Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,612 · see citing works

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,837 · see citing works

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,437 · see citing works

Placental development: Lessons from mouse mutants

Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,273 · see citing works

Akt regulates growth by directly phosphorylating Tsc2

Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959 · see citing works

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., & Birnbaum, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100462200 · Cited by 959 · see citing works

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 genePreprint

Chen, W. S., Xu, P.-Z., Gottlob, K., Chen, M.-L., Sokol, K. A., Shiyanova, T., Roninson, I. B., Weng, W., Suzuki, R., Tobe, K., et al. (2001) · Genes & Development · doi:10.1101/gad.913901 · Cited by 926 · see citing works

Size Control in Animal Development

Conlon, I. J., & RAFF, M. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80563-2 · Cited by 743 · see citing works

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B., & Pan, D. (2002) · Nature Cell Biology · doi:10.1038/ncb847 · Cited by 719 · see citing works

Interactions between Trophoblast Cells and the Maternal and Fetal Circulation in the Mouse Placenta

Adamson, S. L., Lu, Y., Whiteley, K. J., Holmyard, D., Hemberger, M., Pfarrer, C., & Cross, J. C. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0773 · Cited by 617 · see citing works

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

Hafezi‐Moghadam, A., Simoncini, T., Yang, Z., Limbourg, F. P., Plumier, J.-C., Rebsamen, M. C., Hsieh, C.-M., Chui, D.-S., Thomas, K. L., Prorock, A. J., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-473 · Cited by 595 · see citing works

Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice

Shioi, T., McMullen, J., Kang, P., Douglas, P., Obata, T., Franke, T. F., Cantley, L., & Izumo, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2799-2809.2002 · Cited by 544 · see citing works

Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase

Duplain, H., Burcelin, R., Sartori, C., Cook, S., Egli, M., Lepori, M., Vollenweider, P., Pedrazzini, T., Nicod, P., Thorens, B., et al. (2001) · Circulation · doi:10.1161/01.cir.104.3.342 · Cited by 533 · see citing works

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., & Hemmings, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4171 · Cited by 532 · see citing works

Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

Tuttle, R. L., Gill, N. S., Pugh, W., Lee, J.-P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., & Birnbaum, M. J. (2001) · Nature Medicine · doi:10.1038/nm1001-1133 · Cited by 511 · see citing works

The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth.

Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E., & Waterfield, M. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01049.x · Cited by 487 · see citing works

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Williams, M. R., Arthur, J. S. C., Balendran, A., KAAY, J. V. D., Poli, V., Cohen, P., & Alessi, D. R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00441-3 · Cited by 471 · see citing works

Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart

Matsui, T., Li, L., Wu, J. C., Cook, S. A., Nagoshi, T., Picard, M. H., Liao, R., & Rosenzweig, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200347200 · Cited by 434 · see citing works

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

Verdú, J., Buratovich, M., Wilder, E., & Birnbaum, M. (1999) · Nature Cell Biology · doi:10.1038/70293 · Cited by 397 · see citing works

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

Bernal‐Mizrachi, E., Wu, W., Stahlhut, S., Welling, C. M., & Permutt, M. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13785 · Cited by 382 · see citing works

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

Leitges, M., Sanz, L., Martı́n, P., Durán, Á., Braun, U., García, J. F., Camacho, F., Díaz-Meco, M. T., Rennert, P. D., & Moscat, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00361-6 · Cited by 371 · see citing works

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

Oršulić, S., Li, Y., Soslow, R. A., Vitale-Cross, L. A., Gutkind, J. S., & VARMUS, H. E. (2002) · Cancer Cell · doi:10.1016/s1535-6108(01)00002-2 · Cited by 358 · see citing works

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

Bernal‐Mizrachi, E., Wu, W., Stahlhut, S., Welling, C. M., & Permutt, M. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113785 · Cited by 332 · see citing works

Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta

Cross, J. C., Hemberger, M., Lu, Y., Nozaki, T., Whiteley, K., Masutani, M., & Adamson, S. L. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00703-1 · Cited by 293 · see citing works

Placental-fetal Interrelationship in IUGR Fetuses—A Review

Pardi, G., Marconi, A. M., & Cetin, I. (2002) · Placenta · doi:10.1053/plac.2002.0802 · Cited by 287 · see citing works

