Cited by 449Thyroid Disorders and TreatmentsHormonal and reproductive studiesThyroid Cancer Diagnosis and Treatment

The Aging Thyroid

MARIOTTI, STEFANO, FRANCESCHI, CLAUDIO, COSSARIZZA, ANDREA, PINCHERA, NDALDO·1995·Endocrine Reviews

Abstract

THE number and proportion of elderly people are steadily growing in western societies as a consequence of increased life expectancy and reduced birth rate. This phenomenon has important social, economical, and public health implications and has generated a number of studies aimed at clarifying the basis of the physiological and pathological aspects of aging. In this context, endocrine function in the elderly has been the object of particular attention (1–9). An important concept derived from these studies is that while the equilibrium concentrations of the principal hormones are substantially normal in most healthy elderly, with advancing age there are significant alterations in hormone production, metabolism, and action, with consequent achievement of new equilibria. As proposed by Mooradian et al. (4), aging may be defined as a time of reduced adaptability to metabolic perturbation. It has been repeatedly suggested that some of these changes may play a role in the pathophysiology of senescence, but the evidence for this is still very limited. The thyroid gland plays an important and specific role in the relationships between the endocrine system and aging (10–22). First, it is well recognized that symptoms of aging can easily be confused with hypothyroidism, and in the past decreased thyroid function was believed to be one of the hallmarks of the aging process (14,16). Second, thyroid diseases are common in the elderly, but their clinical manifestations are frequently different from those seen in younger patients; they are more subtle and often hidden by a background of intercurrent disease.

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Crossref · 10.1210/edrv-16-6-686

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Authors
MARIOTTI, S., FRANCESCHI, C., COSSARIZZA, A., & PINCHERA, N.
Affiliations
University of Pisa (IT)
Corresponding author
MARIOTTI, STEFANO
Venue
Endocrine Reviews
Published
1995-12
Volume
16
Issue
6
Pages
686-715
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W1989926032
Cited by
449
References
0
Citations by year
2026: 5 · 2025: 6 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 14 · 2020: 6 · 2019: 19 · 2018: 18 · 2017: 16 · 2016: 20 · 2015: 16 · 2014: 20 · 2013: 31 · 2012: 25
FWCI
7.90
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
older adults, hypothyroidism, thyroid function, endocrine aging, senescence, hormone metabolism
MeSH terms
Aged, Aging, Animals, Humans, Reference Values, Thyroid Diseases, Thyroid Gland, Autoimmunity

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