Pregnancy after intravenous pulsatile gonadotropin-releasing hormone in a hyperprolactinaemic woman resistant to treatment with dopamine agonists
Abstract
It is difficult to achieve pregnancy in hyperprolactinaemic patients in whom prolactin inhibiting agents are ineffective. Medical treatment with bromocriptine, lisuride and the new agent CV 205-502 (quinagolide) was unsuccessful in normalizing hyperprolactinaemia in a 28 year-old woman to treat anovulatory infertility. Repeated Magnetic Resonance Imaging (MRI) was normal, with no images suggestive of prolactin adenoma. A live child was born after pulsatile GnRH treatment despite persistently elevated prolactin levels; normal MRI and decreased prolactin levels were observed after pregnancy. In summary, successful pregnancy can be obtained with pulsatile GnRH treatment in women resistant to old and new medical treatments of hyperprolactinaemia.
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Pulsatile GnRH replacement can reverse the infertility induced by hyperprolactinemia.
“Pulsatile GnRH replacement can reverse the infertility induced by hyperprolactinemia (11, 12)”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [12]
The principal mechanism of hyperprolactinemia-associated infertility is prolactin-induced suppression of GnRH release.
“suggesting that the principal mechanism of hyperprolactinemia-associated infertility is prolactin (PRL)-induced suppression of GnRH release.”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [12]
Cites
Resistance to Bromocriptine in Prolactinomas
Pellegrini, I., Rasolonjanahary, R., Gunz, G., BERTRAND, P., Delivet, S., Jedynak, C. P., Kordon, C., Peillon, F., Jaquet, P., & Enjalbert, A. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-500 · Cited by 265 · see citing works
Outcome of Pregnancy in Women with Pituitary Adenoma
Wallach, E. E., GEMZELL, C. A., & Wang, C. F. (1979) · Fertility and Sterility · doi:10.1016/s0015-0282(16)43929-4 · Cited by 206 · see citing works
Prolactinomas resistant to bromocriptine: long-term efficacy of quinagolide and outcome of pregnancy
Morange, I., Barlier, A., Pellegrini, I., Brue, T. C., Enjalbert, A., & Jaquet, P. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1350413 · Cited by 104 · see citing works
Women with prolactinoma – effect of pregnancy and lactation on serum prolactin and on tumour growth
Holmgren, U., Bergstrand, G., Hagenfeldt, K., & Werner, S. (1986) · European Journal of Endocrinology · doi:10.1530/acta.0.1110452 · Cited by 88 · see citing works
Effects of the dopamine agonist CV 205-502 in human prolactinomas resistant to bromocriptine.
Brue, T. C., Pellegrini, I., Gunz, G., Morange, I., Dewailly, D., Brownell, J., Enjalbert, A., & Jaquet, P. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.3.1346788 · Cited by 68 · see citing works
Influence of pregnancies on prolactinomas
Rjosk, H. Κ., Fahlbusch, R., & von Werder, K. (1982) · European Journal of Endocrinology · doi:10.1530/acta.0.1000337 · Cited by 60 · see citing works
Duranteau, L., Chanson, P., Lavoinne, A., Horlait, S., Lubetzki, J., & Kuhn, J. M. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb01731.x · Cited by 58 · see citing works
POLSON, D. W., SAGLE, M., MASON, H. D., ADAMS, J., JACOBS, H. S., & FRANKS, S. (1986) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1986.tb03282.x · Cited by 40 · see citing works
CV 205‐502: A NEW LONG‐ACTING DRUG FOR INHIBITION OF PROLACTIN HYPERSECRETION
RASMUSSEN, C., Bergh, T., WIDE, L. E., & Brownell, J. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb00789.x · Cited by 39 · see citing works
Prolactin synthesis and release during pregnancy and puerperium
Kletzky, O. A., Marrs, R. P., Howard, W. F., McCormick, W., & Mishell, D. R. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90686-9 · Cited by 31 · see citing works
Effects of the dopamine agonist CV 205-502 in human prolactinomas resistant to bromocriptine
Brue, T. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.74.3.577 · Cited by 23 · see citing works
Padilla, S. L., Person, G. K., McDonough, P. G., & Reindollar, R. H. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48989-2 · Cited by 18 · see citing works
Mornex, R., & Hugues, B. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101033240116 · Cited by 9 · see citing works
Remission of Hyperprolactinemia after Pregnancy
(1991) · New England Journal of Medicine · doi:10.1056/nejm199101033240115 · Cited by 7 · see citing works
Hibbard, L. T. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90583-9 · Cited by 1 · see citing works
Prolactin resistance to bromocryptine treatment: a case report.
Borenstein, R., Kessler, I., & Ben-David, M. (1981) · PubMed · Cited by 1 · see citing works
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60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis
Grattan, D. R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0213 · Cited by 357 · see citing works
Prolactin: A Pleiotropic Neuroendocrine Hormone
Grattan, D. R., & Kokay, I. C. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01736.x · Cited by 309 · see citing works
Prolactin — a pleiotropic factor in health and disease
Bernard, V., Young, J., & Binart, N. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0194-6 · Cited by 283 · see citing works
New insights in prolactin: pathological implications
Bernard, V., Young, J., Chanson, P., & Binart, N. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.36 · Cited by 244 · see citing works
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
Sonigo, C., Bouilly, J., Carré, N., Tolle, V., Caraty, A., Tello, J., Simony-Conesa, F.-J., Millar, R., Young, J., & Binart, N. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63937 · Cited by 197 · see citing works
Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007) · Endocrinology · doi:10.1210/en.2007-0403 · Cited by 145 · see citing works
Kokay, I. C., Petersen, S. L., & Grattan, D. R. (2011) · Endocrinology · doi:10.1210/en.2010-0668 · Cited by 131 · see citing works
Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12223 · Cited by 97 · see citing works
Physiology of Gnrh and Gonadotropin Secretion
Marques, P., Skorupskaite, K., George, J. T., & Anderson, R. A. (2015) · Cited by 95 · see citing works
Kisspeptin Cells in the Ovine Arcuate Nucleus Express Prolactin Receptor but not Melatonin Receptor
Li, Q., Rao, A., Pereira, A. Z., Clarke, I. J., & Smith, J. T. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02195.x · Cited by 69 · see citing works
Millar, R. P., Sonigo, C., Anderson, R. A., George, J. T., Maione, L., Brailly‐Tabard, S., Chanson, P., Binart, N., & Young, J. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00328 · Cited by 68 · see citing works
Brown, R. S. E., Khant Aung, Z., Phillipps, H. R., Barad, Z., Lein, H.-J., Boehm, U., Szawka, R. E., & Grattan, D. R. (2019) · Endocrinology · doi:10.1210/en.2019-00038 · Cited by 62 · see citing works
Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature
Iancu, M., Albu, A. I., & Albu, D. N. (2023) · Pharmaceuticals · doi:10.3390/ph16010122 · Cited by 41 · see citing works
Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans
Hoskova, K., Kayton Bryant, N., Chen, M. E., Nachtigall, L. B., Lippincott, M. F., Balasubramanian, R., & Seminara, S. B. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac166 · Cited by 39 · see citing works
Chen, H., Fu, J., & Huang, W. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008883.pub2 · Cited by 34 · see citing works
Prolactin: structure, receptors, and functions
Chasseloup, F., Bernard, V., & Chanson, P. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09915-8 · Cited by 34 · see citing works
Hypothalamic Control of Prolactin Secretion, and the Multiple Reproductive Functions of Prolactin
Grattan, D. R., & Tissier, P. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00012-0 · Cited by 31 · see citing works
Interpretation of Serum Gonadotropin Levels in Hyperprolactinaemia
Abbara, A., Clarke, S. A., Nesbitt, A., Ali, S., Comninos, A. N., Hatfield, E. C. I., Martin, N. M., Sam, A. H., Meeran, K. M., & Dhillo, W. S. (2018) · Neuroendocrinology · doi:10.1159/000489264 · Cited by 22 · see citing works
Silva, J. F., Henriques, P. C., Campideli-Santana, A. C., Araújo-Lopes, R., Aquino, N. S. S., Hipolito, L. T. M., Lopes‐Aguiar, C., dos Reis, A. M., Grattan, D. R., & Szawka, R. E. (2020) · Endocrinology · doi:10.1210/endocr/bqaa022 · Cited by 22 · see citing works
The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction
Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107911 · Cited by 20 · see citing works
Grattan, D. R., & Szawka, R. E. (2019) · Seminars in Reproductive Medicine · doi:10.1055/s-0039-3400956 · Cited by 17 · see citing works
Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters
Spaggiari, G., Costantino, F., Granata, A. R. M., Tagliavini, S., Canu, G., Varani, M., Santis, M. C. D., Roli, L., Trenti, T., Simoni, M., et al. (2023) · Endocrine · doi:10.1007/s12020-023-03375-x · Cited by 13 · see citing works
Prolactin Actions in the Brain
Grattan, D. R., & Bridges, R. S. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00079-6 · Cited by 8 · see citing works
Chen, H., & Hu, L. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008883 · Cited by 9 · see citing works
La prolactine et son récepteur : Des modèles animaux à la physiopathologie hypophysaire
Begon, E., & Bernard, V. (2022) · Biologie Aujourd hui · doi:10.1051/jbio/2022019 · Cited by 6 · see citing works
Mattle, & Wildt, L. (2012) · Journal für Reproduktionsmedizin und Endokrinologie · Cited by 6 · see citing works
Weiss, R. B., Schook, M. W., & Wolfe, B. A. (2014) · Zoo Biology · doi:10.1002/zoo.21125 · Cited by 4 · see citing works
Neue Aspekte in der Diagnostik und Therapie der Hyperprolaktinämie
Grubinger, E., Wildt, L., & Mattle (2009) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 2 · see citing works
Effects of Ovariectomy and Sex Steroids on Prolactin Synthesis
Cairang, Z., Kanasaki, H., Tumurbaatar, T., Yacca, S. S., Oride, A., Okada, H., & Kyo, S. (2025) · International Journal of Endocrinology · doi:10.1155/ije/8883536 · Cited by 1 · see citing works
Incidence of Hyperprolactinemia in Infertile Women
Kalaivani, & vidhyalakshmi, D. (2014) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-131170710 · Cited by 1 · see citing works
Kisspeptin: From Bench to Bedside
Mills, E., Patel, B., & Dhillo, W. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00021-9 · Cited by 1 · see citing works
Troubles de la fertilité d'origine endocrinienne
Lecomte, P., & Gervaise, N. (2004) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(04)74274-2 · Cited by 1 · see citing works
Self-citationLecomte, P., & Lecomte, C. (2000) · EMC - Ginecología-Obstetricia · doi:10.1016/s1283-081x(00)71877-7
Self-citationLecomte, P., & Lecomte, C. (2006) · EMC - Gynécologie · doi:10.1016/s0246-1064(00)00030-x
Self-citationQuarde, A. (2023) · Wiley eBooks · doi:10.1002/9781119863564.ch6
- Authors
- Lecomte, P., Lecomte, C., Lansac, J., Gallier, J., Sonier, C. B., & Simonetta, C.
- Affiliations
- Centre Hospitalier Universitaire de Tours (FR)
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 74
- Issue
- 2
- Pages
- 219-221
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2037372570
- Cited by
- 35
- References
- 16
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2012: 2
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- hyperprolactinemia, pulsatile GnRH therapy, pregnancy, dopamine agonist resistance, bromocriptine, quinagolide, anovulatory infertility, prolactin, prolactinoma
- MeSH terms
- Adult, Female, Humans, Hyperprolactinemia, Infertility, Female, Infusion Pumps, Gonadotropin-Releasing Hormone, Male, Pregnancy, Pregnancy Outcome, Pulsatile Flow
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