Evolution of the genetic apparatus

Orgel, L.E.

doi:10.1016/0022-2836(68)90393-8

Cited by 996Origins and Evolution of LifeRNA and protein synthesis mechanismsEvolution and Genetic Dynamics

Evolution of the genetic apparatus

Orgel, L.E.·1968·Journal of Molecular Biology

DOI 10.1016/0022-2836(68)90393-8

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All living systems follow a principle of continuity in which new structures and systems emerge through variations on similar earlier forms.
“Orgel (1968) and Morowitz (1992) proposed that all living systems follow a principle of continuity in which new structures and systems emerge through variations on similar earlier forms.”
From The Hot Spring Hypothesis for an Origin of Life (2020) · cites this paper as Orgel (1968)
The RNA world theory posits that RNA fulfilled both catalysis and information storage during an early stage of life.
“The RNA world theory posits that RNA fulfilled both of the major cellular functions, catalysis and information storage, during an early stage of life (1–3).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [3]
The biology of modern organisms is based on RNA, DNA and proteins, but this biochemistry was probably preceded by a stage in which RNA molecules acted both as chemical catalysts and carriers of genetic information.
“The biology of modern organisms is based on RNA, DNA and proteins, but this biochemistry was probably preceded by a stage in which RNA molecules acted both as chemical catalysts and carriers of genetic information.”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [2]

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Authors: Orgel, L. E.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Orgel, L.E.
Venue: Journal of Molecular Biology
Publisher: Elsevier BV
Published: 1968-12
Volume: 38
Issue: 3
Pages: 381-393
ISSN: 0022-2836 (ISSN-L)
DOI: 10.1016/0022-2836(68)90393-8
OpenAlex: W2003825614
Cited by: 996
References: 13
Citations by year: 2026: 23 · 2025: 28 · 2024: 35 · 2023: 33 · 2022: 30 · 2021: 39 · 2020: 28 · 2019: 46 · 2018: 30 · 2017: 32 · 2016: 35 · 2015: 41 · 2014: 31 · 2013: 21 · 2012: 42
FWCI: 10.05
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: polynucleotides, origin of life, genetic code evolution
MeSH terms: Amino Acids, Astronomy, Biological Evolution, Genetic Code, Geology, Nucleic Acids, Nucleotides, Paleontology, RNA, Transfer, Macromolecular Substances, Astronomical Phenomena, Geological Phenomena

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