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Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood

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Increased cytokine production in mononuclear cells of healthy elderly people

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The immunology of exceptional individuals: the lesson of centenarians

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Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

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Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians [see comments]

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The Aging Thyroid

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Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians

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Aging and Cancer: The Double‐Edged Sword of Replicative Senescence

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CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory

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Thyroid and other organ-specific autoantibodies in healthy ceritenarians

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Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levels

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Involvement of growth factors in thymic involution

García‐Suárez, O., Pérez‐Pérez, M., Germanà, A., Esteban, I., & Germanà, G. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10413 · Cited by 33

Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background

Vibert, J., & Thomas‐Vaslin, V. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005417 · Cited by 31

Increased quinolinic acid in peripheral mononuclear cells in Alzheimer’s dementia

Busse, M., Hettler, V., Fischer, V., Mawrin, C., Hartig, R., Dobrowolny, H., Bogerts, B., Frodl, T., & Busse, S. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0785-y · Cited by 31

Stem cells and aging from a quasi‐immortal point of view

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Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus

Lustig, A., Weeraratna, A. T., Wood, W. W., Teichberg, D., Bertak, D., Carter, A., Poosala, S., Firman, J., Becker, K. G., Zonderman, A. B., et al. (2007) · Cellular Immunology · doi:10.1016/j.cellimm.2007.03.008 · Cited by 30

Growing old with the immune system: a study of immunosenescence in the zebra finch (Taeniopygia guttata)

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Sepsis-induced Cardiac Mitochondrial Damage and Potential Therapeutic Interventions in the Elderly

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Targeting inhibitory pathways in cancer immunotherapy

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DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans

McHugh, D. R., Koumis, E., Jacob, P., Goldfarb, J. A., Schlaubitz-Garcia, M., Bennani, S., Regan, P., Patel, P., & Youngman, M. J. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401166 · Cited by 28

Investigation of KIR diversity in immunosenecence and longevity within the Irish population

Maxwell, L. D., Ross, O. A., Curran, M. D., Rea, I. M., & Middleton, D. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.05.003 · Cited by 27

The effect of aging on immune responses

Fermaglich, D. H., & Horohov, D. W. (2002) · Veterinary Clinics of North America Equine Practice · doi:10.1016/s0749-0739(02)00027-5 · Cited by 27

Balanced Regulation of mRNA Production for Fas and Fas Ligand in Lymphocytes From Centenarians

Pinti, M., Troiano, L., Nasi, M., Bellodi, C., Ferraresi, R., Mussi, C., Salvioli, G., & Cossarizza, A. (2004) · Circulation · doi:10.1161/01.cir.0000146903.43026.82 · Cited by 27

A cytofluorimetric study of T lymphocyte subsets in rat lymphoid tissues (thymus, lymph nodes) and peripheral blood: a continuous remodelling during the first year of life

Capri, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00107-8 · Cited by 27

A Stochastic Model for CD8+T Cell Dynamics in Human Immunosenescence: Implications for Survival and Longevity

Luciani, F., Valensin, S., Vescovini, R., Sansoni, P., Fagnoni, F. F., Franceschi, C., Bonafè, M., & Turchetti, G. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2433 · Cited by 26

Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy

Buigues, C., Navarro-Martínez, R., Sánchez‐Martínez, V., Serrano-Carrascosa, M., Rubio‐Briones, J., & Cauli, O. (2020) · Cancers · doi:10.3390/cancers12071716 · Cited by 25

Age is associated with asthma phenotypes

Ponte, E. V., Lima, A. M. P., Almeida, P. C. A., de Jesus, J. P. V., Lima, V. B., Scichilone, N., Souza‐Machado, A., & Cruz, Á. A. (2017) · Respirology · doi:10.1111/resp.13102 · Cited by 25

Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age

Moore, B. A., Albers, K. M., Davis, B. M., Grandis, J. R., Tögel, S., & Bauer, A. J. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00570.2006 · Cited by 25

Immune monitoring as prerequisite for transplantation tolerance trials

Sani, K. B., & Sawitzki, B. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.12988 · Cited by 24

Age Is Not Associated with Hospital Admission or Uncontrolled Symptoms of Asthma if Proper Treatment Is Offered

Ponte, E. V., Stelmach, R., Franco, R. A., Souza‐Machado, C., Souza‐Machado, A., & Cruz, Á. A. (2014) · International Archives of Allergy and Immunology · doi:10.1159/000367924 · Cited by 24

Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans

Mocchegiani, E., Giacconi, R., Muti, E., Cipriano, C., Costarelli, L., Tesei, S., Gasparini, N., & Malavolta, M. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-7 · Cited by 24

Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype

Salvioli, S., Capri, M., Scarcella, E., Mangherini, S., Faranca, I., Volterra, V., Ronchi, D. D., Marini, M., Bonafè, M., Franceschi, C., et al. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00016-2 · Cited by 24

On Patient’s Characteristics Extraction for Metabolic Syndrome Diagnosis: Predictive Modelling Based on Machine Learning

Babič, F., Majnarić, L. T., Lukáčová, A., Paralič, J., & Holzinger, A. (2014) · Lecture notes in computer science · doi:10.1007/978-3-319-10265-8_11 · Cited by 23

The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: A case–control study

Islam, J., Taylor, A. L., Rao, K. K., Huffnagle, G. B., Young, V. B., Rajkumar, C., Cohen, J., Papatheodorou, P., Aronoff, D. M., & Llewelyn, M. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.03.011 · Cited by 23

Non-genetic Heterogeneity of Macrophages in Diseases—A Medical Perspective

Gessain, G., Blériot, C., & Ginhoux, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613116 · Cited by 24

Dehydroepiandrosterone Sulphate Enhances IgG and Interferon-Gamma Production During Immunization to Tuberculosis in Young But not Aged Mice

Ribeiro, F., Lopes, R. P., Nunes, C. P., Maito, F. L. D. M., Bonorino, C., & Bauer, M. E. (2006) · Biogerontology · doi:10.1007/s10522-006-9069-z · Cited by 23

Old mice accumulate activated effector CD4 T cells refractory to regulatory T cell-induced immunosuppression

Harpaz, I., Bhattacharya, U., Elyahu, Y., Strominger, I., & Monsonego, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00283 · Cited by 22

Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection

Easterbrook, J. D., Kash, J. C., Sheng, Z., Qi, L., Gao, J., Kilbourne, E. D., Eichelberger, M. C., & Taubenberger, J. K. (2011) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2010.00191.x · Cited by 23

Evidence for Less Marked Potential Signs of T-Cell Immunosenescence in Centenarian Offspring Than in the General Age-Matched Population

Pellicanò, M., Buffa, S., Goldeck, D., Bulati, M., Martorana, A., Caruso, C., Colonna‐Romano, G., & Pawelec, G. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt120 · Cited by 22

Molecular Basis of Accelerated Aging with Immune Dysfunction-Mediated Inflammation (Inflamm-Aging) in Patients with Systemic Sclerosis

Shen, C., Lu, C., Wu, C.-H., Li, K., Kuo, Y., Hsieh, S., & Yu, C. (2021) · Cells · doi:10.3390/cells10123402 · Cited by 22

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice

Namas, R. A., Bartels, J. D., Hoffman, R. A., Barclay, D. A., Billiar, T. R., Zamora, R., & Yoram Vodovotz, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067419 · Cited by 22

Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism

Tana, C., Lauretani, F., Ticinesi, A., Prati, B., Nouvenne, A., & Meschi, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051299 · Cited by 22

Best practice recommendations for the selection and management of patients with multiple sclerosis receiving natalizumab therapy

Coyle, P. K., Foley, J. F., Fox, E., Jeffery, D., Munschauer, F. E., & Tornatore, C. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509347131 · Cited by 22

Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis

Comin, F., Speziali, E., Martins‐Filho, O. A., Caldas, I. R., Moura, V., Gazzinelli, A., Corrêa‐Oliveira, R., & Faria, A. M. C. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03403.x · Cited by 22

CD8 T-cell immune phenotype of successful aging

Hsu, H. C., Scott, D. K., Zhang, P., Zhou, J., Yang, P. A., Wu, Q., Schroeder, H. W., Gerald, L. B., Ravussin, É., & Jazwinski, S. M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.10.001 · Cited by 22

Whole Blood Analysis of Phagocytosis, Apoptosis, Cytokine Production, and Leukocyte Subsets in Healthy Older Men and Women: The ZENITH Study

Hodkinson, C., O’Connor, J. M., Alexander, H. D., Bradbury, I., Bonham, M. P., HANNIGAN, B. M., Gilmore, W. S., Strain, J. J., & Wallace, J. M. W. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.907 · Cited by 22

Age-related ocular surface failure: A narrative review

Zazzo, A. D., Coassin, M., Surico, P. L., & Bonini, S. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109035 · Cited by 21

Pathways to a robust immune response in the elderly

Pawelec, G., Ouyang, Q., Wagner, W., & Wikby, A. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00075-9 · Cited by 21

