Cited by 35Pituitary Gland Disorders and TreatmentsHypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth Factors

Pregnancy after intravenous pulsatile gonadotropin-releasing hormone in a hyperprolactinaemic woman resistant to treatment with dopamine agonists

Lecomte, P., Lecomte, C., Lansac, J., Gallier, J., Sonier, C.B., Simonetta, C.·1997·European Journal of Obstetrics & Gynecology and Reproductive Biology

Abstract

It is difficult to achieve pregnancy in hyperprolactinaemic patients in whom prolactin inhibiting agents are ineffective. Medical treatment with bromocriptine, lisuride and the new agent CV 205-502 (quinagolide) was unsuccessful in normalizing hyperprolactinaemia in a 28 year-old woman to treat anovulatory infertility. Repeated Magnetic Resonance Imaging (MRI) was normal, with no images suggestive of prolactin adenoma. A live child was born after pulsatile GnRH treatment despite persistently elevated prolactin levels; normal MRI and decreased prolactin levels were observed after pregnancy. In summary, successful pregnancy can be obtained with pulsatile GnRH treatment in women resistant to old and new medical treatments of hyperprolactinaemia.

Integrity signals

Registry

Crossref · 10.1016/s0301-2115(97)00091-2

Cites

16 of 16 references verified0 citation errors · 0 not checkable

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Authors
Lecomte, P., Lecomte, C., Lansac, J., Gallier, J., Sonier, C. B., & Simonetta, C.
Affiliations
Centre Hospitalier Universitaire de Tours (FR)
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
1997-08
Volume
74
Issue
2
Pages
219-221
ISSN
  • 0028-2243 (ISSN-L)
  • 0301-2115
OpenAlex
W2037372570
Cited by
35
References
16
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2012: 2
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
hyperprolactinemia, pulsatile GnRH therapy, pregnancy, dopamine agonist resistance, bromocriptine, quinagolide, anovulatory infertility, prolactin, prolactinoma
MeSH terms
Adult, Female, Humans, Hyperprolactinemia, Infertility, Female, Infusion Pumps, Gonadotropin-Releasing Hormone, Male, Pregnancy, Pregnancy Outcome, Pulsatile Flow

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