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Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-d-aspartate receptors
Abstract
By using extracellular recordings of field potential, the exact pathway by which the endogenous ACh influencing the induction of long-term potentiation (LTP) in CA1 area was analysed in slices of rat hippocampus. The results showed that: (1) the application of (-) huperzine A, an AChE inhibitor extracted from Chinese herb Qian Ceng Ta (Huperzia Serrata), could enhance the induction of LTP, while this drug showed little effect on the second components of multiple population spikes that were recorded in Mg(2+)-free medium and had proven to be N-methyl-D-aspartate (NMDA) receptor-mediated response; and (2) scopolamine, a muscarinic receptor antagonist, could significantly suppressed the induction of LTP, while most of the suppressive effect of scopolamine was blocked when slices were pretreated by bicuculline, a gamma-aminobutyric acid (GABA(A)) receptor antagonist. These results suggest that endogenous ACh potentiates the induction of LTP through the inhibition of GABAergic interneurons that modulate pyramidal neurons, but not through the activation of NMDA receptors located on pyramidal neurons.
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“The initial component (1A) would involve the rapid activation of the hippocampus by the amygdala, in conjunction with local increases in levels of neuromodulators, such as corticotrophin-releasing hormone (CRH) (Adamec et al. [225]; Wang et al. [226]; Wang et al. [227]; Blank et al. [228]; Chen et al. [229]), acetylcholine (Ye et al. [247]; Ovsepian et al. [248]), dopamine (Li et al. [204]; Lisman”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Ye et al. [247]
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Cites
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Sorted by citations
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762
“…hormone (CRH) (Adamec et al. [225]; Wang et al. [226]; Wang et al. [227]; Blank et al. [228]; Chen et al. [229]), acetylcholine (Ye et al. [247]; Ovsepian et al. [248]), dopamine (Li et al. [204]; Lisman and Grace [224]; Ahmed et al. [209]; Lemon and Manahan-Vaughan [249]), and…”
Background
Metadata
- Authors
- Ye, L., Qi, J.-S., & Qiao, J.-T.
- Affiliations
- Shanxi Medical University (CN)
- Corresponding author
- Qiao, Jian-Tian
- ORCID
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 300
- Issue
- 3
- Pages
- 145-148
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1983987784
- Cited by
- 29
- References
- 1
- Citations by year
- 2023: 1 · 2019: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- long-term potentiation, hippocampus, acetylcholine, NMDA receptor, CA1, huperzine A, scopolamine, muscarinic receptors, GABAergic interneurons, pyramidal neurons, GABAA receptor, bicuculline, field potentials, synaptic plasticity
- MeSH terms
- Acetylcholine, Alkaloids, Animals, Bicuculline, Cholinesterase Inhibitors, Electric Stimulation, Hippocampus, Scopolamine, Sesquiterpenes, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Pyramidal Cells, Muscarinic Antagonists, GABA Antagonists, Rats
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