Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta
Abstract
One of the most important local adaptations to pregnancy is the change in maternal blood flow to the implantation site. In rodents and primates, new blood vessels form through angiogenesis, dilate and then become modified such that the blood enters into trophoblast cell-lined sinuses (hemochorial). Evidence from gene knockout mice suggests that factors from the placenta regulate the uterine vasculature. Consistent with this, trophoblast giant cells produce a number of angiogenic and vasoactive substances that may mediate these effects. Teratocarcinomas containing large numbers of trophoblast giant cells (derived from Parp1 gene-deficient ES cells) show similar 'hemochorial' host blood flow, implying that the effects are not specific to the uterine vascular bed. As in primates, murine trophoblast cells also invade into the uterine arteries of the mother. However, in normal pregnancy, dilation of the uterine arteries may be largely mediated by the effect of uterine natural killer cells.
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Endothelial cell dysfunction has been associated with placental pathology and disease states.
“Since endothelial cell dysfunction has been associated with placental pathology and disease states29–32,”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [32]
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Interactions between Trophoblast Cells and the Maternal and Fetal Circulation in the Mouse Placenta
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- Authors
- Cross, J. C., Hemberger, M., Lu, Y., Nozaki, T., Whiteley, K., Masutani, M., & Adamson, S. L.
- Affiliations
- University of Calgary (CA)
- Mount Sinai Hospital (CA)
- National Cancer Center Research Institute (JP)
- Corresponding author
- Cross, J.C
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 187
- Issue
- 1-2
- Pages
- 207-212
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W1995211798
- Cited by
- 293
- References
- 25
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 16 · 2020: 11 · 2019: 11 · 2018: 12 · 2017: 13 · 2016: 13 · 2015: 12 · 2014: 8 · 2013: 12 · 2012: 20
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Gestational Trophoblastic Disease Studies
- Keywords
- trophoblast, angiogenesis, placenta, hemochorial placenta, trophoblast giant cells, uterine blood flow, uterine artery, uterine natural killer cells, teratocarcinoma, PARP1, knockout mice, uterine vasculature
- MeSH terms
- Animals, Female, Humans, Placenta, Pregnancy, Trophoblasts, Uterus, Neovascularization, Physiologic, Placental Circulation, Angiogenesis Inducing Agents
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