Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
Abstract
The effects of acute physiological stressors (5 s tail pinch, handling and forced swimming at +25 and +5 degrees C for 3 min each) on serotonin (5-HT) release in the mouse brain were investigated using in vivo microdialysis. The extracellular 5-HT levels were determined by a newly developed highly-sensitive and selective high-performance liquid chromatography method based on derivatization with benzylamine and fluorescence detection. The basal levels of 5-HT in 3 min microdialysates from the ventral hippocampus and frontal cortex were 0.68+/-0.21 and 0.75+/-0.28 fmol/6 microl (n=24), respectively. All three stressors caused an immediate, significant and reversible increase (handling: 150%; swimming: 240%) of extracellular 5-HT levels in both brain structures, suggesting a more dynamic role played by the serotonergic system in response to acute stress.
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P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.
“Based on these findings, P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [92]
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P2X7 Receptor Signaling in Stress and Depression
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- Authors
- Fujino, K., Yoshitake, T., Inoue, O., Ibii, N., Kehr, J., Ishida, J., Nohta, H., & Yamaguchi, M.
- Affiliations
- Chemicals Evaluation and Research Institute (JP)
- Karolinska Institutet (SE)
- The University of Osaka (JP)
- Shionogi (Japan) (JP)
- Fukuoka University (JP)
- Corresponding author
- Yamaguchi, Masatoshi
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 320
- Issue
- 1-2
- Pages
- 91-95
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2021758908
- Cited by
- 86
- References
- 19
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2014: 6 · 2013: 2 · 2012: 4
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin release, acute stress, tail pinch, handling stress, forced swim test, ventral hippocampus, frontal cortex, serotonergic system, extracellular serotonin, microdialysis, fluorescence detection
- MeSH terms
- Acute Disease, Animals, Extracellular Space, Frontal Lobe, Hippocampus, Male, Synaptic Transmission, Neurons, Pain, Physical Stimulation, Restraint, Physical, Serotonin, Stress, Physiological, Swimming, Microdialysis, Mice
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