Anti malondialdehyde-adduct immunological response as a possible marker of successful aging

Traverso, N., Patriarca, S., Balbis, E., Furfaro, A. L., Cottalasso, D., Pronzato, M. A., Carlier, P., Botta, F., Marinari, U. M., & Fontana, L. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00188-8 · Cited by 21

A comprehensive review and recent advancement in the application of tannins for treating Parkinson disease

Satapathy, T., & Kumar, D. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100499 · Cited by 20

Compartmentalized secretory leukocyte protease inhibitor expression and hormone responses along the reproductive tract of postmenopausal women

Kumar, R., Vicari, M., Gori, I., Achtari, C., Fiche, M., Surbeck, I., Damnon, F., & Canny, G. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2011.06.103 · Cited by 19

Long pentraxin PTX3 mediates acute inflammatory responses against pneumococcal infection

Koh, S. H., Shin, S. G., Andrade, M. J., Go, R.-H., Park, S., Woo, C.-H., & Lim, J. H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.133 · Cited by 19

Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors

Gomes, A., Laffón, B., Valdiglesias, V., Gostner, J. M., Felder, T. K., Costa, C., Madureira, J., Fuchs, D., Teixeira, J. P., & Costa, S. (2021) · Antioxidants · doi:10.3390/antiox10121975 · Cited by 19

Clinical implications of addiction related immunosuppression

Reece, A. S. (2008) · Journal of Infection · doi:10.1016/j.jinf.2008.03.003 · Cited by 19

Immunity and aging

Caruso, C., & Vasto, S. (2016) · Encyclopedia of Immunobiology · doi:10.1016/b978-0-12-374279-7.19003-4 · Cited by 18

Mathematical model reveals how regulating the three phases of T‐cell response could counteract immune evasion

Lorenzi, T., Chisholm, R. H., Melensi, M., Lorz, A., & Delitala, M. E. (2015) · Immunology · doi:10.1111/imm.12500 · Cited by 18

Functional and T Cell Receptor Repertoire Analyses of Peripheral Blood and Infrapatellar Fat Pad T Cells in Knee Osteoarthritis

Sae‐jung, T., Sengprasert, P., Apinun, J., Ngarmukos, S., Yuktanandana, P., Tanavalee, A., & Reantragoon, R. (2018) · The Journal of Rheumatology · doi:10.3899/jrheum.170775 · Cited by 19

Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice

Toricelli, M., Evangelista, S. R., Buck, H. S., & Viel, T. A. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00916-0 · Cited by 18

Transforming growth factor-β2 is involved in quantitative genetic variation in thymic involution

Kumar, R., Langer, J., & Snoeck, H. (2005) · Blood · doi:10.1182/blood-2005-04-1495 · Cited by 18

Phenotypic changes with immunosuppression in human recipients

Mueller, T. (2003) · Frontiers in bioscience · doi:10.2741/1182 · Cited by 18

Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways to Age-Related Pathologies and Therapeutic Perspectives

Gromadzka, G., Tarnacka, B., & Cieślik, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010522 · Cited by 19

Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques

Mochan, E., Sego, T. J., Gaona, L., Rial, E., & Ermentrout, B. (2021) · Bulletin of Mathematical Biology · doi:10.1007/s11538-021-00909-0 · Cited by 17

Asthma in the older adult: presentation, considerations and clinical management

Battaglia, S. L., Benfante, A., & Scichilone, N. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.1087850 · Cited by 17

Infection of inbred BALB/c and C57BL/6 and outbred Institute of Cancer Research mice with the emerging H7N9 avian influenza virus

Zhu, Z., Yang, Y., Feng, Y., Shi, B., Chen, L., Zheng, Y., Tian, D., Song, Z., Xu, C., Qin, B., et al. (2013) · Emerging Microbes & Infections · doi:10.1038/emi.2013.50 · Cited by 17

The anti-aging effects of LW-AFCviacorrecting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain

Wang, J., Cheng, X., Zhang, X., Cheng, J., Xu, Y., Ju, Z., Zhou, W., & Zhang, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.8877 · Cited by 17

Medical and biological factors affecting mortality in elderly residential fire victims: a narrative review of the literature

Eggert, E., & Huss, F. R. M. (2017) · Scars Burns & Healing · doi:10.1177/2059513117707686 · Cited by 17

Designing ageing conditions in tumour microenvironment—A new possible modality for cancer treatment

Leibovici, J., Itzhaki, O., Kaptzan, T., Skutelsky, E., Sinai, J., Michowitz, M., Asfur, R., Siegal, A., Huszar, M., & Schiby, G. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.004 · Cited by 17

