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Cited by 51

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Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

Tanahashi, Hiroshi, Tabira, Takeshi·2001·Neuroscience Letters
DOI 10.1016/s0304-3940(01)01912-7
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Abstract

Three novel alternatively spliced transcripts of the beta-site amyloid precursor protein cleaving enzyme (BACE) were cloned from human brain. Alternative splicing of the RNA occurs at an internal donor in exon 3 and/or an internal acceptor in exon 4. The splicing events lead to a deletion of 25 (BACE-I-476), 44 (BACE-I-457) and 69 (BACE-I-432) amino acids and the latter two caused the loss of two of four N-linked glycosylation sites. Although the mature form of BACE-501 was resistant to endoglycosidase H treatment, glycosylated forms of BACE-I-457 and BACE-I-476 were sensitive. This result suggests that BACE-I-457 and BACE-I-476 underwent different post-translational modifications. Moreover, the beta-secretase activity of BACE-I-457 and BACE-I-476 was significantly weaker than that of BACE-501. Thus, these isoforms may contribute to a physiological function of BACE.

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  • There are six relatively established BACE1 isoforms (A-F), in addition to reports of various less well-characterized forms including BACE1-455 and BACE1-127.

    “There are six relatively established BACE1 isoforms (A–F), in addition to reports of various less well‐characterized forms including BACE1‐455 and BACE1‐127”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [66]

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Research works printed but not linked: 12

  1. Altschul, 1997, Gapped BLAST and PSI-BLAST: a new generation of protein database search program, Nucl. Acids Res., 25, 3389, 10.1093/nar/25.17.3389 · DOI · Paper page
  2. Asami-Odaka, 1995, Long amyloid beta-protein secreted from wild-type human neuroblastoma IMR-32 cells, Biochemistry, 34, 10272, 10.1021/bi00032a022 · DOI
  3. Capell, 2000, Maturation and pro-peptide cleavage of beta-secretase, J. Biol. Chem., 275, 30849, 10.1074/jbc.M003202200 · DOI · Paper page
  4. Farzan, 2000, BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein, Proc. Natl. Acad. Sci. USA, 97, 9712, 10.1073/pnas.160115697 · DOI · Paper page
  5. Haniu, 2000, Characterization of Alzheimer's beta-secretase protein BACE. A pepsin family member with unusual properties, J. Biol. Chem., 275, 21099, 10.1074/jbc.M002095200 · DOI
  6. Huse, 2000, Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase, J. Biol. Chem., 275, 33729, 10.1074/jbc.M004175200 · DOI · Paper page
  7. Hussain, 1999, Identification of a novel aspartic protease (Asp 2) as beta-secretase, Mol. Cell Neurosci., 14, 419, 10.1006/mcne.1999.0811 · DOI · Paper page
  8. Sauder, 2000, Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase, J. Mol. Biol., 300, 241, 10.1006/jmbi.2000.3860 · DOI
  9. Sinha, 1999, Purification and cloning of amyloid precursor protein beta-secretase from human brain, Nature, 402, 537, 10.1038/990114 · DOI · Paper page
  10. Suzuki, 1994, An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants, Science, 264, 1336, 10.1126/science.8191290 · DOI · Paper page
  11. Vassar, 1999, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science, 286, 735, 10.1126/science.286.5440.735 · DOI · Paper page
  12. Yan, 1999, Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity, Nature, 402, 533, 10.1038/990107 · DOI · Paper page

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Metadata

Authors
Tanahashi, H., & Tabira, T.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2001-07
Volume
307
Issue
1
Pages
9-12
ISSN
0304-3940
DOI
10.1016/s0304-3940(01)01912-7
Cited by
51
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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