Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood

Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709

Increased cytokine production in mononuclear cells of healthy elderly people

Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665

The immunology of exceptional individuals: the lesson of centenarians

Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

Fagnoni, F. F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., Casti, A., Franceschi, C., Passeri, M., & Sansoni, P. (2000) · Blood · doi:10.1182/blood.v95.9.2860.009k35_2860_2868 · Cited by 515

Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians [see comments]

Sansoni, P., Cossarizza, A., Brianti, V., Fagnoni, F. F., Snelli, G., Monti, D., Marcato, A., Passeri, G., Ortolani, C., & Forti, E. (1993) · Blood · doi:10.1182/blood.v82.9.2767.2767 · Cited by 457

The Aging Thyroid

MARIOTTI, S., FRANCESCHI, C., COSSARIZZA, A., & PINCHERA, N. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-6-686 · Cited by 449

Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians

FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-689.x · Cited by 362

Aging and Cancer: The Double‐Edged Sword of Replicative Senescence

Campisi, J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb05175.x · Cited by 254

CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory

Cossarizza, A., Ortolani, C., Paganelli, R., Barbieri, D., Monti, D., Sansoni, P., Fagiolo, U., Castellani, G., Bersani, F., Londei, M., et al. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01691-0 · Cited by 253

Thyroid and other organ-specific autoantibodies in healthy ceritenarians

Mariotti, S., Barbesino, G., Caturegli, P., Giacomelli, T., Pinchera, A., Monti, D., Cossarizza, A., Franceschi, C., Sansoni, P., Passeri, G., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)91265-a · Cited by 227

Rejection and recipient age

BRADLEY, B. A. (2002) · Transplant Immunology · doi:10.1016/s0966-3274(02)00058-8 · Cited by 95

Inflamm‐aging of the stem cell niche: Breast cancer as a paradigmatic example

Bonafè, M., Storci, G., & Franceschi, C. (2011) · BioEssays · doi:10.1002/bies.201100104 · Cited by 96

Immunotherapy in Older Adults With Advanced Cancers: Implications for Clinical Decision-Making and Future Research

Kanesvaran, R., Córdoba, R., & Maggiore, R. J. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_201435 · Cited by 92

Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system

van Baarle, D., Tsegaye, A., Miedema, F. F., & Akbar, A. N. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.10.003 · Cited by 91

Immunological outcomes of exercise in older adults

Senchina, D. S., & Kohut, M. L. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.3 · Cited by 91

Dendritic cells and aging: consequences for autoimmunity

Agrawal, A., Sridharan, A., Prakash, S., & Agrawal, H. (2011) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.77 · Cited by 90

The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects

Namas, R. A., Ghuma, A., Hermus, L., Zamora, R., Okonkwo, D., Billiar, T., & Yoram Vodovotz, B. (2009) · Libyan Journal of Medicine · doi:10.4176/090325 · Cited by 89

Changes in peripheral blood immune cell composition in osteoarthritis

Ponchel, F., Burska, A. N., Hensor, E. M. A., Raja, R., Campbell, M., Emery, P., & Conaghan, P. G. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.06.018 · Cited by 88

Aging and the pathogenic response to burn.

Rani, M., & Schwacha, M. G. (2012) · Europe PMC (PubMed Central) · Cited by 87

Neuroinflammation and the genetics of Alzheimer’s disease: The search for a pro-inflammatory phenotype

Franceschi, C., Valensin, S., Lescai, F., Olivieri, F., Licastro, F., Grimaldi, L. M. E., Monti, D., BENEDICTIS, G. D., & Bonafè, M. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351475 · Cited by 87

Immunoproteasomes and immunosenescence

Mishto, M., Santoro, A., Bellavista, E., Bonafè, M., Monti, D., & Franceschi, C. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00030-8 · Cited by 86

Age, parasites, and condition affect humoral immune response in tropical pythons

Újvári, B., & Madsen, T. R. L. (2005) · Behavioral Ecology · doi:10.1093/beheco/ari091 · Cited by 86

Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians

Monti, D., Salvioli, S., Capri, M., Malorni, W., Straface, E., Cossarizza, A., Botti, B., Piacentini, M., Baggio, G., Barbi, C., et al. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00220-7 · Cited by 86

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki, E., Schönknecht, P., Hossini, A. M., Kaiser, E., Katsouli, M.-M., Adjaye, J., Schröder, J., & Zouboulis, C. C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.005 · Cited by 88

Immune receptor signaling, aging, and autoimmunity

Hasler, P., & Zouali, M. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.04.012 · Cited by 84

Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: A Reflection by Cerebrospinal Fluid Biomarkers