Changes to Levels of DNA Damage and Apoptotic Resistance in Peripheral Blood Mononuclear Cells and Plasma Antioxidant Potential with Age in Labrador Retriever Dogs

Blount, D. G., Heaton, P. R., & PRITCHARD, D. I. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.2120s · Cited by 17

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

de Mare-Bredemeijer, E., Shi, X., Mancham, S., van Gent, R., van der Heide‐Mulder, M., de Boer, R., Heemskerk, M. H. M., de Jonge, J., van der Laan, L. J. W., Metselaar, H. J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500440 · Cited by 18

Insulin-like growth factor-I (IGF-I) and its association with lymphocyte homeostasis in the ageing cat

CAMPBELL, D. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.05.002 · Cited by 18

Long‐term persistence and recall of immune responses in aged mice after mucosal immunization

Harrod, T., Martin, M., & Russell, M. W. (2001) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.2001.016003170.x · Cited by 17

Inflammation, Infiltration, and Evasion—Tumor Promotion in the Aging Breast

Cruz-Reyes, N., & Radisky, D. C. (2023) · Cancers · doi:10.3390/cancers15061836 · Cited by 16

Age and facial nerve axotomy-induced T cell trafficking: Relation to microglial and motor neuron status

Dauer, D. J., Huang, Z. L., Ha, G. K., Kim, J., Khosrowzadeh, D., & Petitto, J. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.08.005 · Cited by 17

Age-dependent differences in the efficacy of cancer immunotherapy in C57BL and AKR mouse strains

Kaptzan, T., Skutelsky, E., Itzhaki, O., Sinai, J., Michowitz, M., Yossipov, Y., Schiby, G., & Leibovici, J. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.03.035 · Cited by 16

Immune Checkpoint Inhibitors: The Unexplored Landscape of Geriatric Oncology

Choucair, K., Naqash, A. R., Nebhan, C. A., Nipp, R. D., Johnson, D. B., & Saeed, A. (2022) · The Oncologist · doi:10.1093/oncolo/oyac119 · Cited by 15

Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study

Echarri, A. A., Struszczak, L., Beresford, M. J., Campbell, J. P., Jones, R. H., Thompson, D., & Turner, J. E. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1107070 · Cited by 15

CD57 T cells associated with immunosenescence in adults living with HIV or AIDS

Júnior, E. E., Gubert, V. T., Jacob, C. M. B., Puga, M. A. M., Gouveia, C. G., Sichinel, Â. H., & Tozetti, I. A. (2023) · Immunology · doi:10.1111/imm.13707 · Cited by 15

Discrete Dynamical Modeling of Influenza Virus Infection Suggests Age-Dependent Differences in Immunity

Mochan, E., Zhang, L. A., Swigon, D., Urbano, A., Ermentrout, B., Matuszewski, M., Toapanta, F. R., Ross, T. M., Parker, R. S., & Clermont, G. (2017) · Journal of Virology · doi:10.1128/jvi.00395-17 · Cited by 15

Aging and the Krüppel-like factors.

Hsieh, P. N., Sweet, D. R., Fan, L., & Jain, M. K. (2017) · PubMed · Cited by 15

Insights from a Case of Good’s Syndrome (Immunodeficiency with Thymoma)

Paganelli, R., Lizia, M. D., D’Urbano, M., Gatta, A., Paganelli, A., Amerio, P., & Parronchi, P. (2023) · Biomedicines · doi:10.3390/biomedicines11061605 · Cited by 15

Aging and immune response in chronic human schistosomiasis

Comin, F., Speziali, E., Corrêa‐Oliveira, R., & Faria, A. M. C. (2008) · Acta Tropica · doi:10.1016/j.actatropica.2008.05.004 · Cited by 15

The influence of vitamin E on immune function and response to vaccination in older horses1

Petersson, K. H., Burr, D. B., Marta Gómez-chiarri, G., & Petersson‐Wolfe, C. S. (2010) · Journal of Animal Science · doi:10.2527/jas.2008-1724 · Cited by 15

Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study

Ahmadi-Abhari, S., Kaptoge, S., Luben, R. N., Wareham, N. J., & Khaw, K.-T. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0224-1 · Cited by 14

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Kong, X., Hu, R., Zhang, P., Li, Q., Song, K., Gu, H., Zheng, J., Liu, S., Liu, L., Jin, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202507178 · Cited by 15

Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old

Katsel, P., & Haroutunian, V. H. (2019) · Phlebolymphology · doi:10.31887/dcns.2019.21.1/vharoutunian · Cited by 14

Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia

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