Ovulation and normal luteal function during LHRH treatment of women with hyperprolactinaemic amenorrhoea
Abstract
Five patients with hyperprolactinaemic amenorrhoea who had been resistant to, or intolerant of bromocriptine were treated with pulsatile LHRH therapy. Ovulation was induced in 9 of 12 treatment cycles. In one patient hyperstimulation occurred in the first cycle of treatment but subsequently she ovulated normally on a reduced dose of LHRH. The gonadotrophin and ovarian responses to treatment in ovulatory cycles were normal despite prolactin concentrations that remained elevated throughout treatment and rose still further with resumption of ovarian activity. The length of the luteal phase and the mid-luteal serum progesterone concentrations were also normal. Pulsatile secretion of progesterone in response to LHRH pulses were observed. These data show that ovulation and normal luteal function can be induced by physiological LHRH replacement in women with persistent hyperprolactinaemia. This confirms that the mechanism of anovulation in hyperprolactinaemic amenorrhoea is disordered LHRH secretion.
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Pulsatile GnRH replacement can reverse the infertility induced by hyperprolactinemia.
“Pulsatile GnRH replacement can reverse the infertility induced by hyperprolactinemia (11, 12)”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [11]
The principal mechanism of hyperprolactinemia-associated infertility is prolactin-induced suppression of GnRH release.
“suggesting that the principal mechanism of hyperprolactinemia-associated infertility is prolactin (PRL)-induced suppression of GnRH release.”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [11]
Cites
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Self-citationHyperprolactinemic Anovulatory Syndrome*
Bohnet, H. G., Dahlén, H. G., Wuttke, W., & Schneider, H. P. G. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-1-132 · Cited by 264 · see citing works
An abnormality of oestrogen feedback in amenorrhoea-galactorrhoea.
Glass, M. R., Shaw, R. W., BUTT, W. R., EDWARDS, R. L., & London, D. R. (1975) · BMJ · doi:10.1136/bmj.3.5978.274 · Cited by 156 · see citing works
CLINICAL AND ENDOCRINE FEATURES OF HYPERPROLACTINAEMIC AMENORRHOEA
Jacobs, H. S., Franks, S., Murray, M. A. F., Hull, M. G. R., Steele, S. J., & Nabarro, J. D. N. (1976) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1976.tb01974.x · Cited by 132 · see citing works
Self-citationMOULT, P. J. A., REES, L. H., & BESSER, G. M. (1982) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1982.tb03159.x · Cited by 104 · see citing works
Regulation of Prolactin Secretion by Oestrogens: Physiological and Pathological Significance
Franks, S. (1983) · Clinical Science · doi:10.1042/cs0650457 · Cited by 65 · see citing works
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Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007) · Endocrinology · doi:10.1210/en.2007-0403 · Cited by 145 · see citing works
Kokay, I. C., Petersen, S. L., & Grattan, D. R. (2011) · Endocrinology · doi:10.1210/en.2010-0668 · Cited by 131 · see citing works
Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans
Hoskova, K., Kayton Bryant, N., Chen, M. E., Nachtigall, L. B., Lippincott, M. F., Balasubramanian, R., & Seminara, S. B. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac166 · Cited by 39 · see citing works
Lecomte, P., Lecomte, C., Lansac, J., Gallier, J., Sonier, C. B., & Simonetta, C. (1997) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(97)00091-2 · Cited by 35 · see citing works
- Authors
- POLSON, D. W., SAGLE, M., MASON, H. D., ADAMS, J., JACOBS, H. S., & FRANKS, S.
- Affiliations
- St Mary's Hospital (GB)
- Corresponding author
- FRANKS, S.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1986-05
- Volume
- 24
- Issue
- 5
- Pages
- 531-537
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2091079884
- Cited by
- 40
- References
- 6
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2015: 2 · 2014: 3
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- ovulation induction, luteal phase, luteal function, progesterone secretion, prolactin, anovulation, gonadotrophin response
- MeSH terms
- Adult, Amenorrhea, Corpus Luteum, Female, Humans, Gonadotropin-Releasing Hormone, Ovulation, Progesterone, Prolactin
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