Khademi, M., Dring, A. M., Gilthorpe, J. D., Wuolikainen, A., Nimer, F. A., Harris, R. A., Andersson, M., Brundin, L., Piehl, F., Olsson, T. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063172 · Cited by 85

The extreme longevity: The state of the art in Italy

Franceschi, C., Motta, L., Motta, M., Malaguarnera, M., Capri, M., Vasto, S., Candore, G., & Caruso, C. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.006 · Cited by 83

Senescence of the cellular immune response in Drosophila melanogaster

Mackenzie, D. K., Bussière, L. F., & Tinsley, M. C. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.07.004 · Cited by 83

A novel B cell population revealed by a CD38/CD24 gating strategy: CD38−CD24− B cells in centenarian offspring and elderly people

Buffa, S., Pellicanò, M., Bulati, M., Martorana, A., Goldeck, D., Caruso, C., Pawelec, G., & Colonna‐Romano, G. (2012) · AGE · doi:10.1007/s11357-012-9488-5 · Cited by 83

Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro

Liang, S., Domon, H., Hosur, K. B., Wang, M., & Hajishengallis, G. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.006 · Cited by 81

Changes in Adipose Tissue Macrophages and T Cells During Aging

Garg, S. K., Delaney, C. E., Shi, H., & Yung, R. L. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013006833 · Cited by 82

Complexity of Anti‐immunosenescence Strategies in Humans

Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L., et al. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00295.x · Cited by 81

Age as an independent risk factor for severity of experimental choroidal neovascularization.

Espinosa‐Heidmann, D. G., Suñer, I. J., Hernandez, E. P., Frazier, W. D., Csaky, K. G., & Cousins, S. W. (2002) · PubMed · Cited by 81

Immunomodulating effect of influenza vaccination in the elderly differing in health status

Myśliwska, J. M., Trzonkowski, P., Szmit, E., Brydak, L. B., Machała, M. K., & Myśliwski, A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.005 · Cited by 79

Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers

Reece, A. S. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-6 · Cited by 81

Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study

Ahmadi‐Abhari, S., Luben, R., Wareham, N. J., & Khaw, K. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9819-6 · Cited by 78

Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

Colitti, M., Stefanon, B., Gabai, G., Gelain, M. E., & Bonsembiante, F. (2019) · Antioxidants · doi:10.3390/antiox8010028 · Cited by 78

Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview

Cakala, M., Kołodziej, P., & Puzianowska‐Kuźnicka, M. (2021) · Cells · doi:10.3390/cells10113148 · Cited by 81

Immune responses of bumblebee workers as a function of individual and colony age: senescence versus plastic adjustment of the immune function

Moret, Y., & Schmid‐Hempel, P. (2009) · Oikos · doi:10.1111/j.1600-0706.2008.17187.x · Cited by 77

Genes, ageing and longevity in humans: Problems, advantages and perspectives

Salvioli, S., Olivieri, F., Marchegiani, F., Cardelli, M., Santoro, A., Bellavista, E., Mishto, M., Invidia, L., Capri, M., Valensin, S., et al. (2006) · Free Radical Research · doi:10.1080/10715760600917136 · Cited by 77

Mitochondrial DNA involvement in human longevity

Santoro, A., Salvioli, S., Raule, N., Capri, M., Sevini, F., Valensin, S., Monti, D., Bellizzi, D., Passarino, G., Rose, G., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.040 · Cited by 76

Infections in the Elderly

Liang, S. Y., & Mackowiak, P. A. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2007.01.010 · Cited by 77

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection

Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00784 · Cited by 74

T cells in idiopathic pulmonary fibrosis: crucial but controversial

Deng, L., Huang, T., & Zhang, L. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01344-x · Cited by 78

Bioactive Nutrients and Nutrigenomics in Age-Related Diseases

Rescigno, T., Micolucci, L., Tecce, M. F., & Capasso, A. (2017) · Molecules · doi:10.3390/molecules22010105 · Cited by 75

Terminally Differentiated CD8+ Temra Cells Are Associated With the Risk for Acute Kidney Allograft Rejection

Betjes, M. G. H., Meijers, R. W. J., de Wit, E. A., Weimar, W. W., & Litjens, N. H. R. (2012) · Transplantation · doi:10.1097/tp.0b013e31825306ff · Cited by 73

Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?

Gangemi, S. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00061-5 · Cited by 73

Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence

Lang, P.-O., Mitchell, W. A., Lapenna, A., Pitts, D. G., & Aspinall, R. (2010) · European Geriatric Medicine · doi:10.1016/j.eurger.2010.01.010 · Cited by 75

Biomarkers of the ageing immune system and their association with frailty – A systematic review

Hoi, E. T. V., de Glas, N. A., Portielje, J. E. A., van Heemst, D., van den Bos, F., Jochems, S. P., & Mooijaart, S. P. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112163 · Cited by 72

Is Regular Exercise a Friend or Foe of the Aging Immune System? A Systematic Review

Haaland, D. A., Sabljic, T. F., Baribeau, D. A., Mukovozov, I., & Hart, L. E. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181865eec · Cited by 71

Towards a Liquid Self: How Time, Geography, and Life Experiences Reshape the Biological Identity

Grignolio, A., Mishto, M., Faria, A. M. C., Garagnani, P., Franceschi, C., & Tieri, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00153 · Cited by 73

Memory B Cell Subpopulations in the Aged

Colonna‐Romano, G., Aquino, A., Bulati, M., Lorenzo, G. D., Listı̀, F., Vitello, S., Lio, D., Candore, G., Clesi, G., & Caruso, C. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.149 · Cited by 70

Aging of the hematopoietic system

Snoeck, H. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283623c77 · Cited by 73

Inflammation, genetic background and longevity

Candore, G., Caruso, C., & Colonna‐Romano, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9286-3 · Cited by 69

Biomarkes of aging

Caruso, C. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s72 · Cited by 68

Immunosenescence patterns differ between populations but not between sexes in a long-lived mammal

Cheynel, L., Lemaître, J., Gaillard, J., Rey, B., Bourgoin, G., Ferté, H., Jégo, M., Débias, F., Pellerin, M., Jacob, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13686-5 · Cited by 68

Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells

Trzonkowski, P., Dębska-Ślizień, A. M., Jankowska, M., Wardowska, A., Carvalho‐Gaspar, M., Hak, Ł., Moszkowska, G., Bzoma, B., Mills, N., Wood, K. J., et al. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.006 · Cited by 68

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

Moreau, J.-F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J.-L., Garagnani, P., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.005 · Cited by 67

Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Capri, M., Salvioli, S., Monti, D., Caruso, C., Candore, G., Vasto, S., Olivieri, F., Marchegiani, F., Sansoni, P., Baggio, G., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.004 · Cited by 65

Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?

Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 66

Chronic antigenic load and apoptosis in immunosenescence

Ginaldi, L., Martinis, M. D., Monti, D., & Franceschi, C. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.11.005 · Cited by 65

From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly

Trzonkowski, P., Myśliwska, J. M., Pawelec, G., & Myśliwski, A. (2008) · Biogerontology · doi:10.1007/s10522-008-9155-5 · Cited by 64

B Cell Immunosenescence in the Elderly and in Centenarians

Colonna‐Romano, G., Bulati, M., Aquino, A., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0664 · Cited by 59

The Acute Inflammatory Response in Trauma /Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects

Namas, R. A., Ghuma, A., Hermus, L., Zamora, R., Okonkwo, D., Billiar, T., & Yoram Vodovotz, B. (2008) · Libyan Journal of Medicine · doi:10.3402/ljm.v4i3.4824 · Cited by 60

Variation Rhythms of Lymphocyte Subsets during Healthy Aging

Faria, A. M. C., de Moraes, S. M., de Freitas, L. H. F., Speziali, E., Soares, T. F., Neves, S. P. F., Vitelli-Avelar, D. M., Martins, M. Â., Barbosa, K. V. B. D., Soares, E. B., et al. (2008) · NeuroImmunoModulation · doi:10.1159/000156478 · Cited by 59

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

Panickar, K. S., & Jewell, D. E. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0017 · Cited by 58

Developments in molecular epidemiology of aging

Hägg, S., Belsky, D. W., & Cohen, A. A. (2019) · Emerging Topics in Life Sciences · doi:10.1042/etls20180173 · Cited by 58

Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics

Pujos‐Guillot, E., Pétéra, M., Jacquemin, J., Centeno, D., Lyan, B., Montoliu, I., Madej, D., Pietruszka, B., Fabbri, C., Santoro, A., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01903 · Cited by 57

Immunosenescence and lymphomagenesis

Mancuso, S., Carlisi, M., Santoro, M., Napolitano, M., Raso, S., & Siragusa, S. M. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0130-y · Cited by 54

Phagocytosis by invertebrate hemocytes: Causes of individual variation in Panorpa vulgaris scorpionflies

Kurtz, J. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10099 · Cited by 54

Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

Litjens, N. H. R., de Wit, E. A., & Betjes, M. G. H. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-2 · Cited by 54

The trajectory of life. Decreasing physiological network complexity through changing fractal patterns

Sturmberg, J. P., Bennett, J. M., Picard, M. A., & SEELY, A. J. E. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00169 · Cited by 54

Do natural antibodies compensate for humoral immunosenescence in tropical pythons?

Újvári, B., & Madsen, T. R. L. (2011) · Functional Ecology · doi:10.1111/j.1365-2435.2011.01860.x · Cited by 53

The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old

Bonafè, M., Valensin, S., Gianni, W., Marigliano, V., & Franceschi, C. (2001) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00168-8 · Cited by 53

Expansion of peripheral CD8+ CD28- T cells in response to Epstein-Barr virus in patients with rheumatoid arthritis.

Klatt, T., Ouyang, Q., Flad, T., Koetter, I., Bühring, H., Kalbacher, H., Pawelec, G., & Müller, C. A. (2005) · PubMed · Cited by 53

DNA damage in aging, the stem cell perspective

McNeely, T., Leone, M., Yanai, H., & Beerman, I. (2020) · Human Genetics · doi:10.1007/s00439-019-02047-z · Cited by 52

Measurement of cell-mediated immunity with a varicella-zoster virus-specific interferon-? ELISPOT assay: Responses in an elderly population receiving a booster immunization

Smith, J. G., Levin, M. J., Vessey, R., Chan, I. S. F., Hayward, A. R., Liu, X., Kaufhold, R. M., Clair, J. S., Chalikonda, I., Chan, C. Y., et al. (2003) · Journal of Medical Virology · doi:10.1002/jmv.10318 · Cited by 52

The immune system in the aging human

Rymkiewicz, P. D., Heng, Y. X., Vasudev, A., & Larbi, A. (2012) · Immunologic Research · doi:10.1007/s12026-012-8289-3 · Cited by 50

Immune Profile Predicts Survival and Reflects Senescence in a Small, Long-Lived Mammal, the Greater Sac-Winged Bat (Saccopteryx bilineata)

Schneeberger, K., Courtiol, A., Czirják, G. Á., & Voigt, C. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108268 · Cited by 51

ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications

Ducloux, D., Legendre, M., Bamoulid, J., Rebibou, J.-M., Saas, P., Courivaud, C., & Crépin, T. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0121-z · Cited by 49

Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells

Bowyer, G., Sharpe, H., Venkatraman, N., Ndiaye, P. B., Wade, D., Brenner, N., Mentzer, A. J., Mair, C., Waterboer, T., Lambe, T., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200004 · Cited by 52

Effect of Resistance Training on Immunological Parameters of Healthy Elderly Women

Raso, V., Benard, G., Duarte, A. J. D. S., & Natale, V. M. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318156e9fa · Cited by 48

The effect of age and telomere length on immune function in the horse

Katepalli, M. P., Adams, A. A., Lear, T. L., & Horohov, D. W. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.06.007 · Cited by 47

Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation

Dedeoğlu, B., Meijers, R. W. J., Klepper, M., Hesselink, D. A., Baan, C. C., Litjens, N. H. R., & Betjes, M. G. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150826 · Cited by 46

Diffuse Large B-cell Lymphoma in the elderly: standard treatment and new perspectives

Chiappella, A., Castellino, A., Nicolosi, M., Santambrogio, E., & Vitolo, U. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1305264 · Cited by 46

Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination

Kennedy, R. B., Ovsyannikova, I. G., Haralambieva, I. H., Oberg, A. L., Zimmermann, M. T., Grill, D. E., & Poland, G. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00450 · Cited by 45

Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls

Booiman, T., Wit, F. W. N. M., Girigorie, A. F., Maurer, I., Francesco, D. D., Sabin, C. A., Harskamp, A. M., Prins, M., Franceschi, C., Deeks, S. G., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183357 · Cited by 45

Immunosenescence of the Equine Immune System

Horohov, D. W., Adams, A. A., & Chambers, T. M. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.10.007 · Cited by 45

Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes

Pellegrina, D. V. D. S., Severino, P., Barbeiro, H. V., Andreghetto, F. M., Velasco, I. T., de Souza, H. P., Machado, M. C. C., Reis, E. M. R., & da Silva, F. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128341 · Cited by 46

Can the Immune System Still Be Efficient in the Elderly? An Immunological and Immunoendocrine Therapeutic Perspective

Pfister, G., & Savino, W. (2008) · NeuroImmunoModulation · doi:10.1159/000156477 · Cited by 44

Telomeres, Aging and Exercise: Guilty by Association?

Chilton, W., O’Brien, B. J., & Charchar, F. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122573 · Cited by 44

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Hunt, K. J., Walsh, B. M., Voegeli, D., & Roberts, H. C. (2009) · Biological Research For Nursing · doi:10.1177/1099800409352237 · Cited by 42

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Vasto, S., & Caruso, C. (2004) · Immunity & Ageing · doi:10.1186/1742-4933-1-1 · Cited by 40

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