Placental Development in Normal and Compromised Pregnancies— A Review

Regnault, T. R. H., Galan, H. L., Parker, T. A., & Anthony, R. V. (2002) · Placenta · doi:10.1053/plac.2002.0792 · Cited by 264 · see citing works

Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

Luo, Z., Fujio, Y., Kureishi, Y., Rudic, R. D., Daumerie, G., Fulton, D. J., Sessa, W. C., & Walsh, K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9419 · Cited by 212 · see citing works

Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB

Stocker, H., Andjelković, M., Oldham, S., Laffargue, M., Wymann, M. P., Hemmings, B. A., & Hafen, E. (2002) · Science · doi:10.1126/science.1068094 · Cited by 198 · see citing works

Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Limbourg, F. P., Huang, Z., Plumier, J.-C., Simoncini, T., Fujioka, M., Tuckermann, J. P., Schütz, G., Moskowitz, M. A., & Liao, J. K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15481 · Cited by 187 · see citing works

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

Bellacosa, A., Franke, T. F., González, M. E., Datta, K., Taguchi, T., Gardner, J., Cheng, J. Q., Testa, J. R., & Tsichlis, P. N. (1993) · PubMed · Cited by 176 · see citing works

Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Limbourg, F. P., Huang, Z., Plumier, J.-C., Simoncini, T., Fujioka, M., Tuckermann, J. P., Schütz, G., Moskowitz, M. A., & Liao, J. K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215481 · Cited by 176 · see citing works

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

Altomare, D. A., Lyons, G. E., Mitsuuchi, Y., Cheng, J. Q., & Testa, J. R. (1998) · Oncogene · doi:10.1038/sj.onc.1201750 · Cited by 138 · see citing works

Insulin-like growth factor II affects the appearance and glycogen content of glycogen cells in the murine placenta

Lopez, M. F., Dikkes, P., Zurakowski, D., & Villa‐Komaroff, L. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612553 · Cited by 115 · see citing works

Functional Reconstitution of Endothelial Nitric Oxide Synthase Reveals the Importance of Serine 1179 in Endothelium-Dependent Vasomotion

Scotland, R. S., Morales‐Ruiz, M., Chen, Y., Yu, J., Rudic, R. D., Fulton, D. J., Gratton, J., & Sessa, W. C. (2002) · Circulation Research · doi:10.1161/01.res.0000016506.04193.96 · Cited by 110 · see citing works

Perinatal Development of Endothelial Nitric Oxide Synthase-Deficient Mice1

Hefler, L., Reyes, C., O’Brien, W. E., & Gregg, A. R. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.2.666 · Cited by 100 · see citing works

Mouse ES cells: experimental exploitation of pluripotent differentiation potential

Rathjen, J., & Rathjen, P. D. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00237-9 · Cited by 96 · see citing works

Platelet activation leads to increased c-src kinase activity and association of c-src with an 85-kDa tyrosine phosphoprotein.

Wong, S. T. C., Ab, R., & Papkoff, J. (1992) · PubMed · Cited by 77 · see citing works

The Challenges of Translating Knockout Phenotypes into Gene Function

Ihle, J. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00017-9 · Cited by 73 · see citing works

The IGF system during fetal-placental development of the mouse

Kleffens, M. D.-V., Groffen, C., Lindenbergh-Kortleve, D. J., van Neck, J. W., González‐Parra, S., Dits, N. F. J., Zwarthoff, E. C., & Drop, S. L. S. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00041-0 · Cited by 60 · see citing works

The Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Modulates the Endocrine Differentiation of Trophoblast Cells

Kamei, T., Jones, S. R., Chapman, B. M., McGonigle, K. L., Dai, G., & Soares, M. J. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.7.0878 · Cited by 54 · see citing works

Biological effects of growth hormone and its antagonist

Okada, S., & Kopchick, J. J. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)01933-5 · Cited by 51 · see citing works

Control of growth and development of the feto-placental unit.

Han, V., & Carter, A. (2001) · Current opinion in pharmacology (Print) · doi:10.1016/s1471-4892(01)00108-4 · Cited by 51 · see citing works

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833 · see citing works

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y., & Mills, G. B. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1902 · Cited by 2,183 · see citing works

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

Wee, P., & Wang, Z. (2017) · Cancers · doi:10.3390/cancers9050052 · Cited by 2,027 · see citing works

Akt signalling in health and disease

Hers, I., Vincent, E. E., & Tavaré, J. M. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.004 · Cited by 1,246 · see citing works

Advances in protein kinase B signalling: AKTion on multiple fronts

Brazil, D. P., Yang, Z., & Hemmings, B. A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.006 · Cited by 830 · see citing works

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816 · see citing works

The two TORCs and Akt

Bhaskar, P. T., & Hay, N. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.020 · Cited by 798 · see citing works

Structure, regulation and function of PKB/AKT—a major therapeutic target

Hanada, M., Feng, J., & Hemmings, B. A. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.11.009 · Cited by 719 · see citing works

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

Arranz, A., Doxaki, C., Vergadi, E., de la Torre, Y. M., Vaporidi, K., Lagoudaki, E. D., Ieronymaki, E., Androulidaki, A., Venihaki, M., Margioris, A. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119038109 · Cited by 605 · see citing works

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

Irie, H. Y., Pearline, R. V., Grueneberg, D. A., Hsia, M., Ravichandran, P., Kothari, N. H., Natesan, S., & Brugge, J. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505087 · Cited by 588 · see citing works

Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

(2009) · Advances in Cancer Research · doi:10.1016/s0065-230x(09)02002-8 · Cited by 486 · see citing works

Development of Structures and Transport Functions in the Mouse Placenta

Watson, E. D., & Cross, J. C. (2005) · Physiology · doi:10.1152/physiol.00001.2005 · Cited by 583 · see citing works

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

Easton, R., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M. ‐., Szabolcs, M. J., de Jong, R., Oltersdorf, T., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1869-1878.2005 · Cited by 551 · see citing works

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

Schultze, S. M., Hemmings, B. A., Nießen, M., & Tschopp, O. (2012) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002109 · Cited by 538 · see citing works

Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia

Burton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502 · see citing works

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

Tschopp, O., Yang, Z.-Z., Brodbeck, D., Dummler, B. A., Hemmings-Mieszczak, M., Watanabe, T., Michaelis, T., Frahm, J., & Hemmings, B. A. (2005) · Development · doi:10.1242/dev.01864 · Cited by 414 · see citing works

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388 · see citing works

Akt1/protein kinase B is critical for ischemic and VEGF-mediated angiogenesis

Ackah, E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24726 · Cited by 386 · see citing works

Determinants of trophoblast lineage and cell subtype specification in the mouse placenta

Simmons, D. G., & Cross, J. C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.010 · Cited by 357 · see citing works

Protein kinase B/Akt at a glance

Fayard, E., Tintignac, L. A. J., Baudry, A., & Hemmings, B. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02724 · Cited by 336 · see citing works

Critical growth factors and signalling pathways controlling human trophoblast invasion

Knfler, M. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082769mk · Cited by 330 · see citing works

The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility

Cattelino, A., Liebner, S., Gallini, R., Zanetti, A., Balconi, G., Corsi, A., Bianco, P., Wolburg, H., Moore, R. H., Boussadia, O., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212157 · Cited by 323 · see citing works

Physiological roles of PKB/Akt isoforms in development and disease

Dummler, B., & Hemmings, B. A. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350231 · Cited by 316 · see citing works

The influence of the intrauterine environment on human placental development

Burton, G. J., Jauniaux, E., & Charnock-Jones, D. S. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082764gb · Cited by 307 · see citing works

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404936200 · Cited by 294 · see citing works

Akt1 in Endothelial Cell and Angiogenesis

Somanath, P. R., Razorenova, O. V., Chen, J., & Byzova, T. V. (2006) · Cell Cycle · doi:10.4161/cc.5.5.2538 · Cited by 298 · see citing works

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

Dummler, B. A., Tschopp, O., Hynx, D., Yang, Z., Dirnhofer, S., & Hemmings, B. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00722-06 · Cited by 283 · see citing works

The PKB/AKT Pathway in Cancer

Carnero, A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161210789941865 · Cited by 271 · see citing works

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt

Matsui, T., & Rosenzweig, A. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.005 · Cited by 263 · see citing works

Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling

Kawamura, N., Kugimiya, F., Oshima, Y., Ohba, S., Ikeda, T., Saito, T., Shinoda, Y., Kawasaki, Y., Ogata, N., Hoshi, K., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001058 · Cited by 257 · see citing works

Protein Kinase B (PKB/Akt), a Key Mediator of the PI3K Signaling Pathway

Fayard, E., Xue, G., Parcellier, A., Bozulic, L., & Hemmings, B. A. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_58 · Cited by 247 · see citing works

Regulation of Placental Angiogenesis

Chen, D., & Zheng, J. J. (2013) · Microcirculation · doi:10.1111/micc.12093 · Cited by 243 · see citing works

Origin and characteristics of glycogen cells in the developing murine placenta

Coan, P. M., Conroy, N., Burton, G. J., & Ferguson‐Smith, A. C. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20981 · Cited by 243 · see citing works

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

Nagoshi, T., Matsui, T., Aoyama, T., Leri, A., Anversa, P., Li, L., Ogawa, W., del Monte, F., Gwathmey, J. K., Grazette, L. P., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23073 · Cited by 229 · see citing works

Imprinted genes in the placenta – A review

Coan, P. M., Burton, G. J., & Ferguson‐Smith, A. C. (2005) · Placenta · doi:10.1016/j.placenta.2004.12.009 · Cited by 231 · see citing works

Genetic insights into the mechanisms of Fgf signalingPreprint

Brewer, J. R., Mazot, P., & Soriano, P. M. (2016) · Genes & Development · doi:10.1101/gad.277137.115 · Cited by 224 · see citing works

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

Yang, Z., Tschopp, O., Di‐Poï, N., Bruder, E., Baudry, A., Dummler, B. A., Wahli, W., & Hemmings, B. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10407-10418.2005 · Cited by 220 · see citing works

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

Kaneshiro, S., Ebina, K., Shi, K., Higuchi, C., Hirao, M., OKAMOTO, M. T., Koizumi, K., Morimoto, T., Yoshikawa, H., & Hashi­moto, J. (2013) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-013-0514-1 · Cited by 218 · see citing works

Role of nitric oxide in placental vascular development and function

Krause, B. J., Hanson, M. A., & Casanello, P. C. (2011) · Placenta · doi:10.1016/j.placenta.2011.06.025 · Cited by 217 · see citing works

The Loss of Glypican-3 Induces Alterations in Wnt Signaling

Song, H. H., Shi, W., Xiang, Y., & Filmus, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410090200 · Cited by 214 · see citing works

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

Kitamura, T., Asai, N., Enomoto, A., Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1695 · Cited by 212 · see citing works

Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor β/δ

Nadra, K., Anghel, S. I., Joye, E., Tan, N. S., Modak, S. B., Trono, D., Wahli, W., & Desvergne, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3266-3281.2006 · Cited by 199 · see citing works

Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast Cells

Sk, G., Malhotra, S. S., Malik, A., Verma, S., & Chaudhary, P. (2015) · American Journal of Reproductive Immunology · doi:10.1111/aji.12436 · Cited by 196 · see citing works

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

Lorenzo, A. D., Fernandez-Hernando, C. F., Cirino, G., & Sessa, W. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904073106 · Cited by 190 · see citing works

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses

Matsuda, S., Ikeda, Y., Murakami, M., Nakagawa, Y., Tsuji, A., & Kitagishi, Y. (2019) · Diseases · doi:10.3390/diseases7010022 · Cited by 189 · see citing works

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta

Forbes, K. A., Westwood, M., Baker, P. N., & Aplin, J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00035.2008 · Cited by 187 · see citing works

Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

Sferruzzi-Perri, A. N., Sandovici, I., Constância, M., & Fowden, A. L. (2017) · The Journal of Physiology · doi:10.1113/jp273330 · Cited by 178 · see citing works

Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding

Héron‐Milhavet, L., Franckhauser, C., Rana, V., Berthenet, C., Fisher, D., Hemmings, B. A., Fernandez, A., & Lamb, N. J. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00201-06 · Cited by 178 · see citing works

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

Lee, M. Y., Luciano, A. K., Ackah, E., Rodríguez‐Vita, J., Bancroft, T. A., Eichmann, A., Simons, M., Kyriakides, T. R., Morales‐Ruiz, M., & Sessa, W. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408472111 · Cited by 174 · see citing works

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176 · see citing works

The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo

Riley, J. K., Carayannopoulos, M. O., Wyman, A., Chi, M. M.-Y., Ratajczak, C. K., & Moley, K. H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.033 · Cited by 173 · see citing works

Mapping of Deletion and Translocation Breakpoints in 1q44 Implicates the Serine/Threonine Kinase AKT3 in Postnatal Microcephaly and Agenesis of the Corpus Callosum

Boland, E., Clayton‐Smith, J., Woo, V. G. H., McKee, S. A., Manson, F. D. C., Medne, L., Zackai, E. H., Swanson, E. A., FitzPatrick, D. R., Millen, K. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519999 · Cited by 168 · see citing works

Regulation and Function of Protein Kinases and Phosphatases

Cheng, H.-C., Qi, R., Paudel, H., & Zhu, H.-J. (2011) · Enzyme Research · doi:10.4061/2011/794089 · Cited by 147 · see citing works

The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis

Jaiswal, N., Gavin, M. G., Quinn, W. J., Luongo, T. S., Gelfer, R. G., Baur, J. A., & Titchenell, P. M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.001 · Cited by 167 · see citing works

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

Agarwal, E., Brattain, M. G., & Chowdhury, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.025 · Cited by 164 · see citing works

The IGF Axis and Placental Function

Forbes, K. A., & Westwood, M. (2008) · Hormone Research in Paediatrics · doi:10.1159/000112585 · Cited by 164 · see citing works

Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early‐ and late‐onset pre‐eclampsia

Yung, H. W., Atkinson, D., Campion‐Smith, T., Olovsson, M., Charnock‐Jones, D. S., & Burton, G. J. (2014) · The Journal of Pathology · doi:10.1002/path.4394 · Cited by 156 · see citing works

Endothelial FAK is required for tumour angiogenesis

Tavora, B., Batista, S., Reynolds, L. E., Jadeja, S., Robinson, S. D., Kostourou, V., Hart, I. R., Fruttiger, M., Parsons, M., & Hodivala‐Dilke, K. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000106 · Cited by 151 · see citing works

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

Boehme, K. A., Kulikov, R., & Blattner, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703423105 · Cited by 151 · see citing works

Rapamycin Promotes Vascular Smooth Muscle Cell Differentiation through Insulin Receptor Substrate-1/Phosphatidylinositol 3-Kinase/Akt2 Feedback Signaling

Martin, K. A., Merenick, B. L., Ding, M., Fetalvero, K. M., Rzucidlo, E. M., Kozul, C. D., Brown, D. J., Chiu, H. Y., Shyu, M., Drapeau, B. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703914200 · Cited by 146 · see citing works

Calcineurin Signaling Regulates Human Islet β-Cell Survival*

Soleimanpour, S., Crutchlow, M. F., Ferrari, A. M., Raum, J. C., Groff, D., Rankin, M. M., Liu, C.-Y., León, D. D., Naji, A., Kushner, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.154955 · Cited by 124 · see citing works

Protein kinase B: signalling roles and therapeutic targeting

Sale, E. M., & Sale, G. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7274-9 · Cited by 144 · see citing works

Maternal growth factor regulation of human placental development and fetal growth

Forbes, K. A., & Westwood, M. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0174 · Cited by 144 · see citing works

The ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B

Schmidlin, M., Lu, M., Leuenberger, S. A., Stoecklin, G., Mallaun, M., Gross, B., Gherzi, R., Heß, D., Hemmings, B. A., & Moroni, C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600477 · Cited by 138 · see citing works

Gα i1 and Gα i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway

Cao, C., Huang, X., Han, Y., Wan, Y., Birnbaumer, L., Feng, G. S., Marshall, J. J., Jiang, M., & Chu, W. (2009) · Science Signaling · doi:10.1126/scisignal.2000118 · Cited by 137 · see citing works

Akt1 and Akt2 are required for αβ thymocyte survival and differentiation

Juntilla, M. M., Wofford, J. A., Birnbaum, M. J., Rathmell, J. C., & Koretzky, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705285104 · Cited by 136 · see citing works

Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia

Burton, G. J., & Yung, H. W. (2010) · Pregnancy Hypertension · doi:10.1016/j.preghy.2010.12.002 · Cited by 133 · see citing works

Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients

Huang, Z., Huang, S., Song, T., Yin, Y., & Tan, C. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab070 · Cited by 131 · see citing works

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., García‐Martínez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lang, F. J. W., Lipina, C., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02032-07 · Cited by 131 · see citing works

Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta

Kolahi, K. S., Valent, A. M., & Thornburg, K. L. R. (2017) · Scientific Reports · doi:10.1038/srep42941 · Cited by 125 · see citing works

Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway

Ain, R., Kent, L. N., & Soares, M. J. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06039 · Cited by 124 · see citing works

Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1

Tu, Q., Zhang, J., Dong, L., Saunders, E., Luo, E., Tang, J., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152405 · Cited by 123 · see citing works

Genetic inactivation of AKT1 , AKT2 , and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Ericson, K. M., Gan, C. M., Cheong, I., Rago, C., Samuels, Y., Velculescu, V. E., Kinzler, K. W., Huso, D. L., Vogelstein, B., & Papadopoulos, N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914018107 · Cited by 123 · see citing works

Akt Pathway Inhibitors

Uko, N. E., Güner, O. F., Matesic, D. F., & Bowen, J. P. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200224101808 · Cited by 123 · see citing works

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non‐native women at high altitude

Yung, H. W., Cox, M., van Patot, M. T., & Burton, G. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-190082 · Cited by 112 · see citing works

Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta

Withington, S. L., Scott, A., Saunders, D. N., Floro, K. L., Preis, J. I., Michalicek, J., Maclean, K., Sparrow, D. B., Martı́nez-Barberá, J. P., & Dunwoodie, S. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.025 · Cited by 112 · see citing works

Potential role of Akt signaling in chronic kidney disease

Lan, A., & Du, J. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu196 · Cited by 109 · see citing works

Suppression of survival signalling pathways by the phosphatase PHLPP

O’Neill, A., Niederst, M. J., & Newton, A. C. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08537.x · Cited by 107 · see citing works

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

Zhou, F., Chang, Z., Zhang, L., Hong, Y., Shen, B., Wang, B., Zhang, F., Lu, G., Tvorogov, D., Alitalo, K. K., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091301 · Cited by 104 · see citing works

Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells

Cassinelli, G., Zuco, V., Gatti, L., Lanzi, C., Zaffaroni, N., Colombo, D., & Perego, P. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990106 · Cited by 103 · see citing works

Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases

Rodgers, S. J., Ferguson, D. T., Mitchell, C. A., & Ooms, L. M. (2017) · Bioscience Reports · doi:10.1042/bsr20160432 · Cited by 104 · see citing works

Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy

Higgins, J., Vaughan, O. R., de Liger, E. F., Fowden, A. L., & Sferruzzi-Perri, A. N. (2015) · The Journal of Physiology · doi:10.1113/jp271057 · Cited by 102 · see citing works

SGK1

Cristofano, A. D. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.11.006 · Cited by 101 · see citing works

The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification

Ulici, V., Hoenselaar, K. D., Agoston, H., McErlain, D. D., Umoh, J. U., Chakrabarti, S., Holdsworth, D. W., & Beier, F. (2009) · Bone · doi:10.1016/j.bone.2009.08.003 · Cited by 101 · see citing works

Nonredundant Role of Akt2 for Neuroprotection of Rod Photoreceptor Cells from Light-Induced Cell Death

Li, G., Anderson, R. E., Tomita, H., Adler, R., Liu, X., Zack, D. J., & Rajala, R. V. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0445-06.2007 · Cited by 100 · see citing works

Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations

Rao, G., Pierobon, M., Kim, I., Hsu, W., Deng, J., Moon, Y., Petricoin, E. F., Zhang, Y., Wang, Y., & Giaccone, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-06128-9 · Cited by 98 · see citing works

IGF signaling defects as causes of growth failure and IUGR

Klammt, J., Pfäffle, R. W., Werner, H., & Kieß, W. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.03.003 · Cited by 96 · see citing works

Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia

He, Z., Opland, D. M., Way, K. J., Ueki, K., Bodyak, N., Kang, P. M., Izumo, S., Kulkarni, R. N., Wang, B., Liao, R., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000209500.15801.4e · Cited by 94 · see citing works

In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice

Krey, G., Frank, P., Shaikly, V., Barrientos, G., Russo, R. I. C., Ringel, F., Moschansky, P., Chernukhin, I. V., Metodiev, M. V., Fernández, N., et al. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0379-2 · Cited by 95 · see citing works

PKBα is required for adipose differentiation of mouse embryonic fibroblasts

Baudry, A., Yang, Z., & Hemmings, B. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02792 · Cited by 94 · see citing works

Plant-derived flavanol (−)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice

Stringer, T. P., Guerrieri, D., Vivar, C., & van Praag, H. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.135 · Cited by 94 · see citing works

Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction

Yung, H. W., Hemberger, M., Watson, E. D., Senner, C. E., Jones, C. J. P., Kaufman, R. J., Jones, D. S., & Burton, G. J. (2012) · The Journal of Pathology · doi:10.1002/path.4068 · Cited by 91 · see citing works

Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation

Sun, X., Xie, H., Yang, J., Wang, H., Bradshaw, H. B., & Dey, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010892107 · Cited by 91 · see citing works

BRF1 Protein Turnover and mRNA Decay Activity Are Regulated by Protein Kinase B at the Same Phosphorylation Sites

Benjamin, D., Schmidlin, M., Lu, M., Gross, B., & Moroni, C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01099-06 · Cited by 91 · see citing works

PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms

Briest, F., & Grabowski, P. (2014) · Theranostics · doi:10.7150/thno.7851 · Cited by 89 · see citing works

The murine allantois: emerging paradigms in development of the mammalian umbilical cord and its relation to the fetus

Inman, K. E., & Downs, K. M. (2007) · genesis · doi:10.1002/dvg.20281 · Cited by 88 · see citing works

Activation of elastin transcription by transforming growth factor-β in human lung fibroblasts

Kuang, P., Zhang, X., Rich, C. B., Foster, J. A., Subramanian, M., & Goldstein, R. H. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00184.2006 · Cited by 82 · see citing works

Discovery of a novel class of AKT pleckstrin homology domain inhibitors

Mahadevan, D., Powis, G., Mash, E. A., George, B. L., Gokhale, V. M., Zhang, S., Shakalya, K., Du‐Cuny, L., Berggren, M. I., Ali, M. A., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2276 · Cited by 81 · see citing works

Promiscuous affairs of PKB/AKT isoforms in metabolism

Schultze, S. M., Jensen, J., Hemmings, B. A., Tschopp, O., & Nießen, M. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2010.539236 · Cited by 80 · see citing works

Survival and Size Are Differentially Regulated by Placental and Fetal PKBalpha/AKT1 in Mice1

Plaks, V., Berkovitz, E., Vandoorne, K., Berkutzki, T., Damari, G. M., Haffner, R., Dekel, N., Hemmings, B. A., Neeman, M., & Harmelin, A. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.085951 · Cited by 22 · see citing works

Survival and size are differentially regulated by placental and fetal PKBalpha/ AKT1 in mice. Biol. Reprod

Plaks, V., Berkovitz, E., Katrien, V., Berkutzki, T., Damari, G. M., Haffner, R., Dekel, N., Hemmings, B. A., Neeman, M., & Harmelin, A. (2010)

Survival and Size Are Differentially Regulated by Placental and Fetal PKBalpha/AKT1

Mice, I. (2016)

75 AKT1 deficiency is linked to placental, fetal, and postnatal growth restriction

Winchester, M., Kozai, K., Iqbal, K., Muto, M., Scott, R. L., & Soares, M. J. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.12.075

Vascular function and growth is differentially regulated by fetal and placental PKBalpha/Akt1 in a gene dosage dependent manner: Non-invasive dynamic contrast enhanced MRI

Plaks, V., Berkovitz, E., Vandoorne, K., Sharir, A., Zelzer, E., Wehrli, F. W., Dekel, N., Hemmings, B. A., Neeman, M., & Harmelin, A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.423