Coenzymes as coribozymes
Abstract
Coenzymes are small organic molecules that supply a varied set of reactive groups to protein enzymes, thereby diversifying catalysis beyond the chemistries of amino acid sidechains. As RNA structures begin with a more limited chemical diversity than proteins, it seems likely that RNA enzymes would also use functional groups from other molecules to support a complex RNA world metabolism. In fact, ribonucleotide moieties in many coenzymes have long been thought to be surviving vestiges of covalently bound coenzymes in an RNA world. The idea of coenzyme utilization by ribozymes can be explored by selection-amplification of coenzyme-binding RNAs and coenzyme-assisted ribozymes. Here, we review coenzyme-RNAs, and discuss their possible significance for RNA-mediated metabolism. In summary, a plausible route from prebiotic chemistry to ribozyme biochemistry exists for CoA, and via similar activities, likely exists for all the nucleotidyl coenzymes.
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Present-day low molecular weight cofactors may have been early non-protein catalysts.
“This notion obtains further support from the experiment-based proposals that present-day low molecular weight cofactors may have been early non-protein catalysts [32,204,205,213,214].”
From Systems protobiology: origin of life in lipid catalytic networks (2018) · cites this paper as [204]
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Coenzymes, viruses and the RNA world
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- Authors
- Jadhav, V. R., & Yarus, M.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Yarus, Michael
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 84
- Issue
- 9
- Pages
- 877-888
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- OpenAlex
- W1995639982
- Cited by
- 73
- References
- 70
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimie (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM-30881)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- coenzymes, ribozymes, RNA world, coenzyme A, prebiotic chemistry
- MeSH terms
- Origin of Life, Base Sequence, Catalysis, Coenzymes, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Catalytic, Evolution, Molecular
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