary DNA Is Infectious in Mammalian Cells
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Complete nucleotide sequences of all three poliovirus serotype genomes
Toyoda, H., Kohara, M., Kataoka, Y., Suganuma, T., Omata, T., Imura, N., & Nomoto, A. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90084-6 · Cited by 415
Self-citationComplete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.
Nomoto, A., Omata, T., Toyoda, H., Kuge, S., Horie, H., Kataoka, Y., Genba, Y., Nakano, Y., & Imura, N. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.19.5793 · Cited by 308
Self-citationSabin, A. B. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/151.3.420 · Cited by 281
Paul, J. R. (1971) · Cited by 198
Genetic analysis of the attenuation phenotype of poliovirus type 1
Omata, T., Kohara, M., Kuge, S., Komatsu, T., Abe, S., Semler, B. L., Kameda, A., Itoh, H., Arita, M., & Wimmer, E. (1986) · Journal of Virology · doi:10.1128/jvi.58.2.348-358.1986 · Cited by 190
Self-citation(1986) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240320805 · Cited by 179
Research works printed but not linked: 1
- Nomoto, 1987, Vol. 1, 43
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VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703
Kawamura, N., Kohara, M., Abe, S., Komatsu, T., Tago, K., Arita, M., & Nomoto, A. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1302-1309.1989 · Cited by 232
Self-citationSutter, R. W., Kew, O. M., & Cochi, S. L. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-3611-1.50030-1 · Cited by 167
Bloom, B. R. (1989) · Nature · doi:10.1038/342115a0 · Cited by 136
Iizuka, N., Kohara, M., Hagino-Yamagishi, K., Abe, S., Komatsu, T., Tago, K., Arita, M., & Nomoto, A. (1989) · Journal of Virology · doi:10.1128/jvi.63.12.5354-5363.1989 · Cited by 107
Self-citation
Metadata
- Authors
- Nomoto, A., Iizuka, N., Kohara, M., & Arita, M.
- Affiliations
- Tokyo Metropolitan Institute of Medical Science (JP)
- ORCID
- Kohara, Michinori
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 1988-04
- Volume
- 6
- Issue
- 2
- Pages
- 134-137
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2023403791
- Cited by
- 24
- References
- 20
- Citations by year
- 2013: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Health Sciences Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- live attenuated vaccine, picornavirus, poliovirus, Mahoney strain, neurovirulence, antigenic variation, recombinant virus, infectious clone, antigenic determinants
- MeSH terms
- Chromosome Deletion, DNA, Mutation, Picornaviridae, Poliovirus Vaccine, Oral, Recombination, Genetic, Vaccines, Attenuated, Viral Vaccines, Virulence, Poliovirus
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