The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
Abstract
According to the remodeling theory of aging we proposed several years ago, the current data on human immunosenescence depicts a complex scenario where clonotypical immunity deteriorates, while ancestral innate/natural immunity is largely conserved or even up-regulated with age. Under an evolutionary perspective, antigens are the cause of a persistent life-long antigenic stress, responsible for the accumulation of effector CD8+/CD28- T cells, the decrease of naive T cells (CD95-) and the marked shrinkage of T cell repertoire with age. Concomitantly, NK cytotoxicity, chemotaxis, phagocytosis and complement activities remain unaffected or negligibly affected, in comparison to clonotypical immunity. Thus, immunosenescence is not a random deteriorative phenomenon but appears to inversely recapitulate an evolutionary pattern. On the whole, immunosenescence can be envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of potential antigens (viruses, bacteria, but also food and self molecules among others). From this perspective antigens are nothing else than a particular type of stressor and immunosenescence appears to be the price paid to immunological memory, i.e. one of the main characteristics of the most evolutionary recent and sophisticated type of immunity. Together with the age-related thymic involution, and the consequent age-related decrease of thymic output of new T cells, this situation leaves the body practically devoid of virgin T cells, and thus likely more prone to a variety of infectious and non infectious diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As previously stated, an age-related decrease in absolute number of peripheral blood naïve T cells is consistently found in all studies and in different human populations (22, 37).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [37]
In the citing paper
“A variety of phenomena have been proposed to contribute to this age-related heightened inflammatory state including redox stress [46], immuno- and endocrine senescence [47, 48], DNA damage [49], epigenetic modification [50], and a distortion of gut microbial homeostasis [51] that is associated with increased levels of circulating endotoxin [42].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [47]
Citations
Cites
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665
Self-citationThe immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
Self-citationShortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
Fagnoni, F. F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., Casti, A., Franceschi, C., Passeri, M., & Sansoni, P. (2000) · Blood · doi:10.1182/blood.v95.9.2860.009k35_2860_2868 · Cited by 515
Self-citationSansoni, P., Cossarizza, A., Brianti, V., Fagnoni, F. F., Snelli, G., Monti, D., Marcato, A., Passeri, G., Ortolani, C., & Forti, E. (1993) · Blood · doi:10.1182/blood.v82.9.2767.2767 · Cited by 457
MARIOTTI, S., FRANCESCHI, C., COSSARIZZA, A., & PINCHERA, N. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-6-686 · Cited by 449
Self-citationExpansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians
FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-689.x · Cited by 362
Self-citationAging and Cancer: The Double‐Edged Sword of Replicative Senescence
Campisi, J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb05175.x · Cited by 254
Cossarizza, A., Ortolani, C., Paganelli, R., Barbieri, D., Monti, D., Sansoni, P., Fagiolo, U., Castellani, G., Bersani, F., Londei, M., et al. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01691-0 · Cited by 253
Self-citationThyroid and other organ-specific autoantibodies in healthy ceritenarians
Mariotti, S., Barbesino, G., Caturegli, P., Giacomelli, T., Pinchera, A., Monti, D., Cossarizza, A., Franceschi, C., Sansoni, P., Passeri, G., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)91265-a · Cited by 227
Self-citation
Cited by
Sorted by citations
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Self-citationChronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Self-citationFranceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Self-citationInflammation and immune dysfunction in Parkinson disease
Tansey, M. G., Wallings, R. L., Houser, M. C., Herrick, M. K., Keating, C. E., & Joers, V. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00684-6 · Cited by 1,382
Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997
Self-citationThe aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Campbell, J. P., & Turner, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00648 · Cited by 736
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603
Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581
Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity
Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.02.055 · Cited by 495
Self-citationInflammatory networks in ageing, age-related diseases and longevity
Vasto, S., Candore, G., Balistreri, C. R., Caruso, M., Colonna‐Romano, G., Grimaldi, M. P., Listı̀, F., Nuzzo, D., Lio, D., & Caruso, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.015 · Cited by 481
Immunology of aging: the birth of inflammaging
Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464
Self-citationThe Immunopathogenesis of Sepsis in Elderly Patients
Opal, S. M., Girard, T. D., & Ely, E. W. (2005) · Clinical Infectious Diseases · doi:10.1086/432007 · Cited by 461
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
Iskander, K. N., Osuchowski, M. F., Stearns-Kurosawa, D. J., Kurosawa, S., Stepien, D. M., Valentine, C., & Remick, D. G. (2013) · Physiological Reviews · doi:10.1152/physrev.00037.2012 · Cited by 470
The immune system and aging: A review
Castelo-Branco, C., & Soveral, I. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.852531 · Cited by 449
The immune system in extreme longevity
Sansoni, P., Vescovini, R., Fagnoni, F. F., Biasini, C., Zanni, F., Zanlari, L., Telera, A. R., Lucchini, G., Passeri, G., Monti, D., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.008 · Cited by 442
Self-citationInsights into thymic aging and regeneration
Taub, D. D., & Longo, D. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00275.x · Cited by 399
Grosicki, G. J., Fielding, R. A., & Lustgarten, M. S. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0345-5 · Cited by 388
Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?
Franceschi, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00358.x · Cited by 342
Self-citationInflammation markers predicting frailty and mortality in the elderly
Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.11.004 · Cited by 349
Self-citationThe network and the remodeling theories of aging: historical background and new perspectives
Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D., & De Benedictis, G. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00172-8 · Cited by 335
Self-citationImmune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
Peterson, C. T., Sharma, V., Elmén, L., & Peterson, S. N. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12474 · Cited by 325
Aging of the Immune System as a Prognostic Factor for Human Longevity
Larbi, A., Franceschi, C., Mazzatti, D. J., Solana, R., Wikby, A., & Pawelec, G. (2008) · Physiology · doi:10.1152/physiol.00040.2007 · Cited by 316
Self-citationCD57 in human natural killer cells and T-lymphocytes
Kared, H., Martelli, S., Ng, T. P., Pender, S. L. F., & Larbi, A. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1803-z · Cited by 318
Ageing of lymphocytes and lymphocytes in the aged
Globerson, A., & Effros, R. B. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01714-x · Cited by 313
Social reversal of immunosenescence in honey bee workers
Amdam, G. V., Aase, A. L. T. O., Seehuus, S., Fondrk, M. K., Norberg, K., & Hartfelder, K. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.004 · Cited by 292
Franceschi, C., Salvioli, S., Garagnani, P., de Eguileor, M., Monti, D., & Capri, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00982 · Cited by 290
Self-citationExercise and the aging immune system
Simpson, R. J., Lowder, T. W., Spielmann, G., Bigley, A. B., LaVoy, E. C., & Kunz, H. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.003 · Cited by 281
Kovacs, E. J., Lowery, E. M., Kuhlmann, E. A., & Brubaker, A. L. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s51152 · Cited by 292
Colonna-Romano, G., Bulati, M., Aquino, A., Pellicanò, M., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.08.003 · Cited by 270
Hanania, N. A., King, M. J., Braman, S. S., Saltoun, C. A., Wise, R. A., Enright, P., Falsey, A. R., Mathur, S. K., Ramsdell, J., Rogers, L., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.048 · Cited by 267
Do men and women follow different trajectories to reach extreme longevity?
Franceschi, C., Motta, L., Valensin, S., Rapisarda, R., Franzone, A., Berardelli, M., Motta, M., Monti, D., Bonafè, M., Ferrucci, L., et al. (2000) · Aging Clinical and Experimental Research · doi:10.1007/bf03339894 · Cited by 256
Self-citationSalvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E., & Franceschi, C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947470 · Cited by 240
Self-citationOuyang, Q., Wagner, W. M., Wikby, A., Walter, S., Aubert, G., Dodi, A. I., Travers, P. J., & Pawelec, G. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1024580531705 · Cited by 239
Ouyang, Q., Wagner, W. M., Voehringer, D., Wikby, A., Klatt, T., Walter, S., Müller, C. A., Pircher, H., & Pawelec, G. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00134-7 · Cited by 238
Immune System Dysfunction in the Elderly
Eduardo Fuentes, Q., FUENTES, M., Alarcón, M. A., & Palomo, I. F. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160487 · Cited by 242
Stout, R. D., & Suttles, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00260.x · Cited by 224
Franceschi, C., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Capri, M., Salvioli, S., Valensin, S., Benedictis, G. D., Iorio, A. D., et al. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.028 · Cited by 211
Self-citationMoynihan, J. A., Chapman, B. P., Klorman, R., Krasner, M. S., Duberstein, P. R., Brown, K. W., & Talbot, N. L. (2013) · Neuropsychobiology · doi:10.1159/000350949 · Cited by 210
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.004 · Cited by 210
Self-citationImmune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219531 · Cited by 209
Self-citationThe Immune System in the Elderly: Activation-Induced and Damage-Induced Apoptosis
Ginaldi, L., Martinis, M. D., Monti, D., & Franceschi, C. (2004) · Immunologic Research · doi:10.1385/ir:30:1:081 · Cited by 202
Self-citationRole of CMV in immune senescence.
Pawelec, G., & Derhovanessian, E. (2011) · Virus Research · doi:10.1016/j.virusres.2010.09.010 · Cited by 201
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
Zekavat, S. M., Lin, S., Bick, A. G., Liu, A., Paruchuri, K., Wang, C., Uddin, M. M., Ye, Y., Yu, Z., Liu, X., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01371-0 · Cited by 202
Insights into Severe Sepsis in Older Patients: From Epidemiology to Evidence-Based Management
Girard, T. D., Opal, S. M., & Ely, E. W. (2005) · Clinical Infectious Diseases · doi:10.1086/427876 · Cited by 202
Dietary antiaging phytochemicals and mechanisms associated with prolonged survival
Si, H., & Liu, D. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.02.001 · Cited by 201
Human models of aging and longevity
Cevenini, E., Invidia, L., Lescai, F., Salvioli, S., Tieri, P., Castellani, G., & Franceschi, C. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.9.1393 · Cited by 200
Self-citationThe surgical management of elderly cancer patients
Audisio, R. A., Bozzetti, F., Gennari, R., Jaklitsch, M. T., Koperna, T., Longo, W. E., Wiggers, T., & Zbar, A. P. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.01.016 · Cited by 196
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 192
Immunosenescence and Immunogenetics of Human Longevity
Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 189
Self-citationApoptosis and other immune biomarkers predict influenza vaccine responsiveness
Furman, D., Jojic, V., Kidd, B., Shen‐Orr, S., Price, J., Jarrell, J., Tse, T., Huang, H., Lund, P., Maecker, H. T., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.15 · Cited by 184
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People
Pietrobon, A. J., Teixeira, F. M. E., & Sato, M. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579220 · Cited by 187
Senescence of the Human Immune System
Pawelec, G., Larbi, A., & Derhovanessian, E. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.09.005 · Cited by 180
Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly
Ouyang, Q., Wagner, W. M., Zheng, W., Wikby, A., Remarque, E. J., & Pawelec, G. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.016 · Cited by 179
The Etiology and Epidemiology of Merkel Cell Carcinoma
Agelli, M., Clegg, L. X., Becker, J. C., & Rollison, D. E. M. (2010) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2010.01.001 · Cited by 176
Premature ageing of the immune system: the cause of AIDS?
Appay, V., & Rowland-Jones, S. L. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02338-4 · Cited by 173
The Role of Stress Factors during Aging of the Immune System
Bauer, M. E., Jeckel, C. M. M., & Luz, C. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03966.x · Cited by 174
Inflammaging and human longevity in the omics era
Monti, D., Ostan, R., Borelli, V., Castellani, G., & Franceschi, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.008 · Cited by 169
Self-citationInflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges
Wyczałkowska-Tomasik, A., Czarkowska‐Pączek, B., Zielenkiewicz, M., & Pączek, L. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0357-7 · Cited by 165
DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
Olivieri, F., Albertini, M. C., Orciani, M., Ceka, A., Cricca, M., Procopio, A. D., & Bonafè, M. (2015) · Oncotarget · doi:10.18632/oncotarget.5899 · Cited by 163
Self-citationImmunosenenescence: role of cytomegalovirus
Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163
Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians
Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., et al. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00195-0 · Cited by 162
Self-citationAge-related changes in immunity: implications for vaccination in the elderly
Kovaiou, R. D., Herndler‐Brandstetter, D., & Grubeck‐Loebenstein, B. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000221 · Cited by 160
Influenza vaccine responses in older adults
McElhaney, J. E. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.008 · Cited by 155
Age‐associated B cells: key mediators of both protective and autoreactive humoral responses
Naradikian, M. S., Hao, Y., & Cancro, M. P. (2015) · Immunological Reviews · doi:10.1111/imr.12380 · Cited by 157
Zolla, V., Nizamutdinova, I. T., Scharf, B., Clement, C. C., Maejima, D., Akl, T. J., Nagai, T., Luciani, P., Leroux, J., Halin, C., et al. (2015) · Aging Cell · doi:10.1111/acel.12330 · Cited by 155
Low zinc status: a new risk factor for pneumonia in the elderly?
Barnett, J. B., Hamer, D. H., & Meydani, S. N. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00253.x · Cited by 149
Regulation of aging and innate immunity in C. elegans
Kurz, C. L., & Tan, M. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00108.x · Cited by 145
Listı̀, F., Candore, G., Modica, M. A., Russo, M., Lorenzo, G. D., Esposito-Pellitteri, M., Colonna‐Romano, G., Aquino, A., Bulati, M., Lio, D., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.013 · Cited by 140
Self-citationThe potential role of necroptosis in inflammaging and aging
Royce, G. H., Brown‐Borg, H. M., & Deepa, S. S. (2019) · GeroScience · doi:10.1007/s11357-019-00131-w · Cited by 137
Meyer, K. C. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200508-081js · Cited by 136
Gaillard, J., & Lemaître, J. (2017) · Evolution · doi:10.1111/evo.13379 · Cited by 137
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129
Immunogenetics, Gender, and Longevity
Candore, G., Balistreri, C. R., Listı̀, F., Grimaldi, M. P., Vasto, S., Colonna‐Romano, G., Franceschi, C., Lio, D., Caselli, G., & Caruso, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.051 · Cited by 129
Self-citationTrzonkowski, P., Zilvetti, M., Chapman, S. J., Więckiewicz, J., Sutherland, A., Friend, P. J., & Wood, K. J. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02078.x · Cited by 128
Physical activity, immunity and infection
Romeo, J., Wärnberǵ, J., Pozo, T., & Marcos, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001795 · Cited by 128
Challenges with Diagnosing and Managing Sepsis in Older Adults
Clifford, K. M., Dy‐Boarman, E. A., Haase, K. K., Maxvill, K., Pass, S. E., & Álvarez, C. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2016.1135052 · Cited by 132
Wood, L. G., Simpson, J. L., Hansbro, P. M., & Gibson, P. G. (2009) · Free Radical Research · doi:10.3109/10715760903362576 · Cited by 122
Dysregulation of T-Cell Function in the Elderly
Fülöp, T., Larbi, A., Wikby, A., Mocchegiani, E., Hirokawa, K., & Pawelec, G. (2005) · Drugs & Aging · doi:10.2165/00002512-200522070-00005 · Cited by 122
B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans
Bulati, M., Buffa, S., Candore, G., Caruso, C., Dunn‐Walters, D. K., Pellicanò, M., Wu, Y.-C. B., & Romano, G. C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.12.002 · Cited by 121
Aging impairs mitochondrial respiratory capacity in classical monocytes
Pence, B. D., & Yarbro, J. R. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.04.008 · Cited by 120
Salminen, A., Ojala, J. O., Huuskonen, J., Kauppinen, A., Suuronen, T., & Kaarniranta, K. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7461-3 · Cited by 120
Vescovini, R., Telera, A. R., Fagnoni, F. F., Biasini, C., Medici, M. C., Valcavi, P., Pede, P. D., Lucchini, G., Zanlari, L., Passeri, G., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.004 · Cited by 120
Self-citationInflammation and reactivation of latent herpesviruses in older adults
Bennett, J. M., Glaser, R., Malarkey, W. B., Beversdorf, D. Q., Peng, J., & Kiecolt-Glaser, J. K. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.007 · Cited by 118
Immunosenescence in vertebrates and invertebrates
Müller, L., Fülöp, T., & Pawelec, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-12 · Cited by 117
Meyer, K. C. (2003) · Ageing Research Reviews · doi:10.1016/j.arr.2003.07.002 · Cited by 114
Ouyang, Q., Wagner, W. M., Walter, S., Müller, C. A., Wikby, A., Aubert, G., Klatt, T., Stevanović, S., Dodi, T., & Pawelec, G. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00026-5 · Cited by 113
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112
Theories of Aging: An Ever-Evolving Field
Владимирович, С. П., Dontsova, O. А., & Berezkin, G. V. (2015) · Acta Naturae · doi:10.32607/20758251-2015-7-1-9-18 · Cited by 116
Aging and Injury: Alterations in Cellular Energetics and Organ Function
Poulose, N. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500101 · Cited by 109
Reversing age-associated immunosenescence via exercise
Kohut, M. L., & Senchina, D. S. (2026) · PubMed · doi:10.22029/eir.2004.1603 · Cited by 109
Cancer cell-intrinsic mechanisms driving acquired immune tolerance
Ghorani, E., Swanton, C., & Quezada, S. A. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.004 · Cited by 116
Mitigating Cellular Inflammation in Older Adults: A Randomized Controlled Trial of Tai Chi Chih
Irwin, M. R., & Olmstead, R. E. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182330fd3 · Cited by 107
Role of persistent CMV infection in configuring T cell immunity in the elderly
Vasto, S., Colonna‐Romano, G., Larbi, A., Wikby, A., Caruso, C., & Pawelec, G. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-2 · Cited by 101
Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., van Heemst, D., Suchiman, H. E. D., et al. (2017) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glw185 · Cited by 100
Self-citationKverneland, A. H., Streitz, M., Geissler, E., Hutchinson, J., Vogt, K., Boës, D., Niemann, N., Pedersen, A. E., Schlickeiser, S., & Sawitzki, B. (2016) · Cytometry Part A · doi:10.1002/cyto.a.22855 · Cited by 99
Linton, P. (2001) · Frontiers in bioscience · doi:10.2741/linton · Cited by 97
Immunosenescence in some but not all immune components in a free-living vertebrate, the tree swallow
Palacios, M. G., Cunnick, J. E., Winkler, D. W., & Vleck, C. M. (2007) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2006.0192 · Cited by 95
Wu, K., Higashi, N., Hansen, E. R., Lund, M., Bang, K., & Thestrup‐Pedersen, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4742 · Cited by 95
Metadata
- Authors
- Franceschi, C., Bonafè, M., & Valensin, S.
- Affiliations
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- University of Bologna (IT)
- Corresponding author
- Franceschi, Claudio
- ORCID
- Bonafè, Massimiliano
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 18
- Issue
- 16
- Pages
- 1717-1720
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W1981560461
- Cited by
- 495
- References
- 20
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 10 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 16 · 2017: 38 · 2016: 23 · 2015: 26 · 2014: 24 · 2013: 32 · 2012: 21
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- immunosenescence, innate immunity, T cell receptor repertoire, naive T cells, CD8+CD28- T cells, NK cell cytotoxicity, evolutionary immunology, thymic involution, immunological memory, aging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Antigens, Cell Division, Biological Evolution, Humans, Immunity, Innate, Immunologic Memory, Lymphocyte Activation, Models, Biological, Stress, Physiological, T-Lymphocytes, Telomere